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Dive into the research topics where Maria Cristina Parolin is active.

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Featured researches published by Maria Cristina Parolin.


Experimental Biology and Medicine | 2012

SERPINB3 expression on B-cell surface in autoimmune diseases and hepatitis C virus-related chronic liver infection:

Laura Vidalino; Andrea Doria; S. Quarta; Marika Crescenzi; Mariagrazia Ruvoletto; Federica Frezzato; Livio Trentin; C. Turato; Maria Cristina Parolin; Anna Ghirardello; Luca Iaccarino; Luisa Cavalletto; Liliana Chemello; Angelo Gatta; Patrizia Pontisso

SERPINB3 is a serine protease inhibitor with pleiotropic functions. It is involved in several physiological and pathological processes, where it appears to exert antiapoptotic effects. Little is known about its expression on immune system cells, the major players in mechanisms of viral defense and autoimmune disorders. The aim of this study was to characterize the expression of SERPINB3 on the surface of peripheral blood mononuclear cell subsets in both normal subjects and in patients with chronic viral infections and autoimmune diseases. Sixty-two patients were analyzed by flow cytometric analysis, including 45 with hepatitis C virus (HCV)-related chronic liver disease and 17 with systemic lupus erythematosus (SLE). SERPINB3 was expressed on B lymphocytes in 79% of the controls, in 32% of the HCV-infected patients and in none of the SLE patients. Surface localization of SERPINB3 was confirmed by confocal microscopy. SERPINB3 positivity was associated with CD27 reactivity (r = 0.98), but not to other activation molecules (CD69, CD71, CD86 and CXCR3). SERPINB3 is physiologically expressed on the surface of CD27+ B lymphocytes, but its expression is reduced in HCV viral infection and not detectable in SLE patients. These results may suggest a role for SERPINB3 in B-cell defects typically found in viral infections and autoimmune disorders.


Antiviral Research | 1993

Relevance of DNA binding to the mechanism of anti-herpesvirus activity of benzhydrazone.

Giorgio Palù; Mauro Tognon; Maria Grazia Romanelli; Mario Rassu; Maria Cristina Parolin; Giuseppe Zagotto; Manlio Palumbo

Benzhydrazone (1H-benz(f)indene-1,3(2H)-dione bis (amidino-hydrazone) (BH) is a synthetic compound with selective anti-herpesvirus activity. Its selectivity seems to stem from the inhibition of viral protein glycosylation and several hypotheses have been formulated to explain such an effect. Data presented here demonstrate that DNA binding is a prominent feature of BH. Interaction is taking place with a relatively high affinity constant and is more efficient for GC-rich viral sequences. Experiments with the cloned DNA fragments from a BH-resistant virus strain indicate that BH-DNA complex formation is drastically reduced as compared to BH-sensitive virus. The occurrence of the resistant phenotype in HEp-2 cells but not in Vero cells could be explained by differences in BH cytotoxicity. Changes in drug uptake and accumulation by cells following infection, in addition to GC preference, may also account for the degree of antiviral selectivity shown by BH.


European Journal of Clinical Microbiology & Infectious Diseases | 1991

Further insight into the mechanism of action of quinolones

Giorgio Palù; Sebastiano Valisena; Maria Cristina Parolin; Giovanni Ciarrocchi; Manlio Palumbo


Neuro-oncology | 2017

P08.69 A lentiviral-based system for targeting the regulatory subunit R2A of protein kinase A in human glioblastoma

Maira Zorzan; Claudia Del Vecchio; Arianna Calistri; Maria Cristina Parolin; Carla Mucignat


13th National Congress of the Italian Society for Virology | 2015

Dissecting the molecular mechanisms accounting for the Feline Immunodeficiency Virus Envelope Glycoprotein ability to antagonize feline tetherin restriction

Michele Celestino; Arianna Calistri; Mario Vincenzo Di Iorio; Giorgio Palù; Maria Cristina Parolin


Virologie | 2013

Lentiviral delivery of multiple short hairpin RNAS: A gene therapyapproach for HIV 1 infection

Francesca Spanevello; Arianna Calistri; Claudia Del Vecchio; Barbara Mantelli; Sg Parisi; Giorgio Palù; M Cavazzana Calvo; Maria Cristina Parolin


Archive | 2013

Gene Therapy approaches for corneal diseases

Mario Vincenzo Di Iorio; Barbaro Vanessa; Claudia Del Vecchio; Parekh Mohit; Gualtiero Alvisi; Valentina Poletti; Giorgio Palù; Maria Cristina Parolin


10th National Congress of the Italian Society of Virology | 2011

Inhibition of feline immunodeficiency virus release by feline tetherin

Michele Celestino; Arianna Calistri; Claudia Del Vecchio; Mauro Pistello; Giorgio Palù; Maria Cristina Parolin


10th National Congress of the Italian Society for Virology | 2011

Production of influenza virus like particles by expression of engineered M1 proteins.

Marta Toffoletto; Arianna Calistri; Cristiano Salata; Maria Cristina Parolin; Giorgio Palù


9th National Congress of the Italian Society of Virology | 2009

Role of tegument proteins in herpes simplex virus type 1 and multivesicular bodies interactions

Alessandra Comin; Paola Sette; Carlo Barbera; G Campadelli Fiume; Giorgio Palù; Arianna Calistri; Maria Cristina Parolin

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Paola Sette

National Institutes of Health

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