Rostislav Rusev

Hydrogen bonding networks in transient state of beta-lactamase protein analogous to integrated circuits

Two hydrogen bonding networks (HBN) that are extracted from the β-lactamase protein are presented and studied in the present paper. The HBNs are formed in the active site of ß-lactamase when β-lactamase is in transient state (T1). The hydrogen bonds are modeled as three or four-terminal block elements analogous to classic electrical multi-terminal networks. Each block element is coded in Matlab and described by polynomials. Block elements are then included in a microelectronic circuits analogous to “proton networks”. The dynamic and static simulations with analogous circuits are carried out in Matlab. The results showed an analogy to a current source, amplifier, current mirror, and amplitude limiter.

Microelectronic circuit emulating Hydrogen Bonding Network of Green Fluorescent Protein

Hydrogen Bonding Network in active site of wild type Green Fluorescent Protein during the A→A* state is modeled. A microelectronic equivalent circuit is developed on its basis to emulate the operational principle of the Hydrogen Bonding Network. It is coded in Matlab to investigate its static and dynamic behavior. Output characteristics of static analysis are similar to inversed tunnel diode. The dynamic analysis show that the circuit can operate as amplifier, modulator and amplitude limiter.

Circuit modeling of Green Fluorescent Protein's hydrogen bonding network in cadence

A library of block-elements that mimics the behavior of the hydrogen bonds of Green Fluorescent Protein is created in Cadence for bioelectronics applications. A circuit is designed with these elements that model the architecture and behavior of the analogous hydrogen bonding networks of the protein. The circuit is studied by DC and transient analyses. The DC analysis shows that the output voltage is a linear function of the input voltage and that the output current is a non-linear function of the output voltage. This IV-characteristic clearly shows three operating regions. Depending on the bias points the circuit inspired by the hydrogen bonding networks operates as an amplifier, modulator and amplitude limiter.

A model for reverse electrowetting with cost-effective materials

This paper, presents a model to predict the energy output from reverse electrowetting energy harvesting system with use of cost-effective materials. Reverse electrowetting on dielectric allows energy to be harvested from spontaneous aperiodic mechanical movements, where conventional energy harvesting approaches are not suitable for due to low energy conversion efficiency and frequency.

Hydrogen bonding network as a logic gate

A circuit consisting of four- and five-terminal block elements is developed to imitate the behavior of hydrogen bonding networks in the β-lactamase protein. The circuit is implemented in Cadence Spectre to simulate its signal processing capabilities. The analysis shows that circuit outputs have logic levels for the current. The simulations show that the circuit can simultaneously invert and repeat signals, i.e. parts of the protein operate as logic gates.

Investigation of power losses in synchronous buck DC-DC converter with Zero Voltage Switching

In this paper a synchronous buck dc-dc converter with Zero Voltage Switching (ZVS) for low power applications is presented and investigated in Cadence with a CMOS 0.35 μm technology. Power losses in the converters components are evaluated and analyzed. The results obtained show that the efficiency of the standard switching-mode buck dc-dc converter can be increased by about 3.6 % if ZVS technique is used.