Sachin R. Jagtap

Cesium carbonate catalyzed efficient synthesis of quinazoline-2,4(1H,3H)-diones using carbon dioxide and 2-aminobenzonitriles

Abstract An efficient protocol for the synthesis of quinazoline-2,4(1H,3H)-diones derivatives from 2-aminobenzonitriles with carbon dioxide using catalytic amount of cesium carbonate has been developed. 6,7-Dimethoxyquinazoline-2,4(1H,3H)-dione, which is one of the key intermediate for the synthesis of several drugs (Prazosin, Bunazosin and Doxazosin) was synthesized. The effect of different reaction parameters like influences of bases, solvent, temperature, CO2 pressure and reaction time were investigated for the title reaction.

ZrOCl2·8H2O: An Efficient Catalyst for One-Pot Synthesis of α-Amino Phosphonates Under Solvent-Free Conditions

Abstract A highly efficient protocol has been developed for the three-component reaction of an amine, an aldehyde, and diethyl phopshite catalyzed by ZrOCl2·8H2O, an environmentally friendly catalyst, at ambient temperature. The catalyst exhibited remarkable activity and tolerated a wide variety of functional groups, providing the desired amino phosphonates in excellent yields under solvent-free conditions. Alternatively, the reaction rate can be significantly enhanced by carrying out the reaction in a monomode microwave reactor as a promoter.

Synthesis of 1,3-Disubstituted Symmetrical/Unsymmetrical Ureas via Cs2CO3-Catalyzed Transamination of Ethylene Carbonate and Primary Amines

Abstract Cs2CO3-catalyzed transamination of primary amines and ethylene carbonate proceeds to form 1,3-disubstituted symmetrical/unsymmetrical ureas in excellent yields. The effect of different reaction parameters such as influences of bases, temperature, and reaction time were investigated for the title reaction.

Ultrasound‐Assisted Synthesis of β‐Enaminonitriles in the Presence of Base

Abstract Application of ultrasound shows significant rate enhancement for the synthesis of β‐enaminonitriles in the presence of base. The role of various homogeneous and heterogeneous bases/solvents was also studied for the reaction, and potassium t‐butoxide/t‐butyl alcohol combination was found to give the best result at room temperature.

Ultrasound assisted regioselective sulfonation of aromatic compounds with sulfuric acid

A simple and convenient methodology for selective sulfonation of aromatic compounds using sulfuric acid under sonication is described. The present methodology shows a considerable enhancement in the reaction rate along with improved selectivity compared with the reactions performed under silent conditions. The effect of various parameters such as agitation speed, sulfuric acid concentration, and temperature on reaction system have been investigated and are explained on the basis of ultrasonically generated cavitational effects.

Synthesis of propargylic alcohols by base promoted alkynylation of ketones with ethynylbenzene using ionic liquid [(bmim) PF6]

A mild and efficient addition of ethynylbenzene with ketones using KOH in ionic liquid 1-butyl-3-methylimidazolium hexaflurophosphate [(bmim) PF6] gives propargylic alcohols in high yields.