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Soren Giese

Bristol-Myers Squibb

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Publication

Featured researches published by Soren Giese.

Bioorganic & Medicinal Chemistry Letters | 2008

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists

Mark E. Salvati; Aaron Balog; Weifang Shan; Richard Rampulla; Soren Giese; Tom Mitt; Joseph A. Furch; Gregory D. Vite; Ricardo M. Attar; Maria Jure-Kunkel; Jieping Geng; Cheryl A. Rizzo; Marco M. Gottardis; Stanley R. Krystek; Jack Z. Gougoutas; Michael A. Galella; Mary T. Obermeier; Aberra Fura; Gamini Chandrasena

A novel series of [2.2.1]-oxabicyclo imide-based compounds were identified as potent antagonists of the androgen receptor. Molecular modeling and iterative drug design were applied to optimize this series. The lead compound [3aS-(3aalpha,4beta,5beta,7beta,7aalpha)]-4-(octahydro-5-hydroxy-4,7-dimethyl-1,3-dioxo-4,7-epoxy-2H-isoindol-2-yl)-2-iodobenzonitrile was shown to have potent in vivo efficacy after oral dosing in the CWR22 human prostate tumor xenograph model.

Archive | 2002

Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Mark E. Salvati; James Aaron Balog; Dacia A. Pickering; Soren Giese; Aberra Fura; Wenying Li; Ramesh N. Patel; Ronald L. Hanson; Toomas Mitt; Jacques Y. Roberge; James R. Corte; Steven H. Spergel; Richard Rampulla; Raj N. Misra; Hai-Yun Xiao

Archive | 2002

Fused cyclic modulators of nuclear hormone receptor function

Mark E. Salvati; James Aaron Balog; Weifang Shan; Soren Giese; Lalgudi S. Harikrishnan

Archive | 2001

Fused cyclic compounds as modulators of nuclear hormone receptor function

Mark E. Salvati; James Aaron Balog; Weifang Shan; Soren Giese

Archive | 2002

Modulateurs cycliques fusionnes de la fonction du recepteur d'hormones nucleaire

Mark E. Salvati; James Aaron Balog; Weifang Shan; Soren Giese; Lalgudi S. Harikrishnan

Archive | 2002

Composes de succinimide heterocycliques lies par fusion et substances analogues, modulateurs de la fonction du recepteur hormonal nucleaire

Mark E. Salvati; James Aaron