Raziye Desdicioglu

Soluble urokinase-type plasminogen activator receptor (suPAR) and interleukin-6 levels in hyperemesis gravidarum

Background: The aim was to compare serum soluble urokinase‐type plasminogen activator receptor (suPAR) levels as well as interleukin‐6 levels (IL‐6) in pregnant women with hyperemesis gravidarum (HG) and asymptomatic pregnant women. Methods: Our study population consists of voluntary first trimester‐pregnant women who applied to the outpatient clinic of the department of obstetrics and gynecology of Ankara Ataturk Training and Research Hospital. Between February and May 2016, 60 pregnant women were included in our prospective study. Serum suPAR and IL‐6 levels were evaluated with the ELISA method. Twenty‐nine pregnant women with HG and 31 asymptomatic pregnant women were included in the study. Results: Serum suPAR level in the HG group was measured as 0.36 ± 0.56 ng/ml, whereas this level in the healthy pregnant control group was measured as 0.15 ± 0.15 ng/ml (p < 0.05). The interleukin‐6 level in the HG group was 5.69 ± 2.16 pg/ml, whereas in the control group it was measured as 3.88 ± 0.28 pg/ml (p < 0.05). Conclusion: Serum suPAR and IL‐6 levels proved to be high in the HG group. It is likely that suPAR could play a role in the etiopathogenesis of hyperemesis gravidarum.

Sonographic measurement of the fetal thymus: Relationship with maternal obesity

The purpose of this study was to evaluate the influence of maternal obesity on the size of the fetal thymus.

Radiological Investigation and Clinical Evaluation of the Morphometric Development of the Forearm in Human Fetuses

Fetal period of time during which the fetus grows rapidly and the organs are formed. The prenatal and postnatal analyses of the fetal structure provide information as to fetal growth, growth retardation, gestational age and congenital malf ormations. The development of the skeletal system during the intrauterine period takes place in an orderly manner as it also does in other sy tems. It was aimed that the morphometric development of the forearm in human fetuses during the period between 20-40 gestational week s be radiologically investigated and that its clinical importance be evaluated, as well. A total of 100 fetal forearms (50 fetuses: 23 male, 27 female), the ages of which varied between 20-40 gestational weeks, without having any external pathology or anomaly were incorp orat d into the study. The fetuses were separated into groups according to weeks, trimesters and months. After the general external me asur ments of the fetuses had been performed, the mammographies and forearm radiographies of the fetuses were shot in the way that the for earms would remain in a prone position. Morphometric measurements pertaining to forearm structures were taken from the forearm radiog r phies that were shot with the help of a digital compass. Later on, the morphometric measurements in question were statistically evalu ated. The mean values and the standard deviations of the measured parameters were determined according to gestational weeks, trimesters a nd months. There was a significant correlation between the measured parameters and the gestational age (p<0.001). In the compariso n of the measured parameters between trimesters and months, it was observed that there was a statistically significant difference betwee n th groups (p<0.05). Separately, it was also determined that there was no statistically significant difference in the comparison of the parameters, which was made between genders and right-left forearms (p>0.05). As for the results obtained in our study, we are of the opinio n at the data obtained during this study period will be beneficial for the involved clinicians, such as those in charge of gynecology, r adi l , forensic medicine and perinatology, in terms of evaluating the clinical studies related to the morphometric development of the forearm throughout the fetal period, in determining the fetal age and sex, and also in determining the pathologies and variations regar ding the development of fetal skeletal system.

Impact of Bimanual Vaginal Examination on Pap Smear Test Results

Objective: The aim of the study is to evaluate the possible effects of the various conditions especially bimanual examination on the adequacy of pap smear test. Study Design: Presented here is a prospective controlled clinical trial carried out at Ankara Ataturk Training and Research Hospital between November 2013 and March 2014. Total of 1771 patients seen at the gynecology outpatient clinic were included in the study. The technique described by the American Society of Cytopathology Criteria 2000 for the preparation of the specimen was followed. Updated Bethesda system 2014 was used for reporting the results. Results: Number of subjects in smear before examination group was 1194 and in the smear after examination group was 577. Two percent (n=36 subjects) of the cervicovaginal report was inadequate. When other clinical conditions were not taken into consideration, the likelihood ratio for inadequate smear in the smear after examination group was 2.64 compared to smear before examination group (p=0,004). Conclusions: In some conditions cervicovaginal smear sampling may be carried out after bimanual vaginal examination instead of missing the chance to screen the women. However, the patients have to be informed that cervicovaginal smear result might be inadequate so that a repeat test has to be carried out.