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Mitsuya Sakurai

Tokyo Institute of Technology

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Publication

Featured researches published by Mitsuya Sakurai.

Tetrahedron Letters | 1993

A new synthetic route for the γ-lactone precursors of hydroxyethylene dipeptide isosteres

Mitsuya Sakurai; Tadashi Hata; Yuichiro Yabe

Abstract δ-Phthalimido-γ-ketoesters were obtained by the Pd catalysed coupling reaction between acid chlorides and organozinc reagents derived from β-iodoesters, and were converted into the γ-lactone precursors of Phe-ψ[H.E.]-Ala and Phe-ψ [H.E.]-Pro ( 15a,b–18a,b ).

Journal of The Chemical Society, Chemical Communications | 1992

An efficient synthesis of γ-lactones as precursors of hydroxyethylene dipeptide isostere

Mitsuya Sakurai; Fujio Saito; Yasuo Ohata; Yuichiro Yabe; Takahide Nishi

An efficient and stereocontrolled synthesis of γ-lactones as precursors of the hydroxyethylene dipeptide isostere has been developed, starting from readily available 5-oxotetrahydrofuran-2-carboxylic acid 6.

Archive | 1992

New beta-amino-alpha-hydroxycarboxylic acids and their use

Yuichiro Yabe; Mitsuya Sakurai; Susumu Higashida; Tomoaki Komai; Takashi Nishigaki; Hiroshi Handa

Archive | 2000

Amidocarboxylic acid derivatives

Hiroaki Yanagisawa; Mitsuya Sakurai; Makoto Takamura; Toshihiko Fujiwara

Bioorganic & Medicinal Chemistry | 1994

Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA

Mitsuya Sakurai; Susumu Higashida; Machiko Sugano; Tomoaki Komai; Ryuichi Yagi; Yuji Ozawa; Hiroshi Handa; Takashi Nishigaki; Yuichiro Yabe

Bioorganic & Medicinal Chemistry | 2004

Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents

Makoto Takamura; Mitsuya Sakurai; Eriko Yamada; Sachie Fujita; Makoto Yachi; Toshiyuki Takagi; Aya Isobe; Yuka Hagisawa; Toshihiko Fujiwara; Hiroaki Yanagisawa

Chemical & Pharmaceutical Bulletin | 1990

Syntheses and Biological Activities of Renin Inhibitors Containign Statine Analogues

Takahide Nishi; Fujio Saito; Hitoshi Nagahori; Mitsuru Kataoka; Yasuhiro Morisawa; Yuichiro Yabe; Mitsuya Sakurai; Susmu Higashida; Machiko Shoji; Yoichi Matsushita; Yasuteru Iijima; Kiyoshi Ohizumi; Hiroyuki Koike

Bioorganic & Medicinal Chemistry | 1996

Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA—II. Modification of pyrrolidine ring at P1′ proline

Tomoaki Komai; Susumu Higashida; Mitsuya Sakurai; Tamayo Nitta; Atsushi Kasuya; Shuichi Miyamaoto; Ryuichi Yagi; Yuji Ozawa; Hiroshi Handa; Hiroshi Mohri; Akira Yasuoka; Shinichi Oka; Takashi Nishigaki; Satoshi Kimura; Kaoru Shimada; Yuichiro Yabe

Chemical & Pharmaceutical Bulletin | 1989

Asymmetric Synthesis of 2-Substituted-3-aminocarbonyl Propionic Acid

Takahide Nishi; Mitsuya Sakurai; Sadao Sato; Mitsuru Kataoka; Yasuhiro Morisawa

Chemical & Pharmaceutical Bulletin | 1993

Studies of HIV-1 Protease Inhibitors. I.Incorporation of a Reduced Peptide, Simple Aminoalcohol, and Statine Analog at the Scissile Site Substrate Sequences

Mitsuya Sakurai; Machiko Sugano; Hiroshi Handa; Tomoaki Komai; Ryuichi Yagi; Takashi Nishigaki; Yuichiro Yabe

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Yuichiro Yabe

Tokyo Institute of Technology

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Hiroshi Handa

Tokyo Medical University

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Takashi Nishigaki

Tokyo Institute of Technology

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Tomoaki Komai

Tokyo Institute of Technology

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Susumu Higashida

Tokyo Institute of Technology

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Ryuichi Yagi

Tokyo Institute of Technology

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Machiko Sugano

Tokyo Institute of Technology

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Takahide Nishi

Tokyo Institute of Technology

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Fujio Saito

Tokyo Institute of Technology

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Hiroaki Yanagisawa

Daiichi Sankyo

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