R. B. Mane

Borohydride reducing agent derived from anion exchange resin: selective reduction of α, β-unsaturated carbonyl compounds.

Abstract Borohydride exchange resin (BER) exhibited selectivity in the reduction of α, β-unsaturated carbonyl compounds to the corresponding unsaturated alcohols.

A SIMPLE AND PRACTICAL HALOGENATION OF ACTIVATED ARENES USING POTASSIUM HALIDE AND OXONE® IN WATER-ACETONITRILE MEDIUM

A simple and practical halogenation of activated arenes using a reagent combination of potassium halide and oxone® in water-acetonitrile medium is presented. The halogenated products were obtained with good yields and in high purity.

One Pot Synthesis of Monoalkylated and Mixed, Dialkylated Meldrum's Acid Derivatives

Abstract A simple one pot method, involving sequential Knoevenagel condensation of Meldrums acid with aromatic aldehydes, conjugate reduction of ylidene Meldrums acid using sodium borohydride followed by alkylation, to prepare mixed dialkylated derivatives of Meldrums acid is described.

Heck reaction in aqueous medium using Amberlite IRA-400 (basic)Dedicated to the memory of the Late Dr Nitiraj R. Mane.

Efficient Heck reaction in aqueous medium using Amberlite IRA-400 (basic) as a base is reported.

Syntheses and properties of oligothymidylate analogs containing stereoregulated phosphorothioate and phosphodiester linkages in an alternating manner

Abstract Syntheses of decadeoxythymidylates containing stereoregulated phosphorothioate and phosphodiester linkages in an alternating manner starting from preseparated diastereochemically pure phosphorothioate dimers are described. Hybridization of these modified oligonucleotides with the complementary sequence has been investigated.

Potassium phosphate catalyzed nitroaldol reaction

Abstract Potassium phosphate was found to catalyze condensation of nitroalkanes with various aliphatic and aromatic aldehydes to form nitroaldols in excellent yields in acetonitrile medium at room temperature.

A novel short synthesis of norbisabolide

A novel two-step synthesis of norbisabolide is reported involving free radical addition of Meldrums acid to (R)-(+)-limonene using cerium(IV) ammonium nitrate (CAN) followed by decarboxylation with poly-4-vinylpyridine.

A simple and efficient oxidation of hydrazides to N,N‘-diacylhydrazines using Oxone® in an aqueous medium

Substituted aromatic hydrazides have been oxidised to N,N′-diacylhydrazines in high yields using Oxone in an aqueous medium at room temperature.

Synthesis of deuterium labelled acids

Knoevenagel condensation of Meldrums acid (1) with benzaldehyde, anisaldehyde, furfural, cinnamaldehyde and acetone gave the corresponding alkylidene derivatives (3) which were reduced with sodium borohydride to yield alkyl Meldrums acids (4). Reaction of (4) with pyridine-D2O at high temperature furnished α-dideuterated acids (6). The reduction of alkylidene derivatives (3) with sodium borodeuteride yielded β-deuterated alkyl Meldrums acids (7) which on hydrolysis and decarboxylation yielded β-deuterated acids (9). α,α,β-Trideuterated acids (11) were prepared by hydrolysis and decarboxylation of (7) with pyridine-D2O. Copyright

Demethylation of Methyl Aryl Ethers using Pyridine Hydrochloride in Solvent-free Conditions under Microwave Irradiation

Methyl aryl ethers are deprotected in high yields using pyridine hydrochloride in the absence of solvent under microwave irradiation.