Michael Su
Vertex Pharmaceuticals
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Publication
Featured researches published by Michael Su.
Nature Medicine | 2004
Elizabeth A Harrington; David Bebbington; Jeff Moore; Richele Rasmussen; Abi O Ajose-Adeogun; Tomoko Nakayama; Joanne A Graham; Cecile Demur; Thierry Hercend; Anita Diu-Hercend; Michael Su; Julian Golec; Karen Miller
The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression and activity of these kinases occur in a wide range of human tumors, and lead to aneuploidy and tumorigenesis. Here we report the discovery of a highly potent and selective small-molecule inhibitor of Aurora kinases, VX-680, that blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor types. This compound causes profound inhibition of tumor growth in a variety of in vivo xenograft models, leading to regression of leukemia, colon and pancreatic tumors at well-tolerated doses. Our data indicate that Aurora kinase inhibition provides a new approach for the treatment of multiple human malignancies.
Archive | 1996
Mark J. Batchelor; David Bebbington; Guy W. Bemis; Wolf Herman Fridman; Roger John Gillespie; Julian Golec; Yong Gu; David J. Lauffer; David J. Livingston; Saroop Singh Matharu; Michael Mullican; Mark A. Murcko; Robert Murdoch; Philip L. Nyce; Andrea L. C. Robidoux; Michael Su; M. Woods Wannamaker; Keith P. Wilson; Robert E. Zelle
Archive | 1999
Francesco G. Salituro; John P. Duffy; Edmund Harrington; Guy W. Bemis; John Cochran; Mark A. Murcko; Keith P. Wilson; Michael Su; Vincent Galullo
Archive | 1997
Robert E. Zelle; Michael Su
Archive | 1997
Guy W. Bemis; Francesco G. Salituro; John P. Duffy; John Cochran; Edmund Harrington; Mark A. Murcko; Keith P. Wilson; Michael Su; Vincent Galullo
Archive | 1997
Michael Su; Robert E. Zelle
Archive | 1997
Robert E Zelle; Michael Su
Archive | 1997
Robert E Zelle; Michael Su
Archive | 1996
Mark J. Batchelor; David Bebbington; Guy W. Bemis; Wolf Herman Fridman; Roger John Gillespie; Julian Golec; Yong Gu; David J. Laufer; David J. Livingston; Saroop S. Matharu; Michael Mullican; Mark A. Murcko; Robert Murdoch; Philip L. Nyce; Andrea L. C. Robidoux; Michael Su; M. Woods Wannamaker; Keith P. Wilson; Robert E. Zelle
Archive | 1996
Mark J. Batchelor; David Bebbington; Guy W. Bemis; Wolf Herman Fridman; Roger John Gillespie; Julian Golec; Yong Gu; David J. Lauffer; David J. Livingston; Saroop S. Matharu; Michael Mullican; Mark A. Murcko; Robert Murdoch; Philip L. Nyce; Andrea L. C. Robidoux; Michael Su; M. Woods Wannamaker; Keith P. Wilson; Robert E. Zelle