Mona Hassan Mohamed

Reaction of Ethyl 2-Diazo-4,5,6,7-Tetrahydrobenzo[B] Thiophene 3-Carboxylate with Benzoyl Acetonitrile: Synthesis of Pyrazoles, Pyridazines, Pyrimidines and Their Fused Derivatives

Abstract The reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene 3-carboxylate I with benzoylacetonitrile (2) gave compound 3. The reactivity of the latter product towards variety of chemical reagents was studied to give fused thiophene derivatives of high potential pharmaceutical uses.

Nitriles in Heterocyclic Synthesis: Novel Syntheses of Functionally Substituted Isoxazoles, Pyrazoles, Pyrazines and their Condensed Derivatives

Novel syntheses of functionally substituted isoxazoles, pyrazoles and pyrazines have been reported utilizing ethyl tosyloximinoglyoxalate (1) and the pyridinium salt 2 as starting materials. Functionally substituted nitriles are versatile reagents and their utility in heterocyclic synthesis has received considerable recent attention [3 - 7]. In previous work we have reported several new approaches for the synthesis of azoles, azines and azoloazines utilizing simple readily obtainable polyfunctional nitriles as starting materials [8-12]. Although 1 and 2 can be readily prepared from ethyl cyanoacetate, however, their utility in synthesis of heterocycles has received only very little attention [1, 2, 13-16]