Shilpi Saxena

A novel one pot synthesis of nitrogen containing heterocycles: an alternate methodology to the Biginelli and Hantzsch reactionsElectronic supplementary information (ESI) available: General procedure for the synthesis of Biginelli tetrahydropyrimidines (2b???e) and 1,4-dihydropyridines 3a???e. See http://www.rsc.org/suppdata/p1/b2/b205539m/

Modified Biginelli and Hantzsch reactions were carried using environmentally benign processes. Neat reactants subjected to microwave radiation gave the required products more quickly and in better yields in comparison to traditional methodologies. The observed yields and enhancement in reaction rates are due to the solvent free conditions coupled with the use of microwave radiation.

Environmentally benign synthesis of benzopyranopyrimidines

An ecologically benign method has been proposed for the synthesis of benzopyranopyrimidines by reaction of 4-hydroxycoumarins with aldehydes and urea or thiourea in the absence of a solvent under microwave irradiation. The proposed procedure improves the product yield and shortens the reaction time.

Solid-supported Hantzsch—Biginelli reaction for syntheses of pyrimidine derivatives

The microwave-assisted dry media technology was utilized for the synthesis of some novel derivatives in the Hantzsch—Biginelli reaction. In this eco-friendly approach, the usage of organic solvents and hazardous reagents resulting in corrossion of materials was minimized, giving high yields of products within a short reaction time.

Isotopic-Chemical Framework of Groundwater Aquifer to Study the Pollution Dynamics at Delhi, India

Indiscriminate disposal of anthropogenic wastes and leaching of pollutants from these resulted in an ever-increasing threat to the quality of ground water resource base. Large-scale groundwater withdrawal for domestic, commercial, and industrial purposes leads to widespread decline of ground water table. For protection of groundwater from pollution (Singhal et al., 2003 and Singh et al., 1997), it is a matter of concern for the planners and decision makers to clearly characterize the groundwater renewal, quality of water and causes of its deterioration, sources of pollution, trace the movement of pollutants and containment of spreading from known sources. The characteristics of pollutants level and transport in groundwater are associated with variations in one or two parameters at one scale and several parameters at another scale. In order to understand the groundwater system (Glynn et al., 2005) and its hydro chemical and pollutant transport study for the Najafgarh drain basin area, a detailed study has been undertaken about the major ions and isotopic signatures of groundwater of the Najafgarh drain basin area of Delhi (Shivanna et al., 1998).

Solvent-free synthesis of 2,4,6-triaryl pyridines

A modified method to prepare 1,3,5-triarylpyridines by a [3+2+1] ring annulation reaction is described. Three-component condensation of neat reactants when subjected to microwaves afforded the required product in shorter reaction time with higher yield in comparison to conventional methodologies. The microwave accelerated reaction technique without external solvent renders the whole synthesis into a truly ecofriendly protocol.