Mervat Mohammed Abdel-Khalik

ENAMINONES IN ORGANIC SYNTHESIS: A NOVEL SYNTHESIS OF 1,3,5-TRISUBSTITUTED BENZENE DERIVATIVES AND OF 2-SUBSTITUTED-5-AROYLPYRIDINES

ABSTRACT Enaminones undergo self-condensation on reflux in acidic media yielding 1,3,5-trisubstituted benzene in very high yields. Reaction of enaminones 1a,b with ethyl propiolate affords 5-aroyl-1,3-benzene dicarboxylate derivatives.

Enaminones as Building Blocks In Heterocyclic Synthesis: A New One Pot Synthesis of Polyfunctional Substituted Pyridines

Enaminones react with a variety of active methyl and methylene reagents in presence of ammonium acetate to yield functionally substituted pyridines in good yields. The reaction proceeded via initial Michael addition across the double bond followed by cyclization. The reaction of enaminone with aromatic aldehyde in acetic acid/ammonium acetate afforded the dihydropyridine that was oxidized to the corresponding pyridine.