Sachiko Sakakibara
Bayer
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Publication
Featured researches published by Sachiko Sakakibara.
Bioorganic & Medicinal Chemistry Letters | 2003
Toshiki Murata; Mitsuyuki Shimada; Sachiko Sakakibara; Takashi Yoshino; Hiroshi Kadono; Tsutomu Masuda; Makoto Shimazaki; Takuya Shintani; Kinji Fuchikami; Katsuya Sakai; Hisayo Inbe; Keisuke Takeshita; Toshiro Niki; Masaomi Umeda; Kevin B. Bacon; Karl Ziegelbauer; Timothy B. Lowinger
IkappaB kinase beta (IKK-beta) is a serine-threonine protein kinase critically involved in the activation of the transcription factor Nuclear Factor kappa B (NF-kappaB) in response to various inflammatory stimuli. We have identified a small molecule inhibitor of IKK-beta. Optimization of the lead compound resulted in improvements in both in vitro and in vivo potency, and provided IKK-beta inhibitors exhibiting potent activity in an acute cytokine release model (LPS-induced TNFalpha).
Bioorganic & Medicinal Chemistry Letters | 2004
Toshiki Murata; Mitsuyuki Shimada; Sachiko Sakakibara; Takashi Yoshino; Tsutomu Masuda; Takuya Shintani; Hiroki Sato; Yuji Koriyama; Keiko Fukushima; Noriko Nunami; Megumi Yamauchi; Kinji Fuchikami; Hiroshi Komura; Akihiko Watanabe; Karl Ziegelbauer; Kevin B. Bacon; Timothy B. Lowinger
Bioorganic & Medicinal Chemistry Letters | 2004
Toshiki Murata; Mitsuyuki Shimada; Hiroshi Kadono; Sachiko Sakakibara; Takashi Yoshino; Tsutomu Masuda; Makoto Shimazaki; Takuya Shintani; Kinji Fuchikami; Kevin B. Bacon; Karl Ziegelbauer; Timothy B. Lowinger
Bioorganic & Medicinal Chemistry Letters | 2005
Miyuki Tatsuta; Mikayo Kataoka; Kayo Yasoshima; Sachiko Sakakibara; Yuka Shogase; Makoto Shimazaki; Takeshi Yura; Yingfu Li; Noriyuki Yamamoto; Jang Bahadur Gupta; Klaus Urbahns
Archive | 1999
Joachim Mittendorf; Rolf Henning; Siegfried Raddatz; Karl-Heinz Schlemmer; Makiko Hiraoka; Hiroshi Kadono; Muneto Mogi; Toshiya Moriwaki; Toshiki Murata; Sachiko Sakakibara; Mitsuyuki Shimada; Nagahiro Yoshida; Takashi Yoshino
Bioorganic & Medicinal Chemistry Letters | 2005
Miyuki Tatsuta; Mikayo Kataoka; Kayo Yasoshima; Sachiko Sakakibara; Yaka Shogase; Makoto Shimazaki; Takeshi Yura; Yingfu Li; Noriyuki Yamamoto; Jang Bahadur Gupta; Klaus Urbahns
Bioorganic & Medicinal Chemistry Letters | 2003
Toshiki Murata; Mitsuyuki Shimada; Sachiko Sakakibara; Takashi Yoshino; Kiroshi Kadono; Tsutomu Masuda; Makoto Shimazaki; Takuya Shintani; Kinji Fuchikami; Katsuya Sakai; Hisayo Inbe; Keisuke Takeshita; Toshiro Niki; Masaomi Umeda; Kevin B. Bacon; Karl Ziegelbauer; Timothy B. Lowinger
Archive | 2001
Kinji Fuchikami; Hiroshi Kadono; Hiroshi Komura; Yuji Koriyama; Timothy B. Lowinger; Tsutomu Masuda; Toshiki Murata; Sachiko Sakakibara; Hiroki Sato; Mitsuyuki Shimada; Takuya Shintani; Masaomi Umeda; Takashi Yoshino; Karl Ziegelbauer
Archive | 2001
Toshiki Murata; Sachiko Sakakibara; Takashi Yoshino; Yuka Ikegami; Tsutomu Masuda; Mitsuyuki Shimada; Takuya Shintani; Makoto Shimazaki; Timothy B. Lowinger; Karl Ziegelbauer; Kinji Fuchikami; Masaomi Umeda; Hiroshi Komura; Nagahiro Yoshida
Archive | 2001
Kinji Fuchikami; Hiroshi Kadono; Hiroshi Komura; Yuji Koriyama; Timothy B. Lowinger; Tsutomu Masuda; Toshiki Murata; Sachiko Sakakibara; Hiroki Sato; Mitsuyuki Shimada; Takuya Shintani; Masaomi Umeda; Takashi Yoshino; Karl Ziegelbauer
