Marianne Z. Wamboldt
University of Colorado Boulder
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Journal of Child Psychology and Psychiatry | 2010
Barbara H. Fiese; Marcia A. Winter; Frederick S. Wamboldt; Rani D. Anbar; Marianne Z. Wamboldt
BACKGROUND Respiratory problems have been shown to be associated with the development of panic anxiety. Family members play an essential role for children to emotionally manage their symptoms. This study aimed to examine the relation between severity of respiratory symptoms in children with asthma and separation anxiety. Relying on direct observation of family interactions during a mealtime, a model is tested whereby family interactions mediate the relation between asthma severity and separation anxiety symptoms. METHODS Sixty-three children (ages 9-12 years) with persistent asthma were interviewed via the Diagnostic Interview Schedule for Children IV; family interactions were assessed via direct observation of a mealtime; primary caregivers completed the Childhood Asthma Severity Scale; youth pulmonary function was ascertained with pre- and post-bronchodilator spirometry; adherence to asthma medications was objectively tracked for six weeks. RESULTS Poorer pulmonary function and higher functional asthma severity were related to higher numbers of separation anxiety symptoms. Controlling for medication adherence, family interaction patterns mediated the relationship between poorer pulmonary function and child separation anxiety symptoms. CONCLUSIONS Family mealtime interactions may be a mechanism by which respiratory disorders are associated with separation anxiety symptoms in children, potentially through increasing the childs capacity to cognitively frame asthma symptoms as less threatening, or through increasing the childs sense of security within their family relationships.
Journal of Child and Adolescent Psychopharmacology | 2015
Robert L. Findling; Ronald P. Landbloom; Mary Mackle; Wendi Pallozzi; Sabine Braat; Carla Hundt; Marianne Z. Wamboldt; Maju Mathews
OBJECTIVE The purpose of this study was to evaluate the safety and efficacy of asenapine in adolescents with schizophrenia. METHODS In an 8 week, randomized, double-blind placebo-controlled trial, subjects (12-17 years of age) meeting Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR) criteria for schizophrenia were randomized 1:1:1 to placebo, asenapine 2.5 mg b.i.d., or asenapine 5 mg b.i.d. Subjects who completed the 8 week acute study could participate in a 26 week flexible-dose asenapine-only open-label extension (OLE). RESULTS A similar percentage of subjects completed treatment on day 56 (2.5 mg b.i.d. (n=98): 83%; 5 mg b.i.d. [n=106]: 79%; placebo [n=102]: 79%). In the mixed model for repeated measures analysis of the primary end-point (with Hochberg correction for multiplicity), least squares (LS) mean differences between asenapine and placebo on the Positive and Negative Syndrome Scale (PANSS) total score at day 56 were not significant (-4.8 for 2.5 mg b.i.d., p=0.070; -5.6 for 5 mg b.i.d., p=0.064). Significant improvement in the Clinical Global Impressions-Severity score was observed in the 5 mg b.i.d. group versus placebo on day 56 (LS mean -0.3, p=0.024). In the acute phase, ≥7% weight gain and the composite event of somnolence, sedation, and hypersomnia were more common in both asenapine groups than in the placebo group. Akathisia, fasting glucose elevation, and extrapyramidal syndrome were more common in the 5 mg b.i.d. group than in the placebo group. There were no unexpected adverse events in the OLE, and PANSS total scores decreased by -16.1 points in the group previously treated with placebo (n=62) and by -11.2 points in the continuous asenapine group (n=131) from OLE baseline to week 26. CONCLUSIONS Although improvements in PANSS total score at day 56 of the acute phase were numerically greater for both asenapine 2.5 and 5 mg b.i.d. than for placebo and were maintained in the OLE, the primary end-point did not achieve statistical significance in the acute phase. No new or unexpected safety concerns were detected during the acute phase or after an additional 26 weeks of asenapine treatment in the adolescent population with schizophrenia. CLINICAL TRIALS REGISTRY NCT01190254 and NCT1190267 at ClinicalTrials.gov.
Academic Psychiatry | 2008
Ellen M. Berman; Alison M. Heru; Henry Grunebaum; John S. Rolland; John Sargent; Marianne Z. Wamboldt; Susan H. McDaniel
ObjectiveBecause family oriented patient care improves patient outcome and reduces family burden, clinical family skills of communication assessment alliance and support are part of core competencies required of all residents. Teaching residents to “think family” as part of core competencies and to reach out to families requires change in the teaching environment.MethodsThis article advocates teaching residents family skills throughout the training years as an integrated part of routine patient care rather than in isolated family clinics or a course in “family therapy.” It reviews family skills required of residents in all treatment settings and family skills that are specific to inpatient, emergency room, outpatient, and consultation-liaison services.ResultsFamilies can be seen in multiple treatment settings throughout resident training using recent research to support appropriate interventions for patients and caregivers.ConclusionThe process of establishing change in the training environment requires a commitment on the part of the training faculty to include families, but is possible within the current training framework.
Journal of Pediatric Psychology | 1996
Gregory K. Fritz; Albert Yeung; Marianne Z. Wamboldt; Anthony Spirito; Elizabeth L. McQuaid; Robert B. Klein; Ronald Seifer
Archive | 2001
Marianne Z. Wamboldt; Frederick S. Wamboldt
Lung biology in health and disease | 1998
Gregory K. Fritz; Marianne Z. Wamboldt
Journal of the American Academy of Child and Adolescent Psychiatry | 2016
William Bernet; Marianne Z. Wamboldt; William E. Narrow
Pediatric Respiratory Medicine (Second Edition) | 2008
Frederick S. Wamboldt; Marianne Z. Wamboldt
Archive | 2010
Marianne Z. Wamboldt; Srh Beach; Nadine J. Kaslow; Richard E. Heyman; Mb First; David Reiss
The Oxford Handbook of Relationship Science and Couple Interventions | 2016
Heather M. Foran; Richard E. Heyman; Amy M. Smith Slep; Steven R. H. Beach; Nadine J. Kaslow; Anthony R. Cordaro; Marianne Z. Wamboldt; David Reiss