Saad S. Elmorsy

The direct production of tri- and hexa-substituted benzenes from ketones under mild conditions

Treatment of aryl methyl ketones with tetrachlorosilane in ethanol gives good yields of 1,3-5-triarylbenzenes. Triannulated benzenes result from cyclopentanone and cyclohexanone.

A facile and convenient synthesis of substituted tetrazole derivatives from ketones or α,β-unsaturated ketones

Abstract Triazidochlorosilane (SiCl 4 - NaN 3 in situ) is a new and efficient reagent for the direct conversion of ketones or α,β-unsaturated ketones to the corresponding tetrazole derivatives in nearly quantitative yield.

A NOVEL APPROACH FOR THE SYNTHESIS OF 5-SUBSTITUTED TETRAZOLE DERIVATIVES FROM PRIMARY AMIDES IN MILD ONE-STEP METHOD

Abstract A new mild one-step method for the conversion of primary acid amides to 5-substituted tetrazoles in nearly quantitative yields employing triazidochlorosilane (TACS) is reported.

Synthesis of triazidochlorosilane (TACS). A novel silicon mediated one pot conversion of aldehydes to nitriles

Abstract Synthesis, structure elucidation of triazidochlorosilane (TACS) and a novel conversion of aldehydes to nitriles in one pot reaction on treatment with TACS (SiCl 4 NaN 3 in Situ) reagent in acetonitrile are described.

Oxidation of aldehydes to acyl azides using triazidochlorosilane (TACS)-active manganese dioxide reagent

Abstract Triazidochlorosilane (TACS) — active manganese dioxide is a new and versatile system for the efficient oxidation of aldehydes to the corresponding acyl azides at 0 °C, in dichloromethane.

A Convenient Regiospecific Synthesis of New Conjugated Tetrazole Derivatives via the Reaction of Dienones with the Tetrachlorosilane-Sodium Azide Reagent and their NMR Structural Assignment

Summary. Several new 1-aryl-, aralkyl-, and heteroaryl-5-(4-phenylbuta-1,3-dienyl)tetrazole derivatives and annulated tetrazole derivatives were efficiently and regiospecifically prepared in nearly quantitative yield via a facile one step reaction of dienones with a combination of tetrachlorosilane and sodium azide in acetonitrile under mild conditions. A complete structure assignment of three representative examples of the tetrazoles was achieved by advanced 2D NMR measurements including COSY, TOCSY, HSQC, HMBC, NOESY, and ROESY experiments.

Investigations of the tetrachlorosilane-ethanol induced self condensations of ketones.

Silicon tetrachloride-ethanol induced self condensation of ketones to yield tri- or hexasubstituted benzenes, can be diverted in a variety of ways, dependent on the steric hindrance of the ketone. A number of examples of cyclic ketone condensations are given, and the surprising result from condensation of propiophenone as compared with acetophenone is presented. The SiCl4/EtOH induced reactions of ketones to give benzenoids may be diverted at the second aldol condensation or at the cyclisation stage.

New routes for synthesis of branched functionalized benzenoid compounds by using tetrachlorosilaneethanol reagent

Abstract The successive reactions of some cyclic ketones with aryl methyl ketones mediated by tetrachlorosilane-ethanol, provide an attractive and convenient route to branched functionalized benzenoid compounds. Selective unsymmetrical branched triarylbenzenes have synthesized by inducing the reaction of ketones with dypnones in quantitative yields.

Novel Uncatalyzed Hydrocyanation of Ketones utlizing Tetrachlorosilane–Potassium Cyanide Reagent

Abstract A combination of tetrachlorosilane and potassium cyanide (in situ trichlorosilyl cyanide) was found to work efficiently for hydrocyanation of ketones to afford the corresponding cyanohydrins in high yield under mild conditions.

Chemoselective Bromination in a Two-Step Substitution Under the Influence of Tetrachlorosilane and N-Bromosuccinimide

The synthesis of gem dibromide carbonyl compounds via a cheep and readily available combined reagent from tetrachlorosilane and N-bromosuccinimide (TCS-NBS).