R. Drew Miller

Thrombo-embolism in Acute and in Healed Myocardial Infarction I. Intracardiac Mural Thrombosis

This is a study of the location and incidence of intracardiac thrombi in acute and in healed myocardial infarction. In myocardial infarction intracardiac thrombi occur predominantly in the left ventricle. Anterior myocardial infarcts are more commonly associated with mural thrombi than posterior myocardial infarcts. Large myocardial infarcts and congestive failure are factors which predispose to the formation of left ventricular mural thrombi in myocardial infarction.

EXERTIONAL DYSPNEA: A PRIMARY COMPLAINT IN UNUSUAL CASES OF PROGRESSIVE MUSCULAR ATROPHY AND AMYOTROPHIC LATERAL SCLEROSIS

Excerpt Dyspnea is a symptom usually referable to disorders of the heart or lungs. Despite this frequent association, it is generally known that abnormalities of other systems may lead to respirato...

Management of diffuse obstructive pulmonary emphysema.

The management of degenerative diseases has become a problem of increasing magnitude to practicing physicians. This problem arises in part as a consequence of more successful control of acute diseases. Diffuse obstructive pulmonary emphysema may well be classified in the group of so-called degenerative diseases. Although the chronic form may occur in patients of almost any age, it is primarily a disease of men in and beyond the fifth decade of life. Why this condition occurs chiefly in middle-aged and elderly men is not known, and exact knowledge of its pathogenesis is limited. Because of the incomplete understanding of this process and its chronic progressive nature, therapeutic management has posed a serious problem. The occurrence of chronic or recurrent respiratory affections, such as tuberculosis, certain types of pneumoconiosis and nonspecific bronchitis, is thought to be related to an increased incidence of pulmonary emphysema. The successful treatment of tuberculosis and other specific bronchopulmonary infections may lead to survival of patients who will likely be predisposed to a greater incidence of pulmonary emphysema in the future. The increasing average age of the general population gives another indication that there are now greater numbers of persons in the age groups in which pulmonary emphysema is a common problem. Only further basic and clinical investigation will lead to more successful management of patients who have pulmonary emphysema. However, for the present, the clinician is faced with the problem of treating patients who have pulmonary insufficiency in the light of current knowledge.