Susumu Higashida | Researchain

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Archive | 1992

New beta-amino-alpha-hydroxycarboxylic acids and their use

Yuichiro Yabe; Mitsuya Sakurai; Susumu Higashida; Tomoaki Komai; Takashi Nishigaki; Hiroshi Handa

Bioorganic & Medicinal Chemistry | 1994

Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA

Mitsuya Sakurai; Susumu Higashida; Machiko Sugano; Tomoaki Komai; Ryuichi Yagi; Yuji Ozawa; Hiroshi Handa; Takashi Nishigaki; Yuichiro Yabe

Bioorganic & Medicinal Chemistry | 1996

Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA—II. Modification of pyrrolidine ring at P1′ proline

Tomoaki Komai; Susumu Higashida; Mitsuya Sakurai; Tamayo Nitta; Atsushi Kasuya; Shuichi Miyamaoto; Ryuichi Yagi; Yuji Ozawa; Hiroshi Handa; Hiroshi Mohri; Akira Yasuoka; Shinichi Oka; Takashi Nishigaki; Satoshi Kimura; Kaoru Shimada; Yuichiro Yabe

Chemistry Letters | 1985

Short chain peptide inhibitors of human renin

Rei Matsueda; Yuichiro Yabe; Hiroshi Kogen; Susumu Higashida; Hiroyuki Koike; Yasuteru Iijima; Tatsuo Kokubu; Kunio Hiwada; Eiki Murakami; Yoichi Imamura

Chemical & Pharmaceutical Bulletin | 1994

Studies of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitors. III. Structure-Activity Relationship of HIV-1 Protease Inhibitors Containing Cyclohexylalanylalanine Hydroxyethylene Dipeptide Isostere

Mitsuya Sakurai; Susumu Higashida; Machiko Sugano; Hiroshi Handa; Tomoaki Komai; Ryuichi Yagi; Takashi Nishigaki; Yuichiro Yabe

Chemical & Pharmaceutical Bulletin | 1993

Studies of HIV-1 Protease Inhibitors. II.Incorporation of Four Types of Hydroxyethylene Dipeptide Isosteres at the Scissile Site of Substrate Sequences

Mitsuya Sakurai; Susumu Higashida; Machiko Sugano; Takahide Nishi; Fujio Saito; Yasuo Ohata; Hiroshi Handa; Tomoaki Komai; Ryuichi Yagi; Takashi Nishigaki; Yuichiro Yabe

Archive | 1994

Inhibitors of HIV protease

Susumu Higashida; Mitsuya Sakurai; Yuichiro Yabe; Takashi Nishigaki; Tomoaki Komai; Hiroshi Handa

Biological & Pharmaceutical Bulletin | 1997

In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid.

Tomoaki Komai; Ryuichi Yagi; Hisayo Suzuki-Sunagawa; Mitsuya Sakurai; Susumu Higashida; Machiko Sugano; Hiroshi Handa; Hiroshi Mohri; Akira Yasuoka; Shinichi Oka; Yuichiro Yabe; Takashi Nishigaki; Satoshi Kimura; Kaoru Shimada

Heterocycles | 2000