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Dive into the research topics where Pedro Ojeda is active.

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Featured researches published by Pedro Ojeda.


The Journal of Allergy and Clinical Immunology | 2013

Validation of the first treatment-specific questionnaire for the assessment of patient satisfaction with allergen-specific immunotherapy in allergic patients: the ESPIA questionnaire.

José L Justicia; Victoria Cardona; Pedro Guardia; Pedro Ojeda; Jm Olaguibel; J. M. Vega; Carmen Vidal; Eva Eva Baró; Mario Alberto García

BACKGROUND Satisfaction with treatment is a patient-reported outcome shown to be associated with the patients health-related decisions and treatment-related behavior, thereby influencing the chances of successful treatment, and is especially relevant in long-term treatment, such as allergen-specific immunotherapy (AIT). OBJECTIVE We sought to assess the psychometric properties of the Satisfaction Scale for Patients Receiving Allergen Immunotherapy (ESPIA) questionnaire so as to determine the satisfaction of patients receiving AIT treatment. METHODS An observational, longitudinal, multicenter study was performed on patients with allergic rhinitis (AR) undergoing AIT treatment. Sociodemographic, clinical, and patient-centered health outcomes data were gathered at the study visits. Feasibility, reliability, validity, and sensitivity to change of the prevalidated version of the ESPIA questionnaire were assessed. RESULTS Four hundred twenty-nine patients were included (52.2% women, 33.6 years of age, 54.5% of the cases with intermittent AR and 62.5% with moderate AR). Low levels of missing items and ceiling/floor effects were found for the overall score of the ESPIA questionnaire. The overall Cronbach α value and intraclass correlation coefficient were 0.90 and 0.92, respectively. The overall score for the ESPIA questionnaire was strongly associated with months receiving AIT, AR type and intensity, presence of conjunctivitis, self-perceived health status, effect of AR on daily life, and expectations about the AIT treatment. The pattern of correlations obtained with other patient-centered health outcomes was consistent with expectations. The ESPIA questionnaire also showed good sensitivity to change for improved health status. CONCLUSION The ESPIA questionnaire to assess patient satisfaction with respect to AIT treatment presented satisfactory psychometric properties for its use in clinical practice.


The Journal of Allergy and Clinical Immunology | 2013

Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs.

Carmen Vidal; Liliana Porras-Hurtado; Raquel Cruz; Joaquín Quiralte; Victoria Cardona; C. Colás; Luisa F. Castillo; Carmen Marcos; Teresa Soto; Raquel Lopez-Abad; Dolores Hernández; Maria Teresa Audicana; Margarita Armisén; Virginia Rodríguez; Celsa Pérez-Carral; Esther Moreno; Rosario Cabañes; Mercè Corominas; Antonio Parra; Teófilo Lobera; Dolores Quiñones; Pedro Ojeda; Ildefonso Luna; Maria J. Torres; Angel Carracedo

8. Martin L, Raison-Peyron N, N€othen MM, Cichon S, Drouet C. Hereditary angioedema with normal C1 inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in the F12 gene. J Allergy Clin Immunol 2007;120:975-7. 9. Kluft C. Determination of prekallikrein in human plasma: optimal conditions for activating prekallikrein. J Lab Clin Med 1978;91:83-95. 10. Drouet C, D esormeaux A, Robillard J, Ponard D, Bouillet L, Martin L, et al. Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P. J Allergy Clin Immunol 2008;121:429-33. 11. Duan QL, Binkley K, Rouleau GA. Genetic analysis of factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema. J Allergy Clin Immunol 2009;123:906-10.


Allergy, Asthma & Clinical Immunology | 2013

A topical microemulsion for the prevention of allergic rhinitis symptoms: results of a randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial (Nares study)

Pedro Ojeda; Núria Piqué; Alicia Alonso; Julio Delgado; Francisco Feo; Juan Manuel Igea; Ana Navarro; Jm Olaguibel; Javier Subiza; Carles Nieto; Morgan Andersson

BackgroundSince barrier protection measures to avoid contact with allergens are being increasingly developed, we assessed the clinical efficacy and tolerability of a topical nasal microemulsion made of glycerol esters in patients with allergic rhinitis.MethodsRandomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial in which adult patients with allergic rhinitis or rhinoconjunctivitis due to sensitization to birch, grass or olive tree pollens received treatment with topical microemulsion or placebo during the pollen seasons. Efficacy variables included scores in the mini-RQLQ questionnaire, number and severity of nasal, ocular and lung signs and symptoms, need for symptomatic medications and patients’ satisfaction with treatment. Adverse events were also recorded.ResultsDemographic characteristics were homogeneous between groups and mini-RQLQ scores did not differ significantly at baseline (visit 1). From symptoms recorded in the diary cards, the ME group showed statistically significant better scores for nasal congestion (0.72 vs. 1.01; p = 0.017) and mean total nasal symptoms (0.7 vs. 0.9; p = 0.045). At visit 2 (pollen season), lower values were observed in the mini-RQLQ in the ME group, although there were no statistically significant differences between groups in both full analysis set (FAS) and patients completing treatment (PPS) populations. The results obtained in the nasal symptoms domain of the mini-RQLQ at visit 2 showed the highest difference (−0.43; 95% CI: -0.88 to 0.02) for the ME group in the FAS population. The topical microemulsion was safe and well tolerated and no major discomforts were observed. Satisfaction rating with the treatment was similar between the groups.ConclusionsThe topical application of the microemulsion is a feasible and safe therapy in the prevention of allergic symptoms, particularly nasal congestion.Trial registrationClinicalTrials.gov Identifier: NCT01478425


