Marcin Augustyniak

CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement

This paper presents a fully electronic label-free DNA chip in 0.5-mum CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated

A 24x16 CMOS-Based Chronocoulometric DNA Microarray

An array of 24 times 16 electrochemical sensors for detecting bio-molecules uses gold sensor electrodes added to a 0.5 mum CMOS process. Detection is based on time-resolved measurement of charge (chronocoulometry). A differential measurement technique uses a replica electrode and fast integration to suppress background offset signals

Fully Electronic CMOS DNA Detection Array Based on Capacitance Measurement with On-Chip Analog-to-Digital Conversion

An 8 times 16 array of sensing micro-sites employs a fully-electrical label-free technique for DNA recognition using capacitance measurement and is fabricated in 0.5mum CMOS with added noble metal. Repeatability and parallel detection capability have been demonstrated. The DNA-chip is suitable for low-cost, fully-integrated point-of-care applications