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Featured researches published by Paul A. Jones.


Journal of Exposure Science and Environmental Epidemiology | 2005

Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments

Marsha K. Morgan; Linda Sheldon; Carry Croghan; Paul A. Jones; Gary L Robertson; Jane C Chuang; Nancy K. Wilson; Christopher Lyu

As part of the Childrens Total Exposure to Persistent Pesticides and Other Persistent Organic Pollutants (CTEPP) study, we investigated the exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol (TCP) in their everyday environments. During this study, the participants were still able to purchase and apply chlorpyrifos at their homes or day care centers. Participants were recruited randomly from 129 homes and 13 day care centers in six North Carolina counties. Monitoring was performed over a 48-h period at the childrens homes and/or day care centers. Samples that were collected included duplicate plate, indoor and outdoor air, urine, indoor floor dust, play area soil, transferable residues (PUF roller), and surface wipes (hand, food preparation, and hard floor). The samples were extracted and analyzed by gas chromatography/mass spectrometry. Chlorpyrifos was detected in 100% of the indoor air and indoor floor dust samples from homes and day care centers. TCP was detected at homes and day care centers in 100% of the indoor floor dust and hard floor surface wipe, in >97% of the solid food, and in >95% of the indoor air samples. Generally, median levels of chlorpyrifos were higher than those of TCP in all media, except for solid food samples. For these samples, the median TCP concentrations were 12 and 29 times higher than the chlorpyrifos concentrations at homes and day care centers, respectively. The median urinary TCP concentration for the preschool children was 5.3 ng/ml and the maximum value was 104 ng/ml. The median potential aggregate absorbed dose (ng/kg/day) of chlorpyrifos for these preschool children was estimated to be 3 ng/kg/day. The primary route of exposure to chlorpyrifos was through dietary intake, followed by inhalation. The median potential aggregate absorbed dose of TCP for these children was estimated to be 38 ng/kg/day, and dietary intake was the primary route of exposure. The median excreted amount of urinary TCP for these children was estimated to be 117 ng/kg/day. A full regression model of the relationships among chlorpyrifos and TCP for the children in the home group explained 23% of the variability of the urinary TCP concentrations by the three routes of exposure (inhalation, ingestion, dermal absorption) to chlorpyrifos and TCP. However, a final reduced model via step-wise regression retained only chlorpyrifos through the inhalation route and explained 22% of the variability of TCP in the childrens urine. The estimated potential aggregate absorbed doses of chlorpyrifos through the inhalation route were low (median value, 0.8 ng/kg/day) and could not explain most of the excreted amounts of urinary TCP. This suggested that there were other possible sources and pathways of exposure that contributed to the estimated potential aggregate absorbed doses of these children to chlorpyrifos and TCP. One possible pathway of exposure that was not accounted for fully is through the childrens potential contacts with contaminated surfaces at homes and day care centers. In addition, other pesticides such as chlorpyrifos-methyl may have also contributed to the levels of TCP in the urine. Future studies should include additional surface measurements in their estimation of potential absorbed doses of preschool children to environmental pollutants. In conclusion, the results showed that the preschool children were exposed to chlorpyrifos and TCP from several sources, through several pathways and routes.


Environmental Science & Technology | 2011

Assessing the Quantitative Relationships between Preschool Children’s Exposures to Bisphenol A by Route and Urinary Biomonitoring

Marsha K. Morgan; Paul A. Jones; Antonia M. Calafat; Xiaoyun Ye; Carry Croghan; Jane C Chuang; Nancy K. Wilson; Matthew Scott Clifton; Zaida Figueroa; Linda S. Sheldon

