Thomas Franceschini
Bristol-Myers Squibb
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Publication
Featured researches published by Thomas Franceschini.
Journal of Industrial Microbiology & Biotechnology | 2004
Jonathan D. Basch; Thomas Franceschini; Sean M. Tonzi; Shu-Jen Chiang
A recombinant fungal microorganism capable of producing deacetylcephalosporin C was constructed by transforming a cephalosporin C esterase gene from Rhodosporidium toruloides into Acremonium chrysogenum. The cephalosporin C esterase gene can be expressed from its endogenous R. toruloides promoter or from the Aspergillus nidulans trpC promoter under standard Acremonium chrysogenum fermentation conditions. The expression of an active cephalosporin C esterase enzyme in A. chrysogenum results in the conversion of cephalosporin C to deacetylcephalosporin C in vivo, a novel fermentation process for the production of deacetylcephalosporin C. The stability of deacetylcephalosporin C in the fermentation broth results in a 40% increase in the cephalosporin nucleus.
Archive | 1998
Suo W. Liu; Thomas Franceschini
Archive | 2006
Nigel Ian Bowers; Paul M. Skonezny; Gregory L. Stein; Thomas Franceschini; Shu-Jen Chiang; Wendy L. Anderson; Li You; Zizhuo Xing
Archive | 2010
Jonathan D. Basch; Thomas Franceschini; Suo Win Liu; Shu-Jen Chiang
Archive | 2004
Paul M. Skonezny; Michael Politino; Suo W. Liu; Alfred W. Boyle; Jason G. Chen; Gregory L. Stein; Thomas Franceschini; Wendy L. Anderson
Archive | 1998
Suo W. Liu; Thomas Franceschini
Archive | 2009
Nigel Ian Bowers; Paul M. Skonezny; Gregory L. Stein; Thomas Franceschini; Shu-Jen Chiang; Wendy L. Anderson; Li You; Zizhuo Xing
Archive | 2006
Nigel Ian Bowers; Paul M. Skonezny; Gregory L. Stein; Thomas Franceschini; Shu-Jen Chiang; Wendy L. Anderson; Li You; Zizhuo Xing
Archive | 2010
Jonathan D. Basch; Thomas Franceschini; Suo Win Liu; Shu-Jen Chiang
Archive | 2006
Wendy L. Anderson; Nigel Ian Bowers; Shu-Jen Chiang; Thomas Franceschini; Paul M. Skonezny; Gregory L. Stein; Zizhuo Xing; Li You