Tarek A. Salama

A Convenient Regiospecific Synthesis of New Conjugated Tetrazole Derivatives via the Reaction of Dienones with the Tetrachlorosilane-Sodium Azide Reagent and their NMR Structural Assignment

Summary. Several new 1-aryl-, aralkyl-, and heteroaryl-5-(4-phenylbuta-1,3-dienyl)tetrazole derivatives and annulated tetrazole derivatives were efficiently and regiospecifically prepared in nearly quantitative yield via a facile one step reaction of dienones with a combination of tetrachlorosilane and sodium azide in acetonitrile under mild conditions. A complete structure assignment of three representative examples of the tetrazoles was achieved by advanced 2D NMR measurements including COSY, TOCSY, HSQC, HMBC, NOESY, and ROESY experiments.

New routes for synthesis of branched functionalized benzenoid compounds by using tetrachlorosilaneethanol reagent

Abstract The successive reactions of some cyclic ketones with aryl methyl ketones mediated by tetrachlorosilane-ethanol, provide an attractive and convenient route to branched functionalized benzenoid compounds. Selective unsymmetrical branched triarylbenzenes have synthesized by inducing the reaction of ketones with dypnones in quantitative yields.

Novel Uncatalyzed Hydrocyanation of Ketones utlizing Tetrachlorosilane–Potassium Cyanide Reagent

Abstract A combination of tetrachlorosilane and potassium cyanide (in situ trichlorosilyl cyanide) was found to work efficiently for hydrocyanation of ketones to afford the corresponding cyanohydrins in high yield under mild conditions.

A New Approach to the Stereoselective Synthesis of β-Methylchalcones

Many β-methylchalcone derivatives are prepared via the self condensation of aralkyl ketones mediated by tetrachlorosilane–ethanol under mild conditions.