Limited published information exists on young childrens exposures to bisphenol A (BPA) in the United States using urinary biomonitoring. In a previous project, we quantified the aggregate exposures of 257 preschool children to BPA in environmental and personal media over 48-h periods in 2000-2001 at homes and daycares in North Carolina and Ohio. In the present study for 81 Ohio preschool children ages 23-64 months, we quantified the childrens urinary total BPA (free and conjugated) concentrations over these same 48-h periods in 2001. Then, we examined the quantitative relationships between the childrens intakes doses of BPA through the dietary ingestion, nondietary ingestion, and inhalation routes and their excreted amounts of urinary BPA. BPA was detected in 100% of the urine samples. The estimated median intake doses of BPA for these 81 children were 109 ng/kg/day (dietary ingestion), 0.06 ng/kg/day (nondietary ingestion), and 0.27 ng/kg/day (inhalation); their estimated median excreted amount of urinary BPA was 114 ng/kg/day. Our multivariable regression model showed that dietary intake of BPA (p = 0.04) and creatinine concentration (p = 0.004) were significant predictors of urinary BPA excretion, collectively explaining 17% of the variability in excretion. Dietary ingestion of BPA accounted for >95% of the childrens excreted amounts of urinary BPA.


Journal of Exposure Science and Environmental Epidemiology | 2010

Assessment of a pesticide exposure intensity algorithm in the agricultural health study

Kent Thomas; Mustafa Dosemeci; Joseph Coble; Jane A. Hoppin; Linda Sheldon; Guadalupe Chapa; Carry Croghan; Paul A. Jones; Charles Knott; Charles F. Lynch; Dale P. Sandler; Aaron Blair; Michael C. R. Alavanja

The accuracy of the exposure assessment is a critical factor in epidemiological investigations of pesticide exposures and health in agricultural populations. However, few studies have been conducted to evaluate questionnaire-based exposure metrics. The Agricultural Health Study (AHS) is a prospective cohort study of pesticide applicators who provided detailed questionnaire information on their use of specific pesticides. A field study was conducted for a subset of the applicators enrolled in the AHS to assess a pesticide exposure algorithm through comparison of algorithm intensity scores with measured exposures. Pre- and post-application urinary biomarker measurements were made for 2,4-D (n=69) and chlorpyrifos (n=17) applicators. Dermal patch, hand wipe, and personal air samples were also collected. Intensity scores were calculated using information from technician observations and an interviewer-administered questionnaire. Correlations between observer and questionnaire intensity scores were high (Spearmans r=0.92 and 0.84 for 2,4-D and chlorpyrifos, respectively). Intensity scores from questionnaires for individual applications were significantly correlated with post-application urinary concentrations for both 2,4-D (r=0.42, P<0.001) and chlorpyrifos (r=0.53, P=0.035) applicators. Significant correlations were also found between intensity scores and estimated hand loading, estimated body loading, and air concentrations for 2,4-D applicators (r-values 0.28–0.50, P-values<0.025). Correlations between intensity scores and dermal and air measures were generally lower for chlorpyrifos applicators using granular products. A linear regression model indicated that the algorithm factors for individual applications explained 24% of the variability in post-application urinary 2,4-D concentration, which increased to 60% when the pre-application urine concentration was included. The results of the measurements support the use of the algorithm for estimating questionnaire-based exposure intensities in the AHS for liquid pesticide products. Refinement of the algorithm may be possible using the results from this and other measurement studies.


Journal of Exposure Science and Environmental Epidemiology | 2008

Adult and children's exposure to 2,4-D from multiple sources and pathways

Marsha K. Morgan; Linda Sheldon; Kent Thomas; Peter P. Egeghy; Carry Croghan; Paul A. Jones; Jane C Chuang; Nancy K. Wilson

