Mária Weber
Szent István University
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Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment | 2008
Judit Fodor; Krisztián Balogh; Mária Weber; Miklós Mézes; László Kametler; Roland Pósa; Rene Mamet; Johann Bauer; Péter Horn; Ferenc Kovács; Melinda Kovács
The absorption, distribution and elimination of fumonisin B1 (and B2) after oral administration of Fusarium verticillioides (MRC 826) fungal culture, mixed into the experimental feed for 10 days, was studied in weaned barrows. In order to determine the absorption of FB1 from the feed marked by chromium oxide, a special T-cannula was implanted into the distal part of pigs’ ileum. During the feeding of toxin-containing diet (45 mg FB1 kg−1) and until the tenth day after the end of treatment, the total quantity of urine and faeces was collected and their toxin content analysed. At the end of the trial, samples of lung, liver, kidney, brain, muscle, and fat were also collected and their fumonisin content analysed by LC-MS. The fumonisins appeared to decrease the reduced glutathione content in blood plasma and red blood cell haemolysate, possibly associated with in vivo lipid peroxidation. From a data set of 80 individual data and the concentration and rate of C r and fumonisins (FB1, partially hydrolysed FB1 and aminopentol) in the chymus, it could be established that the accumulative absorption of fumonisin B1 was 3.9% ± 0.7%. In the chymus, the FB1 conversions into aminopentol and partially hydrolysed FB1 were 1.0 and 3.9%, respectively. The degree of metabolism in faeces was variable, although the main product was the partially hydrolysed form, with very small amounts of the aminopentol moiety being recovered. In the investigated tissues the FB1 conversion to aminopentol and partially hydrolysed FB1 was 30 and 20%, respectively.
Acta Veterinaria Hungarica | 2009
László Pál; Károly Dublecz; Mária Weber; Krisztián Balogh; Márta Erdélyi; Gábor Szigeti; Miklós Mézes
Three groups of cockerels were fed with a control diet, with a diet contaminated with T-2 and HT-2 toxin (0.31 and 0.26 mg/kg) or with that containing a combination of T-2 and HT-2 toxin (0.32 and 0.25 mg/kg) and aflatoxin B1 (AFB1, 0.38 mg/kg) for 21 days. Body weight gain and feed conversion ratio did not differ significantly among the groups. Malondialdehyde concentration of the liver was lower in the group fed the diet contaminated with the combination of T-2 + HT-2 toxin and aflatoxin B1 as compared to the control group or the group fed T-2 + HT-2 toxins. Reduced glutathione (GSH) content of the liver was lower in the T-2 + HT-2 group than in the group fed a combination of T-2, HT-2 and aflatoxin. Reduced glutathione content of the heart was higher in the T-2 + HT-2 group than in the control group. Mycotoxin contamination had no effect on glutathione peroxidase (GSH-Px) activity in comparison to the control, but significantly lower GSH-Px activity was found in the heart of chickens in the T-2 + HT-2 + AFB1 group than in the T-2 + HT-2 group. In this study, T-2 + HT-2 toxin and aflatoxin B1 contamination of the diets did not affect the production traits adversely and did not exert additive effects on lipid peroxidation and on the glutathione redox system.
Acta Veterinaria Hungarica | 2007
Krisztián Balogh; J. Hausenblasz; Mária Weber; Márta Erdélyi; Judit Fodor; Miklós Mézes
The effect of feeding ochratoxin A (OTA) contaminated diet (379.6 and 338.1 microg/kg in starter and grower diets) on production traits, lipid peroxidation and some parameters of the glutathione redox system were investigated in weaned piglets over a seven-week period. Feed intake and feed conversion ratio (FCR) did not differ significantly, but in the first phase (0-28 days) the daily weight gain was significantly lower in the piglets fed the OTA-contaminated diet. Lipid peroxidation, as measured by the amount of malondialdehyde, glutathione content and glutathione peroxidase activity, did not change significantly in the blood plasma and red blood cell haemolysate in the OTA-loaded group, while malondialdehyde content increased significantly in the liver and markedly but not significantly in the kidney of piglets fed OTA-contaminated feed. Glutathione content did not differ significantly in the studied organs of the two groups while glutathione peroxidase activity of the OTA-loaded animals was significantly lower both in the liver and in the kidney. The results suggest that the use of feed-stuffs contaminated with low levels of OTA for seven weeks did not cause marked differences in the production traits or in lipid peroxidation and amount or activity of the glutathione redox system in the blood plasma, red blood cells and kidney, while significant changes occurred in the liver homogenate.
Acta Veterinaria Hungarica | 2004
Krisztián Balogh; Mária Weber; Márta Erdélyi; Miklós Mézes
Acta Veterinaria Brno | 2010
Mária Weber; Krisztián Balogh; Judit Fodor; Márta Erdélyi; Zsolt Ancsin; Miklós Mézes
Acta Veterinaria Hungarica | 2007
Mária Weber; Sz Stiller; Krisztián Balogh; László Wágner; Márta Erdélyi; Miklós Mézes
Acta Biologica Hungarica | 2007
Krisztián Balogh; Mária Weber; Márta Erdélyi; Miklós Mézes
Journal of Poultry Science | 2006
Mária Weber; Krisztián Balogh; Márta Erdélyi; Miklós Mézes
Acta Biologica Szegediensis | 2003
Miklós Mézes; Márta Erdélyi; Gihan Shaaban; Györgyi Virág; Krisztián Balogh; Mária Weber
Fleischwirtschaft | 2006
Csaba Ábraham; Klaus Ender; Krisztián Balogh; Mária Weber; Julianna Seenger; Miklós Mézes; Hedvig Fébel; Endre Szücs