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Dive into the research topics where Thomas Franceschini is active.

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Featured researches published by Thomas Franceschini.


Journal of Industrial Microbiology & Biotechnology | 2004

Expression of a cephalosporin C esterase gene in Acremonium chrysogenum for the direct production of deacetylcephalosporin C

Jonathan D. Basch; Thomas Franceschini; Sean M. Tonzi; Shu-Jen Chiang

A recombinant fungal microorganism capable of producing deacetylcephalosporin C was constructed by transforming a cephalosporin C esterase gene from Rhodosporidium toruloides into Acremonium chrysogenum. The cephalosporin C esterase gene can be expressed from its endogenous R. toruloides promoter or from the Aspergillus nidulans trpC promoter under standard Acremonium chrysogenum fermentation conditions. The expression of an active cephalosporin C esterase enzyme in A. chrysogenum results in the conversion of cephalosporin C to deacetylcephalosporin C in vivo, a novel fermentation process for the production of deacetylcephalosporin C. The stability of deacetylcephalosporin C in the fermentation broth results in a 40% increase in the cephalosporin nucleus.


Archive | 1998

High expression Escherichia coli expression vector

Suo W. Liu; Thomas Franceschini


Archive | 2006

Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof

Nigel Ian Bowers; Paul M. Skonezny; Gregory L. Stein; Thomas Franceschini; Shu-Jen Chiang; Wendy L. Anderson; Li You; Zizhuo Xing


Archive | 2010

Genetically Stable Plasmid Expressing PDH and FDH Enzymes

Jonathan D. Basch; Thomas Franceschini; Suo Win Liu; Shu-Jen Chiang


Archive | 2004

Process for preparing dideoxyinosine using adenosine deaminase enzyme

Paul M. Skonezny; Michael Politino; Suo W. Liu; Alfred W. Boyle; Jason G. Chen; Gregory L. Stein; Thomas Franceschini; Wendy L. Anderson


Archive | 1998

D-amino acid oxidase promoter from T. variabilis

Suo W. Liu; Thomas Franceschini


Archive | 2009

Rhodococcus erythropolis strain

Nigel Ian Bowers; Paul M. Skonezny; Gregory L. Stein; Thomas Franceschini; Shu-Jen Chiang; Wendy L. Anderson; Li You; Zizhuo Xing


Archive | 2006

A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF

Nigel Ian Bowers; Paul M. Skonezny; Gregory L. Stein; Thomas Franceschini; Shu-Jen Chiang; Wendy L. Anderson; Li You; Zizhuo Xing


Archive | 2010

Plasmide génétiquement stable exprimant les enzymes pdh et fdh

Jonathan D. Basch; Thomas Franceschini; Suo Win Liu; Shu-Jen Chiang


Archive | 2006

Preparation process (2R, 3S) -1,2-epoxy-3- (protected) amino-4-substituted butane and intermediates thereof.

Wendy L. Anderson; Nigel Ian Bowers; Shu-Jen Chiang; Thomas Franceschini; Paul M. Skonezny; Gregory L. Stein; Zizhuo Xing; Li You

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Li You

Bristol-Myers Squibb

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