Michel Hubert-Habart

A new “one flask” preparation of 2-alkylamino-4-chloroquinazolines from ortho aminobenzonitriles and phosgeniminium salts

Abstract Phosgeniminium salts 7 react easily with ortho amino-benzonitriles 6 to give, selectively and quantitatively the corresponding 2-dialkylamino-4-chloroquinazolines 5 .

Direct Synthesis of 2-Substituted 5-Formylpyrimidines and Ring Transformation of Their Phenylhydrazones into 4-Formyl-1-phenylpyrazole

Triformylmethane reacted with benzamidine, guanidine and S-methylisothiourea to give 2-substituted 5-formylpyrimidines, whose phenylhydrazones readily underwent ring transformation into 4-formyl-1-phenylpyrazole on heating in acidic methanol

A new “one pot” preparation of 2-n,n-dialkylamino-1,3-benzoxazines and naphth[ 1,2-e][ 1,3]oxazines from corresponding ortho hydroxynitriles and phosgeniminium salts

Abstract Phosgeniminium salts 2 react easily with ortho hydroxybenzonitriles 1 and 2-hydroxy-1-naphthonitriles 6 to give 1,3-benzoxazine and naphth[1,2- e ][1,3]oxazine derivatives respectively with a very good yield.

A NEW ONE‐FLASK PREPARATION OF 2‐(ALKYLAMINO)‐4‐CHLOROQUINAZOLINES FROM O‐AMINOBENZONITRILES AND PHOSGENIMINIUM SALTS

Aus den 2-Amino-benzonitrilen (I) entstehen mit den Phosgeniminium-Salzen (II) uber die isolierbaren Zwischenstufen (III) direkt die 2-Alkylamino-4-chlor-chinazoline (IV).

Synthesis of 7,10- and 7,8-dimethylbenz[c]acridine

7,10-Dimethylbenz[c]acridine, commonly used in experimental cancerology, is shown to be a mixture with 7,8-dimethylbenz[c]acridine. Unambiguous syntheses of these two dimethylbenz[c]acridine are described.