Megha Padi

Warped \(AdS_3\) Black Holes

Three dimensional topologically massive gravity (TMG) with a negative cosmological constant ???2 and positive Newton constant G admits an AdS3 vacuum solution for any value of the graviton mass ?. These are all known to be perturbatively unstable except at the recently explored chiral point ?? = 1. However we show herein that for every value of ?? ? 3 there are two other (potentially stable) vacuum solutions given by SL(2,) ? U(1)-invariant warped AdS3 geometries, with a timelike or spacelike U(1) isometry. Critical behavior occurs at ?? = 3, where the warping transitions from a stretching to a squashing, and there are a pair of warped solutions with a null U(1) isometry. For 3

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

>?? > 3, there are known warped black hole solutions which are asymptotic to warped AdS3. We show that these black holes are discrete quotients of warped AdS3 just as BTZ black holes are discrete quotients of ordinary AdS3. Moreover new solutions of this type, relevant to any theory with warped AdS3 solutions, are exhibited. Finally we note that the black hole thermodynamics is consistent with the hypothesis that, for 3

Warped AdS(3) Black Holes

>?? > 3, the warped AdS3 ground state of TMG is holographically dual to a 2D boundary CFT with central charges and .

Warped AdS3 black holes

Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype–phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts have identified numerous germline mutations, and large numbers of somatic genomic alterations, associated with a predisposition to cancer. However, it remains difficult to distinguish background, or ‘passenger’, cancer mutations from causal, or ‘driver’, mutations in these data sets. Human viruses intrinsically depend on their host cell during the course of infection and can elicit pathological phenotypes similar to those arising from mutations. Here we test the hypothesis that genomic variations and tumour viruses may cause cancer through related mechanisms, by systematically examining host interactome and transcriptome network perturbations caused by DNA tumour virus proteins. The resulting integrated viral perturbation data reflects rewiring of the host cell networks, and highlights pathways, such as Notch signalling and apoptosis, that go awry in cancer. We show that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations. Together, these complementary approaches increase the specificity of cancer gene identification. Combining systems-level studies of pathogen-encoded gene products with genomic approaches will facilitate the prioritization of cancer-causing driver genes to advance the understanding of the genetic basis of human cancer.

Non-supersymmetric attractor flow in symmetric spaces

Three dimensional topologically massive gravity (TMG) with a negative cosmological constant ???2 and positive Newton constant G admits an AdS3 vacuum solution for any value of the graviton mass ?. These are all known to be perturbatively unstable except at the recently explored chiral point ?? = 1. However we show herein that for every value of ?? ? 3 there are two other (potentially stable) vacuum solutions given by SL(2,) ? U(1)-invariant warped AdS3 geometries, with a timelike or spacelike U(1) isometry. Critical behavior occurs at ?? = 3, where the warping transitions from a stretching to a squashing, and there are a pair of warped solutions with a null U(1) isometry. For 3

Viral perturbations of host networks reflect disease etiology.

>?? > 3, there are known warped black hole solutions which are asymptotic to warped AdS3. We show that these black holes are discrete quotients of warped AdS3 just as BTZ black holes are discrete quotients of ordinary AdS3. Moreover new solutions of this type, relevant to any theory with warped AdS3 solutions, are exhibited. Finally we note that the black hole thermodynamics is consistent with the hypothesis that, for 3

Higher-order corrections to mass-charge relation of extremal black holes

>?? > 3, the warped AdS3 ground state of TMG is holographically dual to a 2D boundary CFT with central charges and .

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

Three dimensional topologically massive gravity (TMG) with a negative cosmological constant ???2 and positive Newton constant G admits an AdS3 vacuum solution for any value of the graviton mass ?. These are all known to be perturbatively unstable except at the recently explored chiral point ?? = 1. However we show herein that for every value of ?? ? 3 there are two other (potentially stable) vacuum solutions given by SL(2,) ? U(1)-invariant warped AdS3 geometries, with a timelike or spacelike U(1) isometry. Critical behavior occurs at ?? = 3, where the warping transitions from a stretching to a squashing, and there are a pair of warped solutions with a null U(1) isometry. For 3

Canonical NF-κB Activation Is Essential for Epstein-Barr Virus Latent Membrane Protein 1 TES2/CTAR2 Gene Regulation

>?? > 3, there are known warped black hole solutions which are asymptotic to warped AdS3. We show that these black holes are discrete quotients of warped AdS3 just as BTZ black holes are discrete quotients of ordinary AdS3. Moreover new solutions of this type, relevant to any theory with warped AdS3 solutions, are exhibited. Finally we note that the black hole thermodynamics is consistent with the hypothesis that, for 3

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation

>?? > 3, the warped AdS3 ground state of TMG is holographically dual to a 2D boundary CFT with central charges and .