Paul M. Skonezny

Total synthesis of (±) epipodophyllotoxin via a (3 + 2)-cycloaddition strategy

Abstract A total synthesis of racemic epipodophyllotoxin 1 from chalcone 6 has been developed employing a novel (3 + 2)-cycloaddition strategy to construct the correct substituent stereochemistry in aryltetralin ring B of 1 .

Copper(I)-catalyzed intramolecular cyclization reaction of 2-(2′-chlorophenyl)ethanol to give 2,3-dihydrobenzofuran

Abstract Functionalized 2,3-dihydrobenzofuran can be synthesized in good yield via an intramolecular cyclization of an aryl chloride and a primary alcohol under the catalysis of copper(I) chloride salt.

Synthesis of optically pure (S)-2-acetylthio-3-benzenepropanoic acid via enzymatic resolution

A method of synthesizing optically pure (S)-2-acetylthio-3-benzenepropanoic acid has been developed and good to excellent enantiomeric excess achieved via enzymatic resolution.