In this study, we investigated the 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide exposures of 135 preschool-aged children and their adult caregivers at 135 homes in North Carolina (NC) and Ohio (OH). Participants were randomly recruited from six NC and six OH counties. Monitoring was performed over a 48-h period at the participants’ homes. Environmental samples included soil, outdoor air, indoor air, and carpet dust. Personal samples collected by the adult caregivers concerning themselves and their children consisted of solid food, liquid food, hand wipe, and spot urine samples. All samples were analyzed for 2,4-D (free acid form) by gas chromatography/mass spectrometry. 2,4-D was detected in all types of environmental samples but most often in carpet dust samples, with detection frequencies of 83% and 98% in NC and OH, respectively. The median level of 2,4-D in the carpet dust samples was about three times higher in OH homes compared to NC homes (156 vs. 47.5 ng/g, P<0.0002). For personal samples, 2,4-D was more frequently detected in the hand wipe samples from OH participants (>48%) than from NC participants (<9%). Hand wipe levels at the 95th percentile were about five times higher for OH children (0.1 ng/cm2) and adults (0.03 ng/cm2) than for the NC children (0.02 ng/cm2) and adults (<0.005 ng/cm2). 2,4-D was detected in more than 85% of the child and adult urine samples in both states. The median urinary 2,4-D concentration was more than twice as high for OH children compared to NC children (1.2 vs. 0.5 ng/ml, P<0.0001); however, the median concentration was identical at 0.7 ng/ml for both NC and OH adults. The intraclass correlation coefficient of reliability for an individuals urinary 2,4-D measurements, estimated from the unadjusted (0.31–0.62) and specific gravity-adjusted (0.37–0.73) values, were somewhat low for each group in this study. The variability in urinary 2,4-D measurements over the 48-h period for both children and adults in NC and OH suggests that several spot samples were needed to adequately assess these participants’ exposures to 2,4-D in residential settings. Results from this study showed that children and their adult caregivers in NC and OH were likely exposed to 2,4-D through several pathways at their homes. In addition, our findings suggest that the OH children might have been exposed to higher levels of 2,4-D through the dermal and nondietary routes of exposure than the NC children and the NC and OH adults.


Journal of Exposure Science and Environmental Epidemiology | 2011

The reliability of using urinary biomarkers to estimate children's exposures to chlorpyrifos and diazinon.

Marsha K. Morgan; Linda Sheldon; Paul A. Jones; Carry Croghan; Jane C Chuang; Nancy K. Wilson

A few studies have reported concurrent levels of chlorpyrifos (CPF) and diazinon (DZN) and their environmentally occurring metabolites, 3,5,6-trichloro-2-pyridinol (TCP) and 2-isopropyl-6-methyl-4-pyrimidinol (IMP), in food and in environmental media. This information raises questions regarding the reliability of using these same metabolites, TCP and IMP, as urinary biomarkers to quantitatively assess the everyday exposures of children to CPF and DZN, respectively. In this study, we quantified the distributions of CPF, DZN, TCP, and IMP in several environmental and personal media at the homes and day-care centers of 127 Ohio preschool children and identified the important sources and routes of their exposures. The children were exposed to concurrent levels of these four chemicals from several sources and routes at these locations. DZN and IMP were both detected above 50% in the air and dust samples. CPF and TCP were both detected in greater than 50% of the air, dust (solid), food, and hand wipe samples. TCP was detected in 100% of the urine samples. Results from our regression models showed that creatinine levels (<0.001), and dietary (P<0.001) and inhalation (P<0.10) doses of TCP were each significant predictors of urinary TCP, collectively explaining 27% of the urinary TCP variability. This information suggests that measurement of urinary TCP did not reliably allow quantitative estimation of the childrens everyday environmental exposures to CPF.


Environmental Research | 2008

An observational study of the potential for human exposures to pet-borne diazinon residues following lawn applications

