Mayur J. Bhanushali

ZrOCl2·8H2O: An Efficient Catalyst for One-Pot Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions

Abstract A highly efficient protocol has been developed for the three-component reaction of an amine, an aldehyde, and diethyl phopshite catalyzed by ZrOCl2·8H2O, an environmentally friendly catalyst, at ambient temperature. The catalyst exhibited remarkable activity and tolerated a wide variety of functional groups, providing the desired amino phosphonates in excellent yields under solvent-free conditions. Alternatively, the reaction rate can be significantly enhanced by carrying out the reaction in a monomode microwave reactor as a promoter.

Synthesis of Sterically Hindered 1,3‐Diketones

Abstract An efficient and practical method for the synthesis of sterically hindered aliphatic/aromatic 1,3‐diketones via coupling of ketones with esters using potassium tert‐butoxide is described. The protocol requires milder operating conditions, and the products are obained in good to excellent yields.

Ultrasound‐Assisted Synthesis of β‐Enaminonitriles in the Presence of Base

Abstract Application of ultrasound shows significant rate enhancement for the synthesis of β‐enaminonitriles in the presence of base. The role of various homogeneous and heterogeneous bases/solvents was also studied for the reaction, and potassium t‐butoxide/t‐butyl alcohol combination was found to give the best result at room temperature.