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Dive into the research topics where Saima Rajabali is active.

Publication


Featured researches published by Saima Rajabali.


Antioxidants & Redox Signaling | 2012

Lung injury in preterm neonates: the role and therapeutic potential of stem cells.

Rajesh S. Alphonse; Saima Rajabali; Bernard Thébaud

Continuous improvements in perinatal care have allowed the survival of ever more premature infants, making the task of protecting the extremely immature lung from injury increasingly challenging. Premature infants at risk of developing chronic lung disease or bronchopulmonary dysplasia (BPD) are now born at the late canalicular stage of lung development, just when the airways become juxtaposed to the lung vasculature and when gas-exchange becomes possible. Readily available strategies, including improved antenatal management (education, regionalization, steroids, and antibiotics), together with exogenous surfactant and exclusive/early noninvasive ventilatory support, will likely decrease the incidence/severity of BPD over the next few years. Nonetheless, because of the extreme immaturity of the developing lung, the extent to which disruption of lung growth after prematurity and neonatal management lead to an earlier or more aggravated decline in respiratory function in later life is a matter of concern. Consequently, much more needs to be learned about the mechanisms of lung development, injury, and repair. Recent insight into stem cell biology has sparked interest for stem cells to repair damaged organs. This review summarizes the exciting potential of stem cell-based therapies for lung diseases in general and BPD in particular.


Stem Cells Translational Medicine | 2016

Functional Differences Between Placental Micro- and Macrovascular Endothelial Colony-Forming Cells

Ioana Solomon; Megan O’Reilly; Lavinia Ionescu; Rajesh S. Alphonse; Saima Rajabali; Shumei Zhong; Arul Vadivel; W. Chris Shelley; Mervin C. Yoder; Bernard Thébaud

Alterations in the development of the placental vasculature can lead to pregnancy complications, such as preeclampsia. Currently, the cause of preeclampsia is unknown, and there are no specific prevention or treatment strategies. Further insight into the placental vasculature may aid in identifying causal factors. Endothelial colony‐forming cells (ECFCs) are a subset of endothelial progenitor cells capable of self‐renewal and de novo vessel formation in vitro. We hypothesized that ECFCs exist in the micro‐ and macrovasculature of the normal, term human placenta. Human placentas were collected from term pregnancies delivered by cesarean section (n = 16). Placental micro‐ and macrovasculature was collected from the maternal and fetal side of the placenta, respectively, and ECFCs were isolated and characterized. ECFCs were CD31+, CD105+, CD144+, CD146+, CD14−, and CD45−, took up 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethyl‐indocarbocyanine perchlorate‐labeled acetylated low‐density lipoprotein, and bound Ulex europaeus agglutinin 1. In vitro, macrovascular ECFCs had a greater potential to generate high‐proliferative colonies and formed more complex capillary‐like networks on Matrigel compared with microvascular ECFCs. In contrast, in vivo assessment demonstrated that microvascular ECFCs had a greater potential to form vessels. Macrovascular ECFCs were of fetal origin, whereas microvascular ECFCs were of maternal origin. ECFCs exist in the micro‐ and macrovasculature of the normal, term human placenta. Although macrovascular ECFCs demonstrated greater vessel and colony‐forming potency in vitro, this did not translate in vivo, where microvascular ECFCs exhibited a greater vessel‐forming ability. These important findings contribute to the current understanding of normal placental vascular development and may aid in identifying factors involved in preeclampsia and other pregnancy complications.


Journal of Clinical and Experimental Cardiology | 2012

The Emerging Role of Stem/Progenitor Cells in Pulmonary Vascular Disease

Saima Rajabali; Duncan J. Stewart; Shirley H. J. Mei; Bernard Thbaud

Pulmonary hypertension is a severe disease characterized by small pulmonary artery obstruction from vascular proliferation and remodeling leading to elevated mean pulmonary arterial pressure, increased pulmonary vascular resistance, right ventricular failure and death. Current treatments include prostacyclin analogs, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors, which largely address mechanisms of endothelial dysfunction that were identified over 2 decades ago. Despite advances in understanding the disease mechanisms and the development of new pharmacological therapies, the prognosis of pulmonary hypertension remains poor. Recent advances in stem cell biology have unraveled the potential of stem/progenitor cells to repair damaged organs and offer the possibility for cell-based treatment for intractable diseases. This review summarizes the emerging role of stem/progenitor cells in the pathophysiology and the treatment of pulmonary hypertension.


Trials | 2015

Continence Across Continents To Upend Stigma and Dependency (CACTUS-D): study protocol for a cluster randomized controlled trial

Cara Tannenbaum; Eleanor van den Heuvel; Xavier Fritel; Kenneth Southall; Jeffrey W. Jutai; Saima Rajabali; Adrian Wagg


ics.org | 2018

Effect of pad use on quality of life in women with urinary incontinence: a mixed methods study

Megan McCreary; Kathleen F. Hunter; Saima Rajabali; Ian Milsom; Adrian Wagg


ics.org | 2018

Containment products and quality of life in men with urinary incontinence: an exploratory, qualitative study

Stephanie Gartner; Kathleen F. Hunter; Megan McCreary; Cody Lindeman; Saima Rajabali; Adrian Wagg


Neurourology and Urodynamics | 2018

Containment products and quality of life in men with light to moderate urinary incontinence: an exploratory analysis.

Saima Rajabali; Megan McCreary; Stephanie Gartner; Kathleen F. Hunter; Cody Lindeman; Adrian Wagg


Neurourology and Urodynamics | 2018

Preferences for continence care at end of life: a qualitative study

Nicholas Smith; Kathleen F. Hunter; Saima Rajabali; Robin Fainsinger; Adrian Wagg


Neurourology and Urodynamics | 2017

Systematic Trial Of Pad Information uTility (STOPIT): Women’s sources of information, knowledge and use of continence products: a mixed methods study.

Nicholas Smith; Saima Rajabali; Ian Milsom; Kathleen F. Hunter; Adrian Wagg


Neurourology and Urodynamics | 2017

Is the belief that urinary incontinence is normal for aging related to older women’s experience of UI?

Christina Shaw; Saima Rajabali; Quazi Ibrahim; Cara Tannenbaum; Adrian Wagg

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Bernard Thébaud

Children's Hospital of Eastern Ontario

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Ian Milsom

University of Gothenburg

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Arul Vadivel

Children's Hospital of Eastern Ontario

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Duncan J. Stewart

Ottawa Hospital Research Institute

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