Richard Anthony Partyka

Stereoselective synthesis of 1-β-methylcarbapenem

Stereoselective syntheses of the 1-β-methylcarbapenem intermediates 9B (R=SPh or OCH3) have been accomplished by an aldol-type stereocontrolled reaction and stereoselective catalytic hydrogenation of an olefinic ester.

Synthesis of phenoxyacetyl-N-(hydroxydioxocyclobutenyl)cycloserines

Abstract The synthesis and antibacterial activity of a potential antibiotic, phenoxyacetyl-(L)-cycloserine activated by a cyclobutenedione moiety, is described.

Synthesis and in vitro antibacterial activity of new semi-synthetic noviosylcoumarin antibiotics: chemical modification at the C-3′ ester

Abstract A synthetic procedure to introduce a variety of ester groups at the C-3′ position of the noviosylcoumarin antibiotics has been developed. Several new semi-synthetic noviosylcoumarins having unique ester groups at the C-3′ position by this method were prepared and in vitro antibacterial (anti-staphylococcal) activity was evaluated.

Synthesis of α-(S)-acylamino-N-(hydroxydioxocyclobutenyl)-β-lactams as potential antibiotics

Abstract Monocyclic β-lactams 6 activated by a hydroxycyclobutenedione moiety have been prepared as potential antibacterial agents from the natural amino acids, (L)-serine and (L)-threonine. These β-lactams were devoid of useful antibacterial activity.