P. Desaulles

Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch Cortisone

A method is described which makes quantitative studies of the action of Cortisone on connective tissue possible. Foreign body granulomas are provoked in rats by subcutaneous implantation of pellets of compressed cotton. Application of Cortisone results in a diminution of granuloma formation, which can be expressed quantitatively by determining the fresh and the dry weight. Cortisone was effective by local as well as by general application, similar concentrations producing the same degree of inhibition of connective tissue.

Elektrocortin-Wirkung im Glykogentest

Elektrocortin is 30 times as active as Desoxycorticosterone in raising the liver glycogen to the same degree.

Vergleich der Wirkung des Aldosterons auf das Fremdkörpergranulom der Ratte mit derjenigen von Cortexon, Corticosteron, Cortison und Hydrocortison

Aldosterone applied locally in doses of 50–100 γ enhances slightly the growth of granuloma and in doses of up to 200 γ fails to inhibit such growth. In the doses, then, its action differs from that of hydrocortisone, cortisone, and cortexone.

Preliminary note on certain pharmacological properties of 3β, 16α-dihydroxyallopregnan-20-one

3β, 16α- Dihydroxyallopregnan-20-one hat die Eigenschaft, bei der Mehrzahl adrenopriver, salzbelasteter Ratten im Harn eine Natrium-Mehrausscheidung hervorzurufen.

Unabhängigkeit der Bildung des Fremdkörpergranuloms und seiner Beeinflussung durch Compound E von der Hypophyse

Experiments have been carried out with the method already described to study the influence of Cortisone on development of foreign body granuloma. The formation of foreign body granuloma and its inhibition by Cortisone are independent of the influence of the hypophysis. It has been found that the granuloma develops in the same way in the hypophysectomized animal as in the normal one. Although in the hypophysectomized animal the inhibition produced by Cortisone is of identical type and degree, it could be concluded that most processes are independent of the influence of the hypophysis.

Structure and activity of corticotrophic peptides: Synthesis and biological activity of two corticotrophic peptides with neutral amino acids in positions 17 and 18

[D-Ser1, Nva17,18]-β-Corticotropin-(1-19)-nonadecapeptidamid Xa und [D-Ser1, Nle17,18]-β-Corticotropin-(1-19)-nonadecapeptidamid Xb wurden synthetisiert und ihre biologischen Aktivitäten diskutiert.

Wirkung eines tumorhemmenden Stoffes, des Triäthylenmelamins, auf das Wachstum von Fremdkörpergranulom und Tumor

The action of Triethylenmelamine, an anti-tumour substance, was investigated on tumourgrowth and on development of the foreign body granuloma comparatively. It was found that this substance induces in both cases a similar dosis-dependent inhibition of growth. As the inhibiting action of Triethylenmelamine can even be demonstrated on rapidly growing normal tissues, it is questionable whether the antagonistic action against tumour can be designed as tumour-specific.

Über die Entwicklung des Fremdkörpergranuloms in verschiedenen Organsystemen

The weight has been measured of the granuloma produced after implantation of the same foreign body in the kidneys, the testes, the liver and the subcutaneous tissue of male rats. It was found that granulomae in the testes and liver are nearly twice as heavy as in the kidney or in the subcutaneous tissue. Enhancement or inhibition of this reaction by treating the animals with cortexone shows organ-dependent effects on granuloma formation.

Über die Wirkung von Mischungen eines antigenhaltigen Plasmas mit einem antikörperhaltigen Serum auf die Entwicklung des Fremdkörpergranuloms

It has been shown that local application of a mixture of precipitating antiserum with homologous plasma or serum promotes markedly the growth of granuloma tissue in the rat.

The action of sex hormones on endometrial secretion in spayed rats sensitized to oestradiol.

Ligatur der distalen Enden der Uterushörner von adulten, kastrierten, mit Östradiol sensibilisierten Ratten hat eine Ansammlung der uterinen Flüssigkeit zur Folge. Die Wirkung von Östradiol, Testosteron und Progesteron auf die Eigenschaften dieser Flüssigkeit wurde untersucht. Während Östradiol in verschiedenen Dosen keinen signifikanten Effekt aufweist, zeigt Testosteron und besonders Progesteron eine ausgeprägte Wirkung. Sie reduzieren die Menge der Flüssigkeit, erniedrigen das pH und steigern die Viskosität. Diese Veränderungen könnten für die Hemmung der Fertilität durch diese Substanzen von Bedeutung sein.