Ayyavoo Kannan

1,2,3-Triazole Ferrocenyldendrimers Through Click Chemistry Approach and their Optical and Electrochemical Properties

Novel ferrocenyl dendrimers with ferrocene as a surface group and with triazole as a bridging unit have been synthesised through click chemistry. The increasing numbers of triazole and ferrocenyl units at the antenna increase the light absorbing ability. The electrochemical behaviour changes with increasing ferrocenyl and triazole units.

Investigation of Optical Spectroscopic and Computational Binding Mode of Bovine Serum Albumin with 1, 4-Bis ((4-((4-Heptylpiperazin-1-yl) Methyl)-1H-1, 2, 3-Triazol-1-yl) Methyl) Benzene.

A newly synthesized 1, 4‐bis ((4‐((4‐heptylpiperazin‐1‐yl) methyl)‐1H‐1, 2, 3‐triazol‐1‐yl) methyl) benzene from the family of piperazine derivative has good anticancer activity, antibacterial and low toxic nature; its binding characteristics are therefore of huge interest for understanding pharmacokinetic mechanism of the drug. The binding of piperazine derivative to bovine serum albumin (BSA) was investigated using fluorescence spectroscopy. The molecular distance r between the donor (BSA) and acceptor (piperazine derivative) was estimated according to Forsters theory of nonradiative energy transfer. The physicochemical properties of piperazine derivative, which induced structural changes in BSA, have been studied by circular dichroism and those chemical environmental changes were probed using Raman spectroscopic analysis. Further, the binding dynamics was expounded by synchronous fluorescence spectroscopy and molecular modeling studies explored the hydrophobic interaction and hydrogen bonding results, which stabilize the interaction.

Synthesis, photophysical and electrochemical properties of 1,2,3-triazolyl bridged ferrocenyl dendrimers through click chemistry

Triazole-based novel dendrimers with ferrocenyl surface groups have been achieved through click chemistry, both by divergent and convergent approaches. The presence of more ferrocenyl and triazolyl units in dendrimers 1–4 alters the current potential curve in the voltammogram and also the absorption coefficient in the UV-vis spectrum.

Synthesis and catalytic application of glycodendrimers decorated with gold nanoparticles – reduction of 4-nitrophenol

Gold nanoparticle decorated glycodendrimers 1, 2, 3 and 4 were synthesized using a click chemistry approach. Gold nanoparticles (NPs) were synthesized in good yields either by stabilization or encapsulation of the triazolyl glycodendrimers. Gold nanoparticles were stabilized (DSNPs) by the zeroth generation dendrimer and encapsulated (DENPs) by the first generation glycodendrimer. The Au–DSNPs and Au–DENPs were characterized using UV-Vis spectroscopy and high resolution transmission electron microscopy (HRTEM) which shows that Au–DSNPs and Au–DENPs have an average of diameter 7.2 nm and 4.0 nm, respectively. The catalytic activity of Au–DSNPs for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) with NaBH4 in aqueous conditions was examined using UV-Vis spectroscopy.

Synthesis, characterization, optical and electrochemical properties and antifungal and anticancer activities of ferrocenyl conjugated novel dendrimers

A new class of triazoloferrocenyl conjugates (1, 2 and 3) was obtained by copper(I) catalyzed click chemistry, specifically the alkyne azide cycloaddition (CuAAC) of bis(β-hydroxyl)arylalkyneether with suitable ferrocenyl azides. The synthesized bis(β-hydroxyl)arylether linked ferrocenyl conjugates 1, 2 and 3 exhibit antifungal activity against fungal pathogens, viz. Candida albicans, Candida glabrata and Candida crusi, comparable to that of amphotericin B and also show excellent anticancer activity against MCF-7 cell lines.

Synthesis and Anti-Inflammatory Activity of Triazole Based Macrocyclic Amides through Click Chemistry

ABSTRACT Triazole-based macrocyclic amides 1–12 with amide group as the intrannular functionality has been synthesized through click chemistry. Triazole-based macrocyclic amides 1–12 show good anti-inflammatory activity even at low concentration (50 µg/mL) when compared to that of the reference drug prednisolone. BINOL-based chiral macrocyclic amides and pyridine-based macrocyclic amides show better anti-inflammatory activity than the other synthesized macrocyclic amides. GRAPHICAL ABSTRACT

Synthesis and in vitro anti-arthritic, anti-inflammatory studies on hypervalent pyranoside glycodendrimers with triazole bridging point

Synthesis of novel glycodendrimer scaffolds containing hypervalent sugar pyranosides and triazole bridging points is described. Dendrimers with a greater number of bridging triazole units and α-d-glycopyranosyl surface groups exhibit better anti-arthritic and anti-inflammatory activity than dendrimers with less number of triazole and α-d-glycopyranosyl units.

Synthesis, photophysical and electrochemical properties of a new class of fluorescent amidoanthracenophanes

Fluorescent amidoanthracenophanes 1, 2, 3 and 4 were obtained from the various aromatic diacid chlorides and diamino precyclophane by simple acylation. All the synthesized amidoanthracenophanes 1, 2, 3 and 4 show three intense fluorescence bands between 401 and 402, 426 and 429, and at 449 to 451 nm, and exhibit two/three oxidation reduction peaks in the cyclic voltammetry which is characteristic of fluorophoric anthracene units.

Synthesis, photophysical, electrochemical and laser properties of anthracene conjugated glycodendrimers with triazole as a bridging unit

Anthracene conjugated blue light emitting glycodendrimers 1, 2 and 3 were synthesized using Cu(I) catalyzed click chemistry. All of the anthracene conjugated blue light emitting glycodendrimers have enhanced photophysical, electrochemical and laser properties, from the lower to the higher generation dendrimers. Blue light emitting higher generation glycodendrimer 3 shows a longer life time (11.2 ns) than the lower generation glycodendrimers 1 and 2 due to the presence of a larger number of triazole bridging units and multivalent glucose units.