Serban Fleschin

Application of Fourier Transform Infrared Spectrophotometry in Pharmaceutical Drugs Analysis

Abstract This review provides some background to infrared spectroscopy including Fourier transform infrared spectroscopy. It is not meant to be complete or exhaustive but to provide the reader with sufficient background for selected applications in pharmaceutical analysis. Fourier transform infrared spectroscopy (FTIR) is a fast and nondestructive analytical method. Associated with chemometrics, it can become a powerful tool for the pharmaceutical industry. Indeed, it is suitable for analysis of solid, liquid, and biotechnological pharmaceutical forms. This review focuses on pharmaceutical FTIR applications used for qualitative and quantitative analysis. Moreover, it can be implemented during pharmaceutical development, in production for process monitoring, and in quality control laboratories.

Enalapril and Ramipril Selective Membranes

The construction and general performance characteristics of potentiometric plastic-membrane sensors for enalapril and ramipril drug-anions, are described. The electroactive materials are based on i...

Recent Applications of Fourier Transform Infrared Spectrophotometry in Herbal Medicine Analysis

Abstract Fourier transform infrared spectroscopy (FTIR) is a fast and nondestructive analytical method. Associated with chemometrics, it is a powerful tool for the pharmaceutical industry. It is becoming a suitable technique for analysis of herbal medicine. This review focuses on the recent developments and updates for the qualitative and quantitative analysis of herbal medicine using FTIR. Moreover, it can be implemented during herbal drug development, in production for process monitoring, or in quality control laboratories.

FTIR Spectrophotometric Methods Used for Antioxidant Activity Assay in Medicinal Plants

Abstract: Fourier transform infrared spectroscopy (FTIR) is a fast and nondestructive analytical method. Associated with chemometrics, it is a powerful tool for research and industry. The present review discusses the antioxidant activities assay of some plants (fruits, leaves, aerian part) with medicinal properties using an FTIR spectrophotometric method in comparison with other ultraviolet-visible (UV-Vis) spectrophotometric methods. A good correlation was found between the different methods used for measuring the antioxidant capacity of some of these herbs.

ENALAPRIL MICROBIAL BIOSENSOR

Enalapril maleate (EMa) belongs to a new class of antihypertensive agents known as angiotensin converting enzyme (ACE) inhibitors. This paper describes the development of a microbial biosensor for EMa using induced Bacillus subitilis cells. This biosensor measures the acceleration of respiration during specific metabolic pathways of this drug. It has been applied, with good results, for determination of the active ingredient in the pharmaceutical tablet formulations.

ANALYSIS OF MEBENDAZOLE POLYMORPHS BY FOURIER TRANSFORM INFRARED SPECTROMETRY USING CHEMOMETRIC METHODS

A Fourier transform infrared (FT-IR) spectrometric method diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) was developed for the rapid, direct measurement of mebendazole in drugs. Conventional KBr-spectra and DRIFTS-spectra were compared for best determination of active substance in drug formulations. Two chemometric approaches, partial least-squares (PLS2) and principal component regression (PCR+) methods were used in data procesing. The best results were obtained with the PLS2 method.

Biomedical Investigations Using Fourier Transform-Infrared Microspectroscopy

One of the most exciting recent developments in infrared spectroscopy has been the coupling of the spectrometer to an infrared microscope. The combination of the new infrared spectrometer and a microscope was a natural thought of scientists in these fields. This development has been so rewarding and so useful in solving todays chemical problems that infrared microspectroscopy has quickly become a significant subclassification of infrared spectroscopy. Infrared microspectroscopy has a much longer history than the recent enthusiasm would imply, however. The great interest in the use of infrared spectroscopy to solve biomedical problems that occurred in recent years shortly spread into the medical and biological fields. The aim of this review is to discuss the new developments in applications of FT-IR microspectroscopy in biomedical analysis, covering the period between 2008 and 2013.

FT-IR Spectrophotometric Analysis of Ascorbic Acid and Biotin and their Pharmaceutical Formulations

Abstract Fourier transform–infrared (FT-IR) spectrometry was used for the rapid, direct measurement of ascorbic acid (vitamin C) and biotin (vitamin H) in different pharmaceutical products. Conventional KBr spectra were compared for the best determination of active substances in drug preparations. The Beer–Lambert law and chemometric approaches were applied in data processing.

A New Method for a Quantitative Determination of Piroxicam in Pharmaceutical Formulations Using FT-IR Spectrometry

A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, and direct measurement of piroxicam (Pir) in pharmaceutical drugs. Pir is a well known and very effective antiinflammatory drug. Pir can be determined by various methods and now we are adding a new one that uses a Fourier transform infrared spectrophotometric technique. Conventional spectra were compared for best determination of active substance in pharmaceutical formulations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were tried in data processing.

Synthesis and Analytical Characteristics of New Progesterone Skeleton Haptens

Abstract This article describes the synthesis of new conjugated progesterone‐bovine serum albumin substances, used to obtain specific antisera toward this hormone and for progesterone assay kits. In general, these kits are designed to be used on the farm or at the local veterinary clinics.