Ryuichi Akimoto

Blue rubber bleb nevus syndrome: report of a case.

SummaryA 21-year-old man had blue rubber bleb nevus syndrome: 1) hemangiomas of the skin all over the body; 2) hemangiomas of the digestive system; 3) iron-deficiency anemia. A giant mass of hemangiomas in the tranverse colon was resected surgically.

Lymphangioma of the transverse colon treated by transendoscopic polypectomy

This report concerns a 73-year-old man complaining of intermittent, dull, umbilical pain of one months duration. Barium-enema examination and endoscopy revealed a hemispheric cystic tumor at the midportion of the transverse colon, and the presumptive diagnosis was cystic submucosal tumor of the colon. Transendoscopic polypectomy was performed and the bulk of the lesion was locally excised from the colonic mucosa. Histologic examination revealed cavernous lymphangioma originating from the submucosa.

Gastric plasmacytoma. An immunologic and immunohistochemical study

A case of IgG (λ) secreting plasmacytoma arising in the stomach has been presented. Immunohistochemically, the tumor cells contained IgG‐lambda immunoglobulin. Immunoelectrophoretic study on patients serum revealed in the gamma zone the presence of M protein which reacted specifically with anti‐IgG and anti‐lambda antisera. Agar electrophoresis and immunofixation electrophoresis with anti‐IgG and anti‐lambda antisera showed multiple subbands. Neuraminidase treatment of the purified IgG from this patient resulted in gradual reduction of four subbands to two. Electrophoretic charge difference of the monoclonal immunoglobulin may be attributed to incompletely synthesized sugar chains attached to the protein core.

Transplantation of preserved pancreatic islets into the portal vein of rats.

Langerhans islets were isolated from the exocrine pancreata of Wistar rats by the improved collagenase-digestion method. The isolated islets were preserved in a tissue culture medium for seven days. Transplantation of these preserved islets into the portal vein of streptozotocin-induced diabetic rats resulted in a significant reduction of hyperglycemia, polyuria and glucosuria, and a restoration of weight gain. It was found that these effects could be maintained for 16 weeks. In order to normalize the K-values and plasma insulin levels, at least 600 islets had to be transplanted into each diabetic rat.