Povi Lawson-Evi

Antioxidant effects of Ixora coccinea Linn. in a rat model of ovalbumin-induced asthma

Oxidative stress, specifically lipid peroxidation, contributes to the pathogenesis of asthma. A natural antioxidant could be a potential therapeutic intervention. Hydro-alcoholic extract of Ixora coccinea (ICE) exhibit the anti-asthmatic activity in an ovalbumin (OVA) induced asthmatic rat model. These facts led us to examine their antioxidant activities. The free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and the intracellularly antioxidant activity of ICE were determined. The protective effect of ICE against 2,2′ azobis (2-amidinopropane) hydrochloride (AAPH)-induced red blood cell lysis was also evaluated. It was found that ICE could scavenge DPPH with an IC50 of 283.3 µg/ml and protected red blood cell against AAPH-induced hemolysis with an IC50 of 72.92 versus 52.08 µg/ml for ascorbic acid. Erythrocytes obtained from the ICE-administrated rats showed an enhanced resistance to hemolysis. In OVA-induced asthma, rats were sensitized and challenged with ovalbumin. The effect of ICE at 1500 mg/kg per os on malondialdehyde (MDA) production and lung catalase activity were determined. ICE significantly reduced the lipid peroxidation and enhanced catalase activity in lung (p < 0.05). In conclusion, the hydro-alcoholic extract of I. coccinea possesses an antioxidant activity and protective effect against free-radical-induced hemolysis. This may explain the traditional use of this plant as a remedy against asthma and other diseases.

Effect of Topical Application of Hydro-Ethanolic Extract of Acacia nilotica Pods on Second-Degree Cutaneous Infected Burns

Acacia nilotica is a medicinal plant used traditionally in Togo to treat various diseases including burn wounds. The aim of this study was to evaluate experimentally Acacia nilotica burn wound healing effect. Cutaneous burn wounds were symmetrically caused on depilated areas of rat skin through contact with an aluminum bar (r = 10 mm), preheated at 80°C for 30 sec. Five groups of animal were constituted and each group contained 8 mice. Four groups of animal’s burn wounds were infected by Staphylococcus aureus . One group burn wound is uninfected and serves as negative control. Burn wounds were assessed by planimetry and histological parameters of healing. Twelve days after burn wound induction, wound contraction in the uninfected groups (negative control) was 19.9% for topical application against -2.43% for infected control. In the infected groups treated with extract, wound contraction was generally stimulates. Histological examination showed granulated tissue developing over the wounds treated with the extract of A. nilotica at 2.5% and 5% where the proliferation of fibroblasts and neo-blood vessels was very marked. In conclusion, A. nilotica pod contents tannin, flavonoids, alkaloids and protein reduces DPPH solution and significantly accelerates wound healing of burns, and this is the case even if wounds are infected with 10 9 CFU/mL of S. aureus .

EFFET TOPIQUE DE L’EXTRAIT HYDROETHANOLIQUE DE L’ACACIA NILOTICA SUR LA CICATRISATION CUTANEE DES BRULURES DE SECOND DEGRE

This research theme is the impact of the proactive transfer of motor learning between handball and basketball; carry out of the first year of secondary school pupils (15-17 years) of high school IdrisSenouci of Mostaganem city (Algeria). This study aimed to show the existence of a reciprocal proactive transfer of motor learning in the subsequent practice between handball and basketball in the direction of basketball to handball. For this, I hypothesized that there is a reciprocal proactive transfer motor learning engine between handball and basketball in favour of the sense of basketball to handball. To realize this study, I selected a systematic sample of 184 pupils’ boys and girls representing 36.44% of the population retort on four groups, two experimental and two controls to compare their results. And in order to measure the impact of reciprocal proactive transfer of motor learning between handball and basketball, I have conceived an experience based on the experimental protocol of Schmidt (1975) which compares between the performances of an experimental group to those of the control group. Thus, and after analyzing the results of the experiment, it is proved that the proactive transfer of motor learning was embodied in the sense of basketball to handball depending on three statistical means that are the T Students, the percentage of development, and the transfer index of Murdock.