Randhir S. Kapil

Roseoside-A C13 glycoside from Vinca Rosea

Abstract Roseoside, a C13 glycoside isolated from Vinca rosea has been assigned the structure and stereochemistry (1).

Monoterpenoid furanocoumarin lactones from clausena anisata

Abstract A reinvestigation of Clausena anisata has yielded imperatorin, xanthotoxol, lansamide-I and three new furanocoumarin lactone derivatives: indicolactone, anisolactone and 2′,3′-epoxyanisolactone. The structures of these compounds have been elucidated by a combination of spectroscopic and chemical methods.

Cordioside, a clerodane furano diterpene glucoside from Tinospora cordifolia

Abstract The structure of cordioside isolated from the stem of Tinospora cordifolia was characterized on the basis of NMR spectroscopy.

Bacteriostatic heterocycles from Euodia lunu-ankenda☆

Abstract A new constituent characterized as 8-acetyl-3,4-dihydroxy-5,7-dimethoxy-2,2-dimethylchroman has been isolated together with alloevodionol-7-methyl ether, 4-methoxy-1-methyl-2(1H)quinolinone, evolitrine, isoevodionol and its methyl ether from the aerial parts of Euodia lunu-ankenda. Its structure was confirmed by its transformation to alloevodionol-7-methyl ether. 4-Methoxy-1-methyl-2(1H)quinolinone and its isomer were synthesized by a modified procedure.

Clerodane diterpenoids from Tinospora cordifolia

Abstract Tinosponone and tinocordioside have been isolated from the stem of Tinospora cordifolia . The structures were established by spectroscopic studies and chemical correlation.

New alkaloids from Tabernaemontana divaricata

Abstract A re-investigation of the root bark of Tabernaemontana divaricata resulted in the isolation of 18 compounds, viz. α-amyrin acetate, lupeol acetate, α-amyrin, lupeol, cycloartenol, β-sitosterol, campesterol, benzoic acid, aurantiamide acetate, coronaridine, coronaridine hydroxyindolenine ( 1 ), ibogamine, 5-hydroxy-6-oxocoronaridine ( 6 ), 5-oxocoronaridine ( 9 ), 6-oxocoronaridine ( 10 ), (±)-19-hydroxycoronaridine ( 11 ), 3-oxocoronaridine ( 12 ) and voacamine. The alkaloids 6 , 9 , 10 and 11 are new compounds, whereas cycloartenol, campesterol, ibogamine, benzoic acid, aurantiamide acetate and coronaridine hydroxyindolenine are reported from this plant for the first time.

Toddasin, a new dimeric coumarin from Toddalia asiatica.

Abstract A new dimeric coumarin, named toddasin and possessing a cyclohexene ring with a vinylic side-chain interposed between the two coumarin moieties has been isolated from the roots of Toddalia asiatica. It has been characterized as (E)-8,8′-[1″,4″-dimethyl-3″ -cyclohexen-1″,2″-ylene vinylene]-bis-[5,7-dimethoxycoumarin] (1). The proposed structure is supported by the mass fragmentation of its dihydro derivative (2).

Puetuberosanol, an epoxychalcanol from Pueraria tuberosa☆

Abstract A novel chalcane derivative, puetuberosanol has been isolated from Pueraria tuberosa and its structure was deduced as 3′-hydroxy-4′-phenoxy-α,β-epoxychalcan-α′-ol, on the basis of 2D NMR spectroscopic evidence.

A furanoeremophilane from Vitex negundo

Abstract Acetyl oleanolic acid, sitosterol and a new furanoeremophilane characterized as 3-formyl-4,5-dimethyl-8-oxo-5 H -6,7-dihydronaphtho(2,3- b )furan have been isolated from the roots of Vitex negundo .

8-hydroxydihydrochelerythrine and arnottianamide from roots of Toddalia asiatica☆

Abstract In addition to hexacosanoic acid, β-sitosterol and arnottianamide, 8-hydroxydihydrochelerythrine, a new benzophenanthridine alkaloid has been isolate