Ryuji Tachikawa

Extension of Bischler-Napieralski reaction—I : Synthesis of isoquinoline derivatives: A synthesis of rac.-apomorphine dimethyl ether

Abstract The scope of Bischler-Napieralski reaction has now been extended to include acyl cyclo-hexa-1:4-dienylethylamide types, which cyclise smoothly to yield various isoquinolines after dehydrogenation. 1-(2-Nitro-3:4-dimethoxybenzyl)-3:4-dihydroisoquinoline, hitherto difficultly accessible, could be prepared and converted to rac.-apomorphine dimethyl ether.

Studies of oxazolobenzodiazepines. Part 7. Synthesis of 3-methyloxazolo[3,2-d][1,4]benzodiazepines and configurational studies of their ketimine intermediates

Some 3-substituted oxazolo[3,2-d][1,4]benzodiazepines have been synthesized by a novel double-cyclization reaction, and the geometrical configurations of their ketimine intermediates have been investigated by n.m.r. spectroscopy and X-ray analysis.