Mieko Hata

Allergic contact dermatitis from curcumin (turmeric)

Discussion Neticonazole, a vinyl imidazole derivative (Fig. 2), is a newly developed antifungal drug in use since 1995. Contact allergy due to neticonazole has not been reported in the literature. Another vinyl imidazole, croconazole, has caused contact sensitivity (I). Cross-sensitization between 2-(2,4-dichlorophenyl)-ethyl imidazoles, e.g. econazole, isoconazole, miconazole, oxiconazole, and sulconazole, is well-known (2-5). Our case cross-reacted to econazole and sulconazole, but not to croconazole, suggesting that the vinyl base may not be related to the antigenic determinant. Non-imidazole drugs (morpholine, benzylamine, or allylamine) should be prescribed in these patients.

Histologic effects of ruby laser hair removal in Japanese patients

Hair removal by lasers has recently become a popular method to remove unwanted hair. However, histologic changes in human skin before and after exposure to lasers have not been thoroughly investigated. The aim of this study was to clarify the differences that occur immediately after laser exposure and 1 month after laser exposure.

Fixed-drug eruption caused by allylisopropylacetylurea

Keywords: fixed drug eruption; allylisopropylacetylurea; positive lesional patch test; bromvalerylurea; cross-sensitization; cutaneous adverse drug reactions; hypnotics and sedatives

A case of renal cancer discovered by multiple skin transition.

A 74-year-old female with skin metastasis of renal cell carcinoma is described.She noticed her cutaneous lesion on her left lower abdomen about three years before visiting our dermatological outpatient clinic. The lesion gradually enlarged and multiple nodule developed on the other parts of the body.The biopsy was taken from the lesion on the right arm. On microscopic findings, the metastasis of renal cell carcinoma was suggested. An examination of whole body was performed and renal cell carcinoma of left kidney was discovered. Systemic and multi-organ involvement were also observed.This case is rare because the patient had a large number of metastatic skin lesions up to 62. In addition, she lived at least 3 years after the metastasis of the skin. It is relatively a long period for the patient with metastatic renal cell carcinoma.