Rinalda Araújo Guerra de Oliveira

Estudo da interferência de óleos essenciais sobre a atividade de alguns antibióticos usados na clínica

The aim of this study was to evaluate the interference of essential oils from Lippia sidoides Cham, Plectranthus amboinicus Lour Spr., Conyza bonariensis L. and Eucalyptus citriodora Hook on the antibacterial effect of clinically used antibiotics. The assays were carried out with ampicillin (10 µg/mL), cephalotin (30 µg/mL), chloraphenicol (30 µg/mL), gentamicin (10 µg/mL) and tetracyclin (30 µg/mL) isolated and associated with essential oils (4% v/v) by the solid medium diffusion procedure using filter paper discs. The results showed interference of some essential oils on the antibacterial activity of the assayed antibiotics. It was observed the development of growth inhibition halo with different diameters when the antibiotics were applied alone and associated with essential oils. Synergic or antagonic behavior was more prominent in interactions with S. aureus and S. epidermidis strains. On the other hand, it was observed a smaller interference of essential oils on the effect of the antibiotics against Gram negative strains, mainly P. aeruginosa. These results show that the use of plants by-products could some times interfere on the effectiveness of antibiotics used clinically.

Natural product inhibitors of ovarian neoplasia.

The present work constitutes a review of the literature on natural products with potential antitumor activity against ovarian neoplasias. The review refers to five plant extracts and sixty-nine compounds isolated from higher plants and microorganisms, which are classified in appropriate chemical groups and model tested, and cites their activity. Some aspects of recent research with natural products directed to ward producing drugs which are inhibitors of ovarian neoplasia are discussed.

Chemical and pharmacological investigation of Solanum species of Brazil: a search for solasodine and other potentially useful therapeutic agents

A systematic search for solasodine, an important starting material for the partial synthesis of steroidal hormones as well as other potentially bioactive constituents of various Solanum species of Brazil has been undertaken. Thus, the fruits of S. paludosum, S. asperum, S. sessiliflorum and Solanum sp. were found to contain significant amounts of solasodine. The root bark of S. paludosum which showed curare like activity yielded tomatidenol and another yet unidentified alkaloid responsible for the biological activity. The fruits of S. asperum yielded a new spirosolane alkaloid, solaparnaine. The stem bark of S. pseudo-quina showed convulsive and excitatory activity from which (25S)-isosolafloridine was identified as the active principle. In addition, the latter alkaloid was also found to show antimicrobial activity.

Uso de plantas medicinais pelos idosos em uma estratégia saúde da família

This study about medicinal plants was done at a Santo Antônio’s aged group in the Family’s Health Estrategy in Pedras de Fogo city — Paraíba (PB), Brasil, with the purpose to rescue the popular’s medicine traditions, valuing the acquired experiences, evaluating the risks and the benefits of its use and extending the therapeutically resources in the health primary attention with the interchange, between knowing scientific and popular creating a book of region own prescriptions. The data were collects through a questionnaire that focused questions about plants origin, way of obtaining one, cultivating one, therapeutic indications, preparation way and of using. Amongst the 50 more used plants medicinal, ten had been cited: Capim-santo (Cymbopogan citratus (DC.) Stapf.), Hortelã-da-folha-miúda (Mentha x villosa Huds), Erva-Cidreira (Lippia alba (Mill.) N.E Br,), Hortelã-da-folha-grossa (Plectranthus amboinicus Lour (Spreng)), Louro (Laurus nobilis L.), Babosa (Aloe barbadenses Mill), Colônia (Alpinia speciosa Schum), Sabugueiro (Sambucus australis Cham et Schelecht), Chachambá (Justicia pectoralis Jack) and Erva-doce (Pimpinella anisum L), which by means of consulted literature would can be part of the therapeutical armory of the Health Family Estrategies at Pedras de Fogo. Descriptors: aged; plants medicinal; knowledge.

MEDICINAL PLANTS USED IN DERMATOLOGY: BIOLOGICAL ACTIVITY EVALUATION OF ITS EXTRACTS, ESSENTIAL OILS AND ITS ASSOCIATIONS

Geral Avaliar a atividade biológica de plantas medicinais usadas nas doenças dermatológicas, utilizando-se seus extratos, alcoolaturas, óleos essenciais e suas associações com antibacterianos e antifúngicos. Específicos Fazer um estudo etnobotânico das plantas medicinais usadas nas doenças dermatológicas. Avaliar a toxicidade, dos extratos de plantas medicinais Pithecellobium cochliocarpum, Momordica charantia e Ipomoea asarifolia. Investigar a atividade antibacteriana e antifúngica de extratos, alcoolaturas e óleos essenciais. Avaliar a atividade biológica das associações entre os produtos de plantas medicinais e medicamentos antibacterianos e antifúngicos. Avaliar o grau de irritação primária de pele – efeito agudo, das alcoolaturas de Conyza bonariensis e Lippia sidoides, usadas clinicamente nos serviços de saúde para o tratamento de micoses superficiais. Investigar a atividade antitumoral de Pithecellobium cocliocarpum (Gmez) Macbr. Correlacionar o saber popular com o conhecimento científico.

USO DE REMÉDIOS CASEIROS POR MULHERES DO PROGRAMA SAÚDE DA FAMÍLIA

Exploratory descriptive study, for quantitative boarding, aiming at evaluating the use degree of twelve basic formularizations of remedies caretakers workshops with women from the Family Health Program/Woman Health, Ipes Community, at Joao Pessoa  PB. Population was constituted by women and the sample not probabilistic intentional for 104 women that answered a questionnaire elaborated with nine questions, contemplating the following variables: age, civil state, school degree and use of plants. Data had been grouped and interpreted by means of analysis descriptive statistics whose resulted they had shown that the interviewed ages had varied from 18 to 60 years, having predominated the age band between 40 and 50 years, 12,5%; as for the civil state, the union predominated consensual, 67,30%; as for school degree basic, complete education predominated; as for the basic workshops formularizations, these had been accepted for 72,11% of the sample; as for the remedy caretaker formularization, the most known was the boiled must of Plectranthus amboinicus Lour, used as bronchodilator and mucolitic 53,33% and 84,62% had thought to want to know more on medicinal plants and the illnesses treated for them. Therefore standed out that the popular participation in remedies caretakers workshops is a great value activity, since that express the bond of co-responsibility in the identification and brainstorming for the necessities in health from the experience local regional. Descriptors: Basic formularizations; Women; Family program health.