Paula Gomes

Cytogenetic findings in eleven gastric carcinomas

We describe the results of the cytogenetic study of 10 primary adenocarcinomas of the stomach and one lymph node metastasis of a gastric adenocarcinoma after direct harvesting or short-term in vitro culture. All cases showed a variable number of numerical and/or structural clonal cytogenetic aberrations. Polysomy of chromosomes 2 and 20 were the most common numerical abnormalities. Rearrangements of chromosomes 1, 3, 7, and 13 were each observed in more than half the cases. Chromosomes 3 and 13 were the chromosomes more often exhibiting structural cytogenetic aberrations. In five tumors, rearrangements of chromosome 6 resulting in partial deletion of 6q were noted (common deleted region 6q21-22-->qter). The recurrent markers observed in our series were an i(8q) and an i(17q) in three and two cases, respectively. Double minutes (dmin) or homogeneously staining regions (hsr) were evident in three tumors. Contrary to the recent claim that structural abnormalities affecting 11p13-p15 were specifically involved in gastric cancer, we detected rearrangements of this region in only two cases.

Cytogenetic findings in 18 follicular thyroid adenomas

Cytogenetic study of 18 follicular thyroid adenomas showed clonal chromosome changes in 12 tumors. These results suggest the existence of at least three cytogenetically distinct subgroups: a hyperploid group characterized by the presence of a cluster of numerical changes including +5, +7, and +12 as the most frequent anomalies and, less frequently, +4, +9, +14, +16, and +17; a pseudo- or near-diploid group characterized by simple karyotypic aberrations; and a cytogenetically normal group.