Mustanir

Isolation Compound Anti-Obesity from the Bark Ara (Ficus Racemosa) of Aceh

The extract n-hexane and ethyl acetate obtained from plants Ficus racemosa, respectively of 68.50 g (2.28%) and 50.52 g (1.68%), were tested their antiobesity, with dose of 100, 500, 1000 and 1500 mg / kg bw of mice. The results showed that the extract n-hexane and ethyl acetate can weight loss in mice, obtained optimal dose is 1500 mg / kg bwof mice and used as dosis of next work. Furthermore, 30 g of ethyl acetate extract were fractionated, and yielding three groups of fractions, namely fraction groups A, B and C.Test antiobesity against the fractions A, B, and C were carried out for 5 days each using three mice, can decrease mice weight of average : 2.89%; 2.57%; 0.56% while 4.14% for positive control, whereas the negative control mice increase weight of mice as much as 4.82%. Fraction A, after separated with chromatography produce a compound suspected of β-amyrin acetate. Compounds β-amyrin acetate at a dose of 1500 mg / kg bw of mice, showed a weight loss of 2.31%. β-amyrin acetate compound was characterized by Mass Spectrometry (MS), Proton Nuclear Magnetic Resonance (1H-NMR) and Fourier Transform Infrared Spectroscopy (FT-IR). keywords: anti-obesity, Ficus racemosa, isolation, β-amyrin acetate.