Soo-Hyung Jeon

Effects of a Herbal Medicine, Yukgunja-Tang, on Functional Dyspepsia Patients Classified by 3-Dimensional Facial Measurement: A Study Protocol for Placebo-Controlled, Double-Blind, Randomized Trial

Introduction. Functional dyspepsia (FD), a common upper gastrointestinal disease, is difficult to manage because of the limitations of current conventional treatments. Yukgunja-tang (YGJT) is widely used to treat FD in clinical practice in Korea, Japan, and China. However, YGJT significantly improves few symptoms of FD. In Korean medicine, FD is a well-known functional gastric disease that shows difference in the effect of herbal medicine depending on constitution or type of Korean medicine diagnosis. This study aims to investigate the efficacy of YGJT on FD patients classified by 3-dimensional facial measurement using a 3-dimensional facial shape diagnostic system (3-FSDS). Methods. A placebo-controlled, double-blind, randomized, two-center trial will be performed to evaluate the efficacy of YGJT on FD patients. Eligible subjects will be initially classified as two types by 3-dimensional facial measurement using the 3-FSDS. Ninety-six subjects (48 subjects per each type) will be enrolled. These subjects will be randomly allocated into treatment or control groups in a 2 : 1 ratio. YGJT or placebo will be administered to each group during the 8-week treatment period. The primary outcome is total dyspepsia symptom scale, and the secondary outcomes include single dyspepsia symptom scale, proportion of responders with adequate symptom relief, visual analog scale, Nepean dyspepsia index-Korean version, functional dyspepsia-related quality of life, and spleen qi deficiency questionnaire. Discussion. This is the first randomized controlled trial to assess the efficacy of the YGJT on FD patients classified by 3-dimensional facial measurement. We will compare the treatment effect of the YGJT on FD patients classified as two types using the 3-FSDS. The results of this trial will help the FD patients improve the symptoms and quality of life effectively and provide objective evidence for prescribing the YGJT to FD patients in clinical practice. Trial Registration. This trial is registered with Clinical Research Information Service Identifier: KCT0001920, 15 May, 2016.

A Validation Study of the Sasang Constitution Questionnaire for Japanese(SSCQ-J)

A Validation Study of the Sasang Constitution Questionnaire for Japanese(SSCQ-J) Hoon-Seuk Jo, Soo-Hyung Jeon, Jong-Hun Jeong, Kyu-Kon Kim†, Jong-Won Kim Dept. of Korean Medicine, Graduate School, Dong-Eui University Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dongeui Univ. †Dept. of Data Information Science, Dongeui Univ. Objectives This study was aimed to validate Sasang Constitution Questionnaire for Japanese (SSCQ-J). Methods Sasang Constitution Questionnaire for Patients (SSCQ-P) was developed by joint researches between the Society of Sasang Constitutional Medicine and Korea Institute of Oriental Medicine. We translated SSCQ-P into Japanese and modified some items of that for Japanese. By getting approval from the Institutional Review Board(IRB)of School of Medicine, Keio University, we conducted a questionnaire survey of patients who visited Oriental Medicine Center from early January until mid-February 2011. The total of 364 patients filled out that Questionnaire and gave an interview with a Sasang constitution specialist. Using this Questionnaire data, we made Sasang constitutional classification functions and calculated diagnostic accuracy rate of SSCQ-J using discrimination analysis. Results 1. Male groups diagnostic accuracy rate of SSCQ-J was 77.01% and female was 78.10%. 2. Diagnostic accuracy of SSCQ-J was a little higher than SSCQ-P Conclusions 1. SSCQ-J can be considered to have good discriminant power compared with SSCQ-P 2. Further research with SSCQ-J will be helpful in the comparison study on the usual symptoms between Korean and Japanese as well as development of good discriminant function.

