Mohammed Ibrahim
Deccan College of Medical Sciences
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Publication
Featured researches published by Mohammed Ibrahim.
International Journal of Endocrinology | 2010
Mohammed Fazil Ahmed; Syed Mohammed Kazim; Syed Safiullah Ghori; Syeda Sughra Mehjabeen; Shaik Rasheed Ahmed; Shaik Mehboob Ali; Mohammed Ibrahim
The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of β-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.
journal of applied pharmaceutical science | 2012
A. Srinivasa Rao; Mohammed Fazil Ahmed; Mohammed Ibrahim
The aim of the study is to investigate the hepatoprotective activity of Melia azedarach L leaves extracts against simvastatin induced hepatotoxicity. The phytochemical screening was carried on the leaves extracts of Melia azedarach revealed the presence of some active ingredients such as Alkaloids, Tannins, Sponginess, Phenols, glycosides, steroids, terpenoids and flavonoids. Leaves of Melia azedarach was successively extracted with ethanol against simvastatin (20mg/kg.p.o) induced hepatotoxicity using Standard drug Silymarin (25 mg/kg). There was a significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP),serum bilirubin and decrease the total proteins content.) in simvastatin treated rats, which were restored towards normalization in Melia azedarach (300 mg/kg and 500 mg/kg) treated animals. Thus the present study ascertains that the leaf extract of Melia azedarach possesses significant hepatoprotective activity.
Pharmacognosy Journal | 2010
Mohammed Fazil Ahmed; A. Srinivasa Rao; A Hameed Thayyil; S Rasheed Ahemad; Muna Abid; Mohammed Ibrahim
Abstract The present study was carried out to evaluate the anti-ulcer activity of cassia auriculata leaf extract against pylorous ligation induced gastric ulcer. The methanolic leaf extract of cassia auriculata at dose of 300 mg/kg p.o. markedly decrease the incidence of ulcers in pyloric ligatied rats. In pyloric ligated rats, there was an increase in the gastric volume, free and total acidity and ulcerative index as compared to the control group. The methanolic leaf extract of cassia auriculata at dose of, 300 mg/kg showed significant reduction in the above parameters which was comparable to the standard drug famotidine(10 mg/kg). Cassia auriculata extract showed protection index 79.4 %, whereas standard drug famotidine showed protection index 90.7%.
Clinical and Experimental Gastroenterology | 2012
M Srinivasa Rao; B Syed Asad; Ma Fazil; Rd Sudharshan; Sa Rasheed; Ha Pradeep; S Aboobacker; Ah Thayyil; Ak Riyaz; M Mansoor; Ma Aleem; K Zeeyauddin; M Lakshmi Narasu; A Anjum; Mohammed Ibrahim
Aim This investigation aimed to assess the hepatoprotective effect of saponin fraction isolated from the fruit pericarp of Sapindus mukorossi on carbon tetrachloride (CCl4)-induced hepatotoxicity. Methods Fruit of S. mukorossi was collected and authenticated, and dried pericarp powder subjected to extraction with cold ethanol (70%) by maceration followed by isolation of total saponin fraction. Hepatoprotective activity was demonstrated in the CCl4-damaged primary monolayer culture. In in vivo studies, pretreatment with total saponin fraction (50,100 and 150 mg/kg per os once a day for 4 days before CCl4 introduction and continued afterward for 3 days) attenuated the CCl4-induced acute increase in serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, and alkaline phosphatase activities and considerably reduced histopathological alterations. Further, saponin fraction reduced thiopentone-induced (4 mg/kg, intraperitoneal) sleeping time in rats. Results Saponin fraction pretreatment improves bromsulphalein clearance and also increases cellular viability. Saponin administration replenished depleted hepatic glutathione and superoxide dismutase by improving the antioxidant status of the liver and liver function enzymes. These effects substantiate protection of cellular phospholipids from peroxidative damage induced by highly reactive toxic intermediate radicals formed during biotransformation of CCl4. Conclusion The above findings lead to the conclusion that the saponin fraction of S. mukorossi has a protective capability both in vitro on primary hepatocyte cultures and in vivo in a rat model of CCl4-mediated liver injury. Hence, we suggest that the inclusion of this S. mukorossi fruit pericarp in the management of liver disorders is justified.
World Journal of Gastroenterology | 2008
Mohammed Ibrahim; Mohammed Nane Khaja; Anjum Aara; Aleem Ahmed Khan; Mohammed Aejaz Habeeb; Yalavarthy Prameela Devi; Mangamoori Lakshmi Narasu; Chitoor Mohammed Habibullah
World Journal of Gastroenterology | 2006
Mohammed Ibrahim; Aleem Ahmed Khan; Santosh K. Tiwari; Mohammed Aejaz Habeeb; Mohammed Nane Khaja; C. M. Habibullah
World Journal of Gastroenterology | 2009
Hulikere Ananth Pradeep; Saleemullah Khan; Karamkonda Ravikumar; Mohammed Fazil Ahmed; Meesala Srinivasa Rao; Mandava Kiranmai; Dachani Sudhershan Reddy; Shaik Rasheed Ahamed; Mohammed Ibrahim
Archive | 2012
Mohammed Fazil Ahmed; A. Srinivasa Rao; Shaik Rasheed Ahemad; Mohammed Ibrahim
Journal of Medical and Allied Sciences | 2011
Khaja Zeeyauddin; Mangamoori Lakshmi Narsu; Muna Abid; Mohammed Ibrahim
Polymer Journal | 2011
Mohammed Fazil Ahmed; A. Srinivasa Rao; Hameed Thayyil; Shaik Rasheed Ahemad; Mohammed Ibrahim