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Dive into the research topics where Marineh Yagubyan is active.

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Featured researches published by Marineh Yagubyan.


Vascular and Endovascular Surgery | 2004

Axillary artery injury from humeral neck fracture: a rare but disabling traumatic event.

Marineh Yagubyan; Jean M. Panneton

Axillary artery injury from blunt trauma to the shoulder is uncommon. Fracture of the neck of the humerus is a rare cause of injury to the axillary artery. Four cases of axillary artery thrombosis from humeral neck fracture are reported. Each of the first 2 patients presented with a pulseless and acutely ischemic limb after a trivial fall. A repair of the axillary artery with saphenous vein interposition graft was performed in the first patient. The extremity was salvaged, but a residual radial and ulnar neurologic deficit persisted. The second patient presented with a pulseless insensate upper extremity accompanied by motor loss. He underwent primary axillary artery repair. Still early in his postoperative course, he has had global brachial plexopathy and is undergoing intensive physical therapy. The third patient had a delayed presentation of brachial plexopathy and sympathetic reflex dystrophy. Arterial reconstruction was not required owing to excellent collateralization. The fourth patient presented with a cool pulseless extremity. His recovery is nearly complete after bypass of the axillary artery with a reversed saphenous vein graft. In addition, a review of the literature revealed 24 cases of axillary artery injury associated with humeral neck fracture. The mean age was 66.6 years. The most common mechanism of injury was a fall (79%). Thirteen patients (46%) presented with a neurologic deficit. Acute ischemia was present in 68%. Physical examination predicted the arterial injury in all but 1 patient. The injured axillary artery was repaired in 26 cases. Revascularization by an interposition graft was the most common procedure. All grafts and reanastomoses were patent and led to limb salvage. Of 9 primary repairs, 3 amputations were performed. Although limb salvage rate was 89%, a good functional outcome was obtained in only half of the patients. A high index of suspicion is required for early diagnosis of axillary artery injury. Despite excellent results of vascular reconstruction, the outcome remains determined by the excessive neurologic morbidity. Recognition of the associated brachial plexus injury is essential to improve the functional outcome of this unusual arterial injury.


The Journal of Thoracic and Cardiovascular Surgery | 2007

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms.

Stephen H. McKellar; David J. Tester; Marineh Yagubyan; Ramanath Majumdar; Michael J. Ackerman; Thoralf M. Sundt


American Journal of Physiology-heart and Circulatory Physiology | 2004

Evidence of nanobacterial-like structures in calcified human arteries and cardiac valves

Virginia M. Miller; George P. Rodgers; Jon A. Charlesworth; Brenda L. Kirkland; Sandra R. Severson; Todd E. Rasmussen; Marineh Yagubyan; Jeri C. Rodgers; Franklin R. Cockerill; Robert L. Folk; Ewa Rzewuska-Lech; Vivek Kumar; Gerard Farell-Baril; John C. Lieske


The Journal of Thoracic and Cardiovascular Surgery | 2005

Aortic root replacement with a novel decellularized cryopreserved aortic homograft: Postoperative immunoreactivity and early results

Kenton J. Zehr; Marineh Yagubyan; Heidi M. Connolly; Susan M. Nelson; Hartzell V. Schaff


Journal of Surgical Research | 2007

Evidence of genetic locus heterogeneity for familial bicuspid aortic valve.

Jay W. Ellison; Marineh Yagubyan; Ramanath Majumdar; Gobinda Sarkar; Mark E. Bolander; Elizabeth J. Atkinson; Maurice E. Sarano; Thoralf M. Sundt


The Journal of Thoracic and Cardiovascular Surgery | 2006

Bicuspid aortic valve and ascending aortic aneurysm are not associated with germline or somatic homeobox NKX2-5 gene polymorphism in 19 patients

Ramanath Majumdar; Marineh Yagubyan; Gobinda Sarkar; Mark E. Bolander; Thoralf M. Sundt


Annals of Vascular Surgery | 2005

Comparison of Precuffed and Vein-Cuffed Expanded Polytetrafluoroethylene Grafts for Infragenicular Arterial Reconstructions:A Case-Matched Study

Gustavo S. Oderich; Jean M. Panneton; Marineh Yagubyan; Thomas C. Bower; Jan Hofer; Audra A. Noel; Timothy M. Sullivan; Manju Kalra; Kenneth J. Cherry; Peter Gloviczki


Journal of Vascular Surgery | 2004

LEOPARD syndrome: a new polyaneurysm association and an update on the molecular genetics of the disease☆

Marineh Yagubyan; Jean M. Panneton; Noralane M. Lindor; Emanuela Conti; Anna Sarkozy; Antonio Pizzuti


Journal of Surgical Research | 2004

C-reactive protein as a marker of severe calcification among patients with bicuspid aortic valve disease

Marineh Yagubyan; Gobinda Sarkar; R.A. Nishimura; Thoralf M. Sundt


Journal of Surgical Research | 2010

Long-Term Risk and Predictors of Aortic Events Following Aortic Valve Replacement in Patients with Bicuspid Aortic Valves

Stephen H. McKellar; Marineh Yagubyan; M. Hector; Hartzell V. Schaff; Thoralf M. Sundt

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Jean M. Panneton

Eastern Virginia Medical School

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