Robert James Chambers

A Stereooontrolled Approach to Tri and Tetrasubstttuted Cyclohexanones

Abstract A series of reactions utilizing acetals 2–5 with organo cuprates was studied to determine the stereoselectivity of the 1,4-conjugate addition. A90:10 stereoselectivity was observed from the reaction of lithium or bromomagnesium divinyl cuprate with acetal 5 which generated a facile entry to the tetrasubstituted cyclohexanone via a consecutive 1,4-conjugate addition - 1,3-alkylation sequence.

Leukotriene antagonists: patent highlights 1996 - 1998

Antagonists of leukotriene D4 (LTD4) have shown clinical efficacy in the treatment of asthma while efficacy with antagonists of leukotriene B4 (LTB4) has yet to be demonstrated. The development of dual mediators possessing either histamine (H1), thromboxane (TXA2), or serine protease activity coupled with leukotriene antagonist activity offers a new direction of research, one which offers the greatest potential in discovering a superior agent for the treatment of allergic and inflammatory diseases.