Marsha K. Morgan; Daniel M. Stout; Paul A. Jones; Dana B. Barr

This study examined the potential for pet dogs to be an important pathway for transporting diazinon residues into homes and onto its occupants following residential lawn applications. The primary objectives were to investigate the potential exposures of occupants and their pet dogs to diazinon after an application to turf at their residences and to determine if personal contacts between occupants and their pet dogs resulted in measurable exposures. It was conducted from April to August 2001 before the Agency phased out all residential uses of diazinon in December 2004. Six families and their pet dogs were recruited into the study. Monitoring was conducted at pre-, 1, 2, 4, and 8 days post-application of a commercial, granular formulation of diazinon to the lawn by the homeowner. Environmental samples collected included soil, indoor air, carpet dust, and transferable residues from lawns and floors. Samples collected from the pet dogs consisted of paw wipes, fur clippings, and transferable residues from the fur by a technician or child wearing a cotton glove(s). First morning void (FMV) urine samples were collected from each child and his/her parent on each sampling day. Diazinon was analyzed in all samples, except urine, by GC-MS. The metabolite 2-isopropyl-4-methyl-6-hydroxypyrimidine (IMPy) was analyzed in the urine samples by HPLC-MS/MS. Mean airborne residues of diazinon on day 1 post-application were at least six times higher in both the living rooms (235+/-267 ng/m(3)) and childrens bedrooms (179+/-246 ng/m(3)) than at pre-application. Mean loadings of diazinon in carpet dust samples were at least 20 times greater on days 2, 4, and 8 post-application than mean loadings (0.03+/-0.04 ng/cm(2)) at pre-application. The pet dogs had over 900 times higher mean loadings of diazinon residues on their paws on day 1 post-application (88.1+/-100.1 ng/cm(2)) compared to mean loadings (<0.09 ng/cm(2)) at pre-application. The mean diazinon loadings on the fur clippings were at least 14 times higher on days 1, 2, 4, and 8 post-application than mean loadings (0.8+/-0.4 ng/cm(2)) at pre-application. For transferable residues from dog fur, the mean loadings of diazinon on the technicians cotton glove samples were the lowest before application (0.04+/-0.08 ng/cm(2)) and the highest on day 1 post-application (10.4+/-23.9 ng/cm(2)) of diazinon to turf. Urinary IMPy concentrations for the participants ranged from <0.3 to 5.5 ng/mL before application and <0.3-12.5 ng/mL after application of diazinon. The mean urinary IMPy concentrations for children or adults were not statistically different (p>0.05) at pre-application compared to post-application of diazinon to turf. The results showed that the participants and their pet dogs were likely exposed to low levels of diazinon residues from several sources (i.e., air, dust, and soil), through several pathways and routes, after lawn applications at these residences. Lastly, the pet dog appears to be an important pathway for the transfer and translocation of diazinon residues inside the homes and likely exposed occupants through personal contacts (i.e., petting).


Research Quarterly for Exercise and Sport | 2007

A pilot study using an accelerometer to evaluate a caregiver's interpretation of an infant or toddler's activity level as recorded in a time activity diary.