A Comparative Study on Responses to the Sasang Constitution Questionnaire for Patients between Korean and Japanese

Abstract A Comparative Study on Responses to the Sasang Constitution Questionnaire for Patients between Korean and Japanese Dong-Hoon Ryu, Jong-Hoon Jeong, U-Yeol Bae ∗ , Kyu-Kon Kim † , Soo-Hyung Jeon, Jong-Won KimDept. of Sasang Constitutional Medicine, College of Koreanl Medicine, Dongeui Univ. ∗ Dept. of Oriental Rehabilitation, College of Korean Medicine, Dongeui Univ. † Dept. of Information Statistics, Dongeui Univ.ObjectivesThis study was performed to compare responses of Korean to the Sasang Constitution questionnaire with those of Japanese and to learn difference in characteristic according to the Sasang Constitution between two countries.Methods301 Korean visiting the department of the Sasang Constitution, Dong-Eui Medical Center in Busan, Korea from November 2006 to September 2010 responded to the SSCQ-P(Sasang Constitution Questionnaire for Patients). Sasang Constitution specialist interviewed subjects and diagnosed their Sasang Constitution. 361 Japanese visitingthe center for Kampo Medicine, Keio University in Tokyo, Japan from January 2010 to February 2011 respondedthe SSCQ-J(Sasang Constitution Questionnaire for Japanese). The Sasang Constitution was diagnosed in the same way as Korean. We compare responses to the SSCQ-P in Korean with those to the SSCQ-J in Japanese.Results1. Among Soyangin related 58 items of Sasang Constitution questionnaire, 26, 46.36% items had statistically significant response results in both Korean and Japanese and response disposition of all these items was same.Among Taeeumin related 68items, 36, 52.94% items had statistically significant response results in both Koreanand Japanese. Of these, response disposition of 35 items was same and that of 1 item was different. Among Soeumin related 71 items, 31, 43.66% items had statistically significant response results in both Korean and Japanese. Of these, response disposition of 28 items was same and that of 3 items was different.2. The proportion of items having statistical significance and same disposition in both Korean and Japanese by Sasang Constitutional characteristic category[Features and Way of Speaking, Physical Appearance, Temperament and Talent, Pathological Syndromes] was as follows; In Soyangin, the proportion in Pathological Syndromes was 27.8% and that in the others was more than 41.7%.In Taeeumin, the proportion in Pathological Syndromes was 33.3% and that in the others was more than 57.9%. In Soeumin, the proportion in Features and Way of Speaking was 70.6%, that in Physical Appearance was 8.3% and that in the others was 30∼40%.

An Herbal Medicine, Yukgunja-Tang is more Effective in a Type of Functional Dyspepsia Categorized by Facial Shape Diagnosis: A Placebo-Controlled, Double-Blind, Randomized Trial

Introduction Functional dyspepsia (FD) is a functional gastrointestinal disorder characterized by persistent upper dyspeptic symptoms without organic lesions. There is no standard therapy for FD. Yukgunja-tang (YGJT) is an herbal medicine used for treating upper gastrointestinal symptoms in Asia. Studies on the effect of YGJT on FD have been conducted. However, the results were inconsistent. In Hyungsang medicine, traditional Korean medicine, FD patients are classified into bladder body (BB) or gallbladder body (GB) subtypes by the shape and angle of their faces. Each subtype may have different characteristics, physiology, and pathology of the same disease. YGJT is more effective for patients with BB subtype. The three-dimensional facial shape diagnostic system (3-FSDS) was shown to be effective in diagnosing BB or GB subtypes. This study aimed to investigate the effect of YGJT on FD patients classified using the 3-FSDS. Materials and Methods The current study was a placebo-controlled, double-blinded, randomized, two-center trial. Eligible patients were diagnosed with either BB or GB FD subtype using the 3-FSDS. Ninety-six participants (48 BB and 48 GB subtypes) were randomly allocated to treatment or control groups in a 2:1 ratio. YGJT or placebo was administered for eight weeks. The primary outcome was assessed using the total dyspepsia symptom scale (TDS), while the secondary outcomes were assessed using the single dyspepsia symptom scale (SDS), proportion of responders, visual analog scale, Nepean dyspepsia index, functional dyspepsia-related quality of life, and spleen qi deficiency questionnaire. Results and Discussion The result of TDS showed the superior effect of YGJT on BB over GB subtype. The subgroup analysis of TDS and SDS scores showed the superior effect of YGJT over placebo. Other outcome variables did not show any significant differences between groups. Conclusion YGJT may be considered for FD patients diagnosed with BB subtype using 3-FSDS.

