Roy Nitulescu
Analysis Group
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Publication
Featured researches published by Roy Nitulescu.
The Journal of Clinical Psychiatry | 2005
Martin Cloutier; Myrlene Sanon Aigbogun; Annie Guerin; Roy Nitulescu; Agnihotram V. Ramanakumar; Siddhesh A. Kamat; Michael DeLucia; Ruth Duffy; Susan N. Legacy; Crystal Henderson; Clément François; Eric Q. Wu
OBJECTIVE The objective of this study was to estimate the US societal economic burden of schizophrenia and update the 2002 reported costs of
Current Medical Research and Opinion | 2014
Annie Guerin; Lei Chen; Raluca Ionescu-Ittu; Maryna Marynchenko; Roy Nitulescu; Robert Hiscock; Christopher Keir; Eric Q. Wu
62.7 billion given the disease management and health care structural changes of the last decade. METHODS A prevalence-based approach was used to assess direct health care costs, direct non-health care costs, and indirect costs associated with schizophrenia (ICD-9 codes 295.xx) for 2013, with cost adjustments where necessary. Direct health care costs were estimated using a retrospective matched cohort design using the Truven Health Analytics MarketScan Commercial Claims and Encounters, Medicare Supplemental, and Medicaid Multistate databases. Direct non-health care costs were estimated for law enforcement, homeless shelters, and research and training. Indirect costs were estimated for productivity loss from unemployment, reduced work productivity among the employed, premature mortality (ie, suicide), and caregiving. RESULTS The economic burden of schizophrenia was estimated at
Journal of Medical Economics | 2015
Annie Guerin; Medha Sasane; Jie Zhang; Kenneth W. Culver; Katherine Dea; Roy Nitulescu; Eric Q. Wu
155.7 billion (
Current Medical Research and Opinion | 2015
Annie Guerin; Medha Sasane; Heather A. Wakelee; Jack Zhang; Kenneth W. Culver; Katherine Dea; Roy Nitulescu; Philip Galebach; Alexander R. Macalalad
134.4 billion-
Journal of Medical Economics | 2016
Annie Guerin; Medha Sasane; Katherine Dea; Jack Zhang; Kenneth W. Culver; Roy Nitulescu; Eric Q. Wu; Alexander R. Macalalad
174.3 billion based on sensitivity analyses) for 2013 and included excess direct health care costs of
Journal of Medical Economics | 2017
Dominick Latremouille-Viau; Annie Guerin; Roy Nitulescu; Patrick S. Gagnon; George J. Joseph; Lei Chen
37.7 billion (24%), direct non-health care costs of
Patient Preference and Adherence | 2016
Alain Joseph; Martin Cloutier; Annie Guerin; Roy Nitulescu; Vanja Sikirica
9.3 billion (6%), and indirect costs of
Cancer Research | 2015
Christopher Gallagher; Kenneth More; Anthony Masaquel; Tripthi Kamath; Annie Guerin; Raluca Ionescu-Ittu; Marjolaine Gauthier-Loiselle; Roy Nitulescu; Nicholas Sicignano; Brian Barnett; Eric Q. Wu
117.3 billion (76%) compared to individuals without schizophrenia. The largest components were excess costs associated with unemployment (38%), productivity loss due to caregiving (34%), and direct health care costs (24%). CONCLUSIONS Schizophrenia is associated with a significant economic burden where, in addition to direct health care costs, indirect and non-health care costs are strong contributors, suggesting that therapies should aim at improving not only symptom control but also cognition and functional performance, which are associated with substantial non-health care and indirect costs.
SpringerPlus | 2016
Christopher Gallagher; Kenneth More; Anthony Masaquel; Tripthi Kamath; Annie Guerin; Raluca Ionescu-Ittu; Roy Nitulescu; Marjolaine Gauthier-Loiselle; Nicholas Sicignano; Elizabeth Butts; Eric Q. Wu; Brian Barnett
Abstract Objective: Chronic myeloid leukemia (CML) treatment relies on tyrosine kinase inhibitors (TKIs), but their use can be associated with low-grade adverse events (AEs). This analysis aimed to identify the low-grade AEs which significantly impact the Health Related Quality of Life (HRQoL) of CML patients in chronic phase (CP) and to compare the incidence of such AEs among nilotinib- and imatinib-treated patients. Research design and methods: Data from the 48 month ENESTnd trial were used (N = 593 patients). HRQoL was assessed using generic (SF-36) and leukemia-specific (FACT-Leu) HRQoL surveys. AEs were categorized into 26 system organ classes. Results: In the adjusted regression model, five low-grade AE categories – gastrointestinal disorders, blood and lymphatic system disorders, general disorders and administration site conditions, musculoskeletal disorders, and psychiatric disorders – significantly impaired at least one HRQoL score. The incidence rate of these five AE categories was either significantly lower for nilotinib than imatinib or not different between the two drugs. The AE categories with lower incidence for both nilotinib 300 mg BID and 400 mg BID versus imatinib 400 mg daily were gastrointestinal, blood and lymphatic system, and musculoskeletal; nilotinib 300 mg BID had lower incidence than imatinib for general disorders. Limitations: Low-grade AEs were grouped and analyzed by system organ class category, so the effect of some rare individual AEs on HRQoL may have been missed. Conclusions: The impact of low-grade AEs on HRQoL should be taken into account, along with other factors, when selecting the optimal treatment for patients newly diagnosed with CML-CP.
Breast Cancer Research and Treatment | 2016
Christopher Gallagher; Kenneth More; Tripthi Kamath; Anthony Masaquel; Annie Guerin; Raluca Ionescu-Ittu; Marjolaine Gauthier-Loiselle; Roy Nitulescu; Nicholas Sicignano; Elizabeth Butts; Eric Q. Wu; Brian Barnett
Abstract Objective: Brain metastases (BM) are highly prevalent among anaplastic lymphoma kinase positive (ALK+) non-small cell lung cancer (NSCLC) patients; yet little is known about their real-world treatment patterns and clinical and economic burdens. This study aimed to describe these patients’ treatment patterns, symptoms, and costs. Research design and methods: Retrospective study pooling data from three large administrative databases in the US (08/2011–06/2013). ALK+ NSCLC patients with BM and continuous enrollment for ≥ 60 days before and ≥30 days after the first observed BM diagnosis were identified by pharmacy records for crizotinib among patients with lung cancer and BM diagnostic codes. Main outcome measures: Treatment patterns, symptoms, healthcare resource utilization, and costs, before and after BM diagnosis. Results: Of the 213 crizotinib patients with BM diagnoses meeting the selection criteria, 23.0% had BM prior to NSCLC diagnosis; 47.4% had BM prior to crizotinib initiation; 19.2% during crizotinib treatment; and 10.3% post-crizotinib treatment. For those diagnosed with BM after NSCLC diagnosis, the median time between the NSCLC and BM diagnoses was 88 days. Following the first observed BM diagnosis, 88.7% used chemotherapy, 63.4% had radiotherapy, and 31.9% had stereotactic radiosurgery. The prevalence of BM-related symptoms substantially increased post-BM-diagnosis: fatigue (from 15% to 39%), headaches (from 5% to 24%), and depression (from 5% to 15%). Monthly costs per patient averaged