Natalia I. Zabolotna

Mueller-matrix diagnostics of optical properties of polycrystalline networks of human blood plasma

The work is oriented toward a study of the possibilities of Mueller-matrix diagnostics of optical anisotropy of birefringent polycrystalline networks of human plasma amino acids. The interrelations between the statistical moments from the first to the fourth orders and fractal dimensionalities, which characterize the coordinate distributions of elements of the Mueller matrix for the blood plasma and the physiological state of the human organism, are determined.

Diagnostic efficiency of Mueller-matrix polarization reconstruction system of the phase structure of liver tissue

The application field of using the Mueller-matrix polarizing reconstruction system of phase structure of biological layer for optical-anisotropic parameters differentiation of histological sections of healthy and rat’s liver with hepatitis were investigated. Comparison of system informativity with known systems on indexes of sensitivity, specificity and balanced accuracy were performed.

A fractal and statistic analysis of Mueller-matrix images of phase inhomogeneous layers

The paper is aimed at researching the effectiveness of differentiation of optical anisotropic property of biological crystal networks by means of the statistic and correlation analysis of new analytical parameter - the degree of mutual correlation of biological tissues Mueller matrices of different morphological structure and physiological state.

The Mueller-matrix elements characteristic values of biological tissues

In this work, we have theoretically grounded conceptions of characteristics points observed in coordinate distributions of Mueller matrix elements for a network of human tissue biological crystals. Found is interrelation between polarization singularities of laser images inherent to these biological crystals and characteristic values of above matrix elements. We have determined criteria for statistical diagnostics of pathological changes in the birefringent structure of biological crystal network by using myometrium tissue as an example.

Processing and analysis of images in the multifunctional classification laser polarimetry system of biological objects

The Jones matrix mapping of blood plasma films was considered in this paper. The statistical analysis (statistical moments of the 1st - 4th orders) of the obtained elements was carried out. To increase the accuracy and reliability of the diagnosis, the number of informative indicators was increased due to the correlation analysis. which increased the number of inputs to 8. The differentiation of nosologies was based on the rules of fuzzy logic.

System of Mueller-Jones matrix polarizing mapping of blood plasma films in breast pathology

The combined method of Jones-Mueller matrix mapping and blood plasma films analysis based on the system that proposed in this paper. Based on the obtained data about the structure and state of blood plasma samples the diagnostic conclusions can be make about the state of breast cancer patients (“normal” or “pathology”). Then, by using the statistical analysis obtain statistical and correlational moments for every coordinate distributions; these indicators are served as diagnostic criterias. The final step is to comparing results and choosing the most effective diagnostic indicators. The paper presents the results of Mueller-Jones matrix mapping of optically thin (attenuation coefficient ,τ≤0,1) blood plasma layers.

In-vivo monitoring of oxygen saturation in murine carcinoma during PDT by diode laser light diffuse reflectance

In the paper we explored the possibility of monitoring oxygenation of the tumor tissue through the registration of light diffuse reflectance. This method can also be helpful for assessment the effectiveness of PDT, defining the level of vascular damage and the degree of the tumor oxygenation. We also propose the modification of PDT procedure by using a modulated laser that enables to better maintain the necessary parameters for the PS activation and oxygen generation in irradiated tissues simultaneously allowing to reduce the light dose required for tumor treatment.

Quality improvement of diagnosis of the electromyography data based on statistical characteristics of the measured signals

Research and systematization of motor disorders, taking into account the clinical and neurophysiologic phenomena, are important and actual problem of neurology. The article describes a technique for decomposing surface electromyography (EMG), using Principal Component Analysis. The decomposition is achieved by a set of algorithms that uses a specially developed for analyze EMG. The accuracy was verified by calculation of Mahalanobis distance and Probability error.

System of polarization phasometry of polycrystalline blood plasma networks in mammary gland pathology diagnostics

The polarizing phase meter system of polycrystalline networks of human blood plasma which is used for the mammary gland pathology diagnostics was proposed in this paper. Increasing the accuracy of the phase value determination was achieved using a combination of low coherent source of radiation and circularly polarized probing of biological object. Thus, high informativity of polarizing phase meter system for the diagnosis of breast pathology using the phase mapping of the human blood plasma films were determined, thereafter statistical, correlational, fractal structure analysis of the obtained phase maps was carried out and the quantitative criterias of the phase diagnostics and differentiation of the breast pathological conditions were determined too.

System of the phase tomography of optically anisotropic polycrystalline films of biological fluids

The theoretical background of azimuthally stable method Jones matrix mapping of histological sections of biopsy of uterine neck on the basis of spatial-frequency selection of the mechanisms of linear and circular birefringence is presented. The comparative results of measuring the coordinate distributions of complex degree of mutual anisotropy formed by fibrillar networks of myosin and collagen fibrils of uterine neck tissue of different pathological states - precancer (dysplasia) and cancer (adenocarcinoma) are shown. The values and ranges of change of the statistical (moments of the 1st - 4th order) parameters of complex degree of mutual anisotropy coordinate distributions are studied. The objective criteria of diagnostics of the pathology and differentiation of its severity degree are determined.