The Research of Corelation between Sasang Constitution and Pattern Identification through Clinical Research of the Patients of Menstrual Pain

The Research of Corelation between Sasang Constitution and Pattern Identification through Clinical Research of the Patients of Menstrual Pain Seok-Hwan Kang, Soo-Hyung Jeon, In-Seon Lee, Kyu-Kon Kim, Young-Ju Na, Jong-Won Kim Dept. of Sasang Constitutional Medicine, Ulsan Korean Medical Hospital of Dong-eui Univ. Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Dong-eui Univ. Dept. of Obstetrics & Gynecology, College of Korean Medicine, Dong-eui Univ. Dept. of Information Statistics, Dong-eui Univ. Dept. of Sasang Constitutional Medicine, Korean Medical Hospital of Dong-eui Univ. Objective We researched to analyze correlation between menstrual pain and Korean medical diagnosis – Sasang constitution and Pattern Identification through clinical research of the patients of menstrual pain. Method Trial gruop who consists of women with menstrual pain is 193 people, and control group who consists of women without menstrual pain is 101 people. We producted analyzing of their Sasang Constitution and symptom with Diagnosis System of Oriental Medicine(DSOM). This study used chi-square test, two sample t-test, analysis of variance, Wilcoxon’s rank sum test, Kruskal-Wallis test, correlation analysis. Results 1) In trial and control group, Soeumin was the largest and Soyangin was the least. There was’nt statistical significance between trial and control group. 2) In DSOM, deficiency of blood, stagnation of qi, blood stasis, coolness, spleen, kidney and phlegm pathogenic factors showed significant difference. Conclusion There were significant corelation between menstrual pain and Korean mdical diagnosis – Sasang constitution and Pattern Identification.

A Study on the Response Differences to the Sasang Constitution Questionnaire by Sasang Constitutions in Adult Women with Menstrual Pain

A Study on the Response Differences to the Sasang Constitution Questionnaire by Sasang Constitutions in Adult Women with Menstrual Pain Young-Ju Na, Seok-Hwan Kang, Jong-Won Kim, Soo-Hyung Jeon Dept. of Sasang Constitutional Medicine, Korean Medical Hospital of Dong-eui Univ. Dept. of Sasang Constitutional Medicine, Ulsan Korean Medical Hospital of Dong-eui Univ. Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Dong-eui Univ. Objectives The purpose of this study was to investigate whether the menstrual pain affect the Sasang constitutions questionnaire response in adult women. Methods Using a structured menstrual history questionnaire, we evaluated the degree of menstrual pain of 550 adult women who participated in this clinical trial. Based on the survey we classified them into menstrual pain group and control group. They filled out SSCQ-P (Sasang Constitution Questionnaire for Patients) and we had compared the difference in response by Sasang constitutions. From 329 women in menstrual pain group and 212 women in control group, 541 questionnaire was analyzed statistically by their constitutions. Results 7 questions in Soyangin, 11 questions in Taeeumin and 20 questions in Soeumin were statistically significant in response between menstrual pain group and control group. Conclusions Soyangins menstrual pain shows less influence on SSCQ-P than Taeeumin and Soeumin. Taeeumin who has Taeyangins appearances and characteristics has more menstrual pain. In Soeumin, menstrual pain may result in negative and less expressive characteristics.

