Perumal Rajakumar

Synthesis of novel carbazole based macrocyclic amides as potential antimicrobial agents

A series of carbazole based macrocyclic diamides with thia and oxy linkages have been synthesized and the inhibitory activity of the cyclophane amides against human pathogenic bacteria and plant pathogenic fungi are documented. (S)-1,10-Bi-2-naphthol [(S)-BINOL] based chiral carbazolophane amide emerged as the most interesting compound in this series exhibiting excellent antibacterial and antifungal activities.

Synthesis and In-vitro anti-inflammatory activity of novel glycodendrimers with benzene 1,3,5 carboxamide core and triazole as branching unit

Novel glycodendrimers scaffolds containing twelve and eighteen α-D-glycopyranoside at the periphery and triazole as branching unit have been synthesized using click chemistry. Higher generation dendrimers exhibit better anti-inflammatory activity than the lower generation due to the presence of more triazole branching units and multivalent glycopyranoside units.

Influence of triazole dendritic additives in electrolytes on dye-sensitized solar cell (DSSC) performance

Novel triazole dendritic molecules bearing dimethyl isophthalate surface group are synthesized. The enhancement of triazole and carboxylate groups in the dendritic structures significantly alter the absorption, electrochemical and DSSCs behaviors. With dendritic additive DSSCs cell exhibited higher Voc values and power conversion efficiency (η) in I−/I3−redox couple under simulated AM 1.5 at 40 mW cm−2.

Synthesis of bicyclic cyclophanes with chiral cages by sixfold coupling

Coupling of (S)-binol with various tribromides afforded bicyclic cyclophanes by six fold coupling. Coupling of tricarbonyl tribromide with binol gave a novel chiral cyclophane with six co-ordination sites for complexation.

Synthesis of chiral cyclophanes based on meta-terphenyl and pyridyl blocks

Abstract Coupling of m-terphenyl dibromide with binol afforded the corresponding optically active cyclophane. Chiral cyclophanes were also obtained by the coupling of p-nitrophenol or 4,4″-bis(bromomethyl)-1,3-dibenzylbenzene with binol.

Synthesis of some novel imidazole-based dicationic carbazolophanes as potential antibacterials

Synthesis of fluorescent imidazole-based dicationic carbazolophanes incorporating various spacer units is described. Interestingly, the cyclophanes 2a and 5a incorporating a pyridine moiety exhibited superior antibacterial activity against most of the pathogenic bacteria in the tested concentrations as compared to the other cyclophanes as well as the test control, benzalkonium chloride (BAC), cetylpyridinium chloride (CPC) and tetracycline.

Benzotriazolophanes—New Class of Novel Cyclophanes

Abstract Alkylation of benzotriazole with various xylenyl dibromides (o, m, p) or 4,4′-bis(bromethyl)biphenyl in two steps afforded the benzotriazolophanes 2 or 3. Similarly alkylation of benzotriazole with 4,4″-bis(bromomethyl)-1,1′:3′,1″-terphenyl in two steps gave the unprecedented benzotriazolophane 4a. By similar alkylation procedure, cyclophanes 4b, 4c and 4d were obtained from the substituted dibromides 6b, 6c and 6d, respectively. Novel cross-linked benzotriazolophane 5 was obtained by using the tetrabromide 9 as the spacer unit.

TiCl4, Dioxane—A Facile and Efficient System for De-O-Benzylation, De-O-Allylation, and De-O-Xylylation of Phenolic Ethers

Abstract Simultaneous de-O-xylylation and reductive coupling was observed when 1 equiv. of the dialdehyde 2a/2b was treated with 5 equiv. of each TiCl4 and Zinc which lead to the development of TiCl4 in dioxane as a new system for the facile deprotection of phenolic ethers 4a–4d, 5a–5d, and 6a–6c.

Synthesis of triazole dendrimers with a dimethyl isophthalate surface group and their application to dye-sensitized solar cells

Dendritic architectures with 1,2,3-triazole as the building unit and dimethyl isophthalate as the surface group are synthesized through a convergent approach employing click chemistry and tested for their application in dye-sensitized solar cells (DSSCs). The studies revealed that the presence of triazole and isophthalate groups in dendritic structures significantly altered the absorption, electrochemical and DSSC behaviors. In DSSCs, the dendritic structures exhibited higher Voc values and higher power conversion efficiency (η) in the I−/I3− redox couple under simulated conditions at 40 mW cm−2.

Synthesis and antioxidant properties of enone core based dendrimers with carbazole as surface group.

Synthesis of enone core based dendrimers with carbazole as surface group has been achieved. All the synthesized dendrimers showed excellent antioxidant behavior with commercially available 1,1-diphenyl-2-picryl hydrazyl (DPPH).