Current Medical Research and Opinion | 2014

Barrier-enforcing measures as treatment principle in allergic rhinitis: a systematic review

Morgan Andersson; Lennart Greiff; Pedro Ojeda; Per Wollmer

Abstract Background and objectives Barrier-enforcing measures have been suggested as treatment options for allergic rhinitis. This review identifies and describes the literature on the subject. Methods Relevant publications were searched for in the PubMed database (search entries: ‘allergic rhinitis’ and ‘treatment’). The evaluation comprised condition (seasonal or perennial allergic rhinitis), type of intervention, duration of treatment, study design, peer review status or not, number of test subjects, type of allergen exposure, and outcome in terms of effects or not on nasal symptoms of allergic rhinitis. Results Fifteen studies were either identified in the PubMed database search or from the reference lists of identified publications. Seven were placebo-controlled, randomized, and peer-reviewed, and symptom-reducing effects were reported by all of these reports. Limitations of this review reflect that the remainder of the studies had inferior designs, particularly lack of placebo control. Conclusions Barrier-enforcing measures as achieved by nasal administrations of cellulose powder and microemulsions, respectively, have symptom-reducing effects in allergic rhinitis.


Patient Preference and Adherence | 2011

Development of a questionnaire to assess patient satisfaction with allergen-specific immunotherapy in adults: item generation, item reduction, and preliminary validation

José L Justicia; Eva Eva Baró; Victoria Cardona; Pedro Guardia; Pedro Ojeda; Jm Olaguibel; J. M. Vega; Carmen Vidal

Background: Allergen-specific immunotherapy (SIT) is a treatment capable of modifying the natural course of allergy, so ensuring good adherence to SIT is fundamental. Up until now there has not existed an instrument specifically developed to measure patient satisfaction with SIT, although its assessment could help us to comprehend better and improve treatment adherence and effectiveness. The aim of this study was to develop an instrument to measure adult patient satisfaction with SIT. Methods: Items were generated from a literature review, focus groups with allergic adult patients undergoing SIT, and a meeting with experts. Potential items were administered to allergic patients undergoing SIT in an observational, cross-sectional, multicenter study. Item reduction was based on quantitative and qualitative criteria. A preliminary assessment of feasibility, reliability, and validity of the retained items was performed. Results: An initial pool of 70 items was administered to 257 patients undergoing SIT. Fifty-four items were eliminated resulting in a provisional instrument with 16 items. Factor analysis yielded four factors that were identified as perceived efficacy, activities and environment, cost-benefit balance, and overall satisfaction, explaining 74.8% of variance. Ceiling and floor effects were negligible for overall score. Overall score was associated with the type and intensity of symptoms. Conclusion: This is the first attempt to develop a satisfaction with SIT measure from the perspective of the allergic patient, and evidence has been found in favor of its reliability and validity.


Value in Health | 2015

Economic Evaluation Of Fluticasone Propionate/Formoterol Fumarate (Flutiform®) Vs Fluticasone/Salmeterol And Budesonide/Formoterol In Spain.

E Martínez-Moragón; Julio Delgado; Pedro Ojeda; L Pérez del Llano; C Antón; C Martín; Jm Collar

Introduction The aim of this economic evaluation was to estimate the cost-effectiveness of fluticasone propionate/formoterol (FP/FORM; Flutiform®) and compare it to those of fluticasone/salmeterol (FS) and budesonide/formoterol (BF) when used in the treatment of adult patients with moderate-to-severe asthma.


The Journal of Allergy and Clinical Immunology | 2005

IgE-mediated asthma associated with a unique allergen from Angelim pedra (Hymenolobium petraeum) wood

Enrique Alday; María Gómez; Pedro Ojeda; María Luisa Caballero; Ignacio Moneo


/data/revues/00916749/unassign/S0091674913006921/ | 2013

Association of thromboxane A1 synthase ( TBXAS1 ) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs

Carmen Vidal; Liliana Porras-Hurtado; Raquel Cruz; Joaquín Quiralte; Victoria Cardona; C. Colás; Luisa F. Castillo; Carmen Marcos; Teresa Soto; Raquel Lopez-Abad; Dolores Hernández; Maria Teresa Audicana; Margarita Armisén; Virginia Rodríguez; Celsa Pérez-Carral; Esther Moreno; Rosario Cabañes; Mercè Corominas; Antonio Parra; Teófilo Lobera; Dolores Quiñones; Pedro Ojeda; Ildefonso Luna; Maria J. Torres; Angel Carracedo


Pulmonary Therapy | 2016

Economic Evaluation of Fluticasone Propionate/ Formoterol (Flutiform ) vs. Fluticasone/Salmeterol and Budesonide/Formoterol in Spain.

Eva Martínez Moragón; Julio Delgado; Pedro Ojeda; Luis Pérez del Llano; Juan Manuel Collar; Cristina Antón-Rodriguez; Carlos Martín-Saborido


Prevención, trabajo y salud: Revista del Instituto Nacional de Seguridad e Higiene en el Trabajo | 1999

Alerta preventiva en el mundo laboral: alergia a enzimas, una consecuencia del uso industrial de alergenos

María Gómez; Alfredo Botello; Pedro Ojeda; Enrique Alday Figueroa; Ignacio Moneo

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Carmen Vidal

University of Santiago de Compostela

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Victoria Cardona

Autonomous University of Barcelona

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Angel Carracedo

University of Santiago de Compostela

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Carmen Marcos

University Hospital Complex Of Vigo

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Joaquín Quiralte

University of Las Palmas de Gran Canaria

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Liliana Porras-Hurtado

University of Santiago de Compostela

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Maria J. Torres

Spanish National Research Council

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Raquel Cruz

University of Santiago de Compostela

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