A Case Study of a Taeyangin Patient with Vertebrobasilar Insufficient after Mistreat as Taeeumin.

A Case Study of a Taeyangin Patient with Vertebrobasilar Insufficient after Mistreat as Taeeumin. Seok-Hwan KangᆞSoo-Hyung JeonᆞYoung-Ju NaᆞJong-Won Kim Dept. of Sasang Constitutional Medicine, Ulsan Korean Medical Hospital of Dong-eui Univ. Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Dong-eui Univ. Dept. of Sasang Constitutional Medicine, Korean Medical Hospital of Dong-eui Univ. Objectives This case study was about a Taeyangin patient with transient ischemic attack(TIA) due to vertebrobasilar insufficiency(VBI). In this study, we report the progress of mistreat with Taeyangin as Taeeumin and the improvement of symptoms after rediagnosis as Taeyangin. Methods Patient’s chief complain was weakness of lower limbs, dysarthria and dizziness. Patient first time took Taeeumin prescription such as Chunghyulganggi-tang, Chunsimyonja-tang and Sanyakbopaewon-tang. After occuring side effects we changed the prescription to Taeyangin herbal medicine such as Ogapijangchuk-tang gagam and Mihudeungsikjang-tang gagam. Result and Conclusion Patient suffered from diarrhea by taking Taeeumin prescription and symptom was continue. After changing of prescription to Taeyangin herbal medicine, not only chief symptom but also original symptom was improved.

Study on the Constitutional Distributions of Disease Types and Symptoms by Shisho Constitution in Outpatients at the Center for Kampo Medicine, Keio University

a Dept. of Sasang Constitutional Medicine, Dongeui University Ulsan Korean Medical Hospital, 282 Jungang-ro, Nam-gu, Ulsan 680-824, Korea b Center for Kampo Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan c Dept. of Kampo Pharmacy, Yokohama College of Pharmacy, 661 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan d Dept.of Sasang Constitutional Medicine, Dongeui University Korean Medical Hospital, 62 Yangjeong-ro, Busanjin-gu, Busan 614-710, Korea

Hematologic Characteristics of Stroke Inpatients according to Sasang Constitution in One Korean Medicine Hospital

Abstract Hematologic Characteristics of Stroke Inpatients according to Sasang Constitution in One Korean Medicine Hospital Soo-Hyung Jeon, Jong-Won Kim, Dong-Hoon Ryu, Kyu-Kon Kim ∗ , and Yong-Tae Lee † Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dongeui Univ. ∗ Dept. of Data Information Science, Dongeui Univ., † Dept. of Physiology, College of Oriental Medicine, Dongeui Univ.ObjectivesThe purpose of this study is to know hematologic characteristics of patients with stroke in Sasang ConstitutionalMedicine which will be helpful for the prevention and treatment of strokeMethodsWe collected data from 111 patients who received treatment as a stroke inpatient at one Korean medicine hospital in Busan, Korea. A Sasang Constitutional Medicine(SCM) specialist diagnosed their Sasang Constitutional types based on the four diagnosis standard of SCM and herbal medicine reaction. Results of hematologic tests were classified according to gender, age, stroke types and Sasang Constitutional types and analysed by SAS system. Results1. Males mean value of RBC count, Hemoglobin and Hematocrit was lower than normal range. 2. The mean value of hsCRP of above age 65 group was 3.19 times significantly higher than under age 65 group.3. The mean value of platelet of cerebral hemorrhage group was significantly higher than cerebral infarction group.4. The mean value of triglyceride of Taeeumin was significantly higher than Soyangin and Soeumin.Conclusions For the prevention of stroke, appropriate treatment of stress, trauma and infections is needed and male require a regular and balanced meals. Especially Taeeumin need to eat small meals to avoid excessive accumulation of energyKey Words: Stroke, Hematologic Tests, Triglycerides