R. Satheesh Babu

Highly regioselective ring opening of epoxides and aziridines using cerium(III) chloride

A wide variety of epoxides and aziridines were converted to the corresponding β-halohydrins and β-haloamines using cerium(III) chloride and the cerium(III) chloride/NaI system in acetonitrile. The reactions were highly regioselective and efficient with excellent yields under mild and neutral reaction conditions.

Stereoselective total synthesis of (+)-artemisinin ☆ ☆☆

The total synthesis of the novel antimalarial drug, a sesquiterpene endoperoxide, (+)-artemisinin is described. The approach is flexible and stereoselective. The use of an intermolecular radical reaction on an intermediate iodolactone and a Wittig reaction on a ketone were employed for the synthesis.

Microwave Assisted FriedläNder Condensation Catalyzed by Clay

Clay catalyzed Friedlander condensation of 2-amino arylaldehyde or ketone with carbonyl compounds containing α-methylene group has been achieved in solvent free condition under microwave irradiation to give polycyclic quinoline derivatives.

One pot synthesis of 4-(2-hydroxybenzoyl)-pyrazoles from 3-formylchromones under microwave irradiation in solvent free conditions

The synthesis of 4-(-2-hydroxybenzoyl)pyrazoles (3) was achieved in a single step by the reaction of 3-formylchromones (1) with Phenylhydrazine or Tosylhydrazine under microwave irradiation without a solvent.

A Novel, Efficient, and Selective Cleavage of Alkyltert‐Butyldimethylsilyl Ethers Using the BiCl3/NaI System

Keywords: alcohols; bismuth(III) chloride; chemoselectivity; deprotection; protecting groups; TBDMS ethers