Nicolle S. Tulve; Paul A. Jones; Thomas McCurdy; Carry Croghan

Understanding human activities and their associated physical activity levels are important in estimating intake dose rates associated with exposure to environmental contaminants. High-energy activities increase a person’s oxygen consumption and breathing rates on a short-term basis and, if sustained, increase the person’s caloric and fluid intake rates on a longer term basis. Higher physiological rates result in increased levels of environmental contaminants passing into the body (McCurdy, 2000). Because children are generally more active than adults, it is important to relate young children’s activity levels with the environmental, biological, personal, and questionnaire data measured during an exposure assessment to accurately estimate their potential intake dose rates to chemical exposures through inhalation, dermal, and ingestion routes. It is well recognized, however, that young children’s physical activities are highly intermittent and varying in intensity, often occurring in bursts with relatively long periods of quiet respites (Vincent & Pangrazi, 2002). These bursts are particularly difficult to capture in a diary without high respondent burden (Fairweather, Reilly, Grant, Whittaker, & Paton, 1999). Various approaches have been used to characterize activity levels, including: administering doubly labeled water, accelerometry, heart rate monitoring, step counting via a pedometer, observation and/or videotaping by trained technicians, portable indirect calorimetry, survey questionnaires, retrospective interviews, and having participants (or their caregivers, in the case of young children) fill out contemporaneous activity diaries (Jensen, Butte, Wong, & Moon, 1992; Montoye, Kemper, Saris, & Washburn, 1996; Tennefors, Coward, Hernell, Wright, & Forsum, 2003). For infants and toddlers, physical activity is usually measured on a daily or longer basis using the doubly labeled water technique, but this method is expensive and requires participants to visit laboratories to measure their energy expenditure (Schoeller, 1988; 1999). Furthermore, having only 24-hr data is incompatible with our need for discrete activity-specific exposure and intake dose assessments. Daily aggregated measures of activity level, such as that obtained using doubly labeled water, do not provide the level of detail needed for the exposure and dose models used (McCurdy, 2000). Videotape and time activity diaries, supplemented by detailed interviews and questionnaires, are the most common methods used to capture activity information in the exposure assessment field. In general, these methods are labor intensive, and their objectivity has been questioned (Freeman & Saenz de Tejada, 2002). We could find only one small-scale exposure-oriented pilot field study in which children (N = 9; < 5 years) wore an accelerometer. When the accelerometer data and caregiver-coded diary entries were classified into three categories—sedentary (including sleeping), light, and moderate/vigorous—the classifications correlated well (r > .89, p < .001; Stevens, Williams, & McCurdy, 2004). A number of accelerometry field studies involving young children (age range 6–68 months) have been reported in the physiology literature. In general, these studies represent both short-term monitoring periods A Pilot Study Using an Accelerometer to Evaluate a Caregiver’s Interpretation of an Infant or Toddler’s Activity Level as Recorded in a Time Activity Diary


International Journal of Environmental Health Research | 2015

Using urinary biomarkers to evaluate polycyclic aromatic hydrocarbon exposure in 126 preschool children in Ohio.

Marsha K. Morgan; Paul A. Jones; Jon R. Sobus; Jane C. Chuang; Nancy K. Wilson

Limited data exist on exposures of young children to polycyclic aromatic hydrocarbons (PAHs) in the United States (US). The urinary metabolite of pyrene, 1-hydroxypyrene (1-OHPyr), is widely used as a biomarker of total PAH exposure. Our objectives were to quantify urinary 1-OHPyr levels in 126 preschool children over a 48-h period and to examine associations between selected sociodemographic/lifestyle factors and urinary 1-OHPyr levels. Monitoring was performed at 126 homes and 16 daycares in Ohio in 2001, and questionnaires and urine samples were collected. The median urinary 1-OHPyr level was 0.33 ng/mL. In a multiple regression model, sampling season (p = 0.0001) and natural log (ln)-transformed creatinine concentration (p = 0.0006) were highly significant predictors of ln-transformed 1-OH-Pyr concentration; cooking appliance type (p = 0.096) was a marginally significant predictor of ln(1-OHPyr). These children had higher median urinary 1-OHPyr levels compared to other US children (≤ 0.15 ng/mL) in previously published studies, which suggests possible geographical differences in PAH exposure.


Environmental Research | 2007

An observational study of 127 preschool children at their homes and daycare centers in Ohio: environmental pathways to cis- and trans-permethrin exposure.

Marsha K. Morgan; Linda Sheldon; Carry Croghan; Paul A. Jones; Jane C. Chuang; Nancy K. Wilson


Environmental Science & Technology | 2009

American Healthy Homes Survey: A National Study of Residential Pesticides Measured from Floor Wipes

Daniel M. Stout; Karen D. Bradham; Peter P. Egeghy; Paul A. Jones; Carry Croghan; Peter Ashley; Eugene Pinzer; Warren Friedman; Marielle C. Brinkman; Marcia Nishioka; David C. Cox

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Carry Croghan

United States Environmental Protection Agency

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Marsha K. Morgan

United States Environmental Protection Agency

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Jane C Chuang

Battelle Memorial Institute

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Daniel M. Stout

United States Environmental Protection Agency

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Jane C. Chuang

Battelle Memorial Institute

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Kent Thomas

United States Environmental Protection Agency

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Marcia Nishioka

Battelle Memorial Institute

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Nicolle S. Tulve

United States Environmental Protection Agency

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