Manmeet Kaur Gill

Isolated ovarian tuberculosis: Case report and literature review

Although genitourinary tuberculosis (TB) is common, reports of isolated ovarian TB are rare. However, its presentation can mimic that of an ovarian tumor, leading to diagnostic difficulties. A 25-year-old woman presented with chronic pelvic pain, weight loss, a right ovarian mass on ultrasound, and a significantly elevated cancer antigen 125 (CA-125) level. Laparotomy was performed with resection of the right ovary. Postoperative histological examination, however, revealed evidence of TB, with no signs of malignancy. Anti-TB treatment was commenced, with full resolution of her symptoms and a decrease in CA-125 level. Isolated ovarian TB is most common in young women living in endemic zones. CA-125 can be raised in many conditions, and imaging is rarely conclusive. Intraoperative frozen section of tissue specimens can be helpful if available. Early diagnosis of ovarian TB is vital as untreated disease can lead to infertility.

Tuberculous Pericarditis on autopsy: A case report -

Tuberculous (TB) pericarditis, caused by Mycobacterium tuberculosis, is found in approximately 1% of all autopsied cases of TB and in 1-2% of pulmonary TB [1]. Although there has been a significant decline in TB in developed countries over last decades, Asia, Africa and Latin America, with 86% of the World’s population are home to 95% of all cases of active TB and 98% of the nearly 2 million deaths resulting from TB each year [2]. Pericardial involvement by TB was initially described by Rokitansky in 1852, and it was he who noted the “association with, and dependence upon,” an earlier TB lesion [3]. TB pericarditis has a variable clinical presentation and should be considered in the evaluation of all cases of pericarditis without a rapidly self-limited course [4]. TB pericarditis by no means always progresses to the constrictive fibrous stage [3]. In some parts of the world, a TB cause of constrictive pericarditis is more common than a non TB cause [5]. Recent reviews on the diagnosis and management of pericardial disease have paid scant attention to TB pericarditis, which is arguably the leading cause of pericarditis in the world [6,7]. TB pericarditis in an 82-year-old female diagnosed on autopsy is presented herewith.

Malignant Brenner tumor of ovary: A rare entity

Worldwide, ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies. It usually occurs in older women and the average age at presentation is 50 years. Brenner tumor of the ovary is very rare, mostly benign, small, and unilateral. Malignant Brenner tumor is much rarer. These tumors are believed to arise from urothelial metaplasia of ovarian surface epithelium. Malignant Brenner tumor of ovary closely resembles the transitional cell carcinoma of ovary. They must be differentiated because the latter has a worse prognosis. A case of unilateral malignant Brenner tumor in a postmenopausal woman is reported here and its features are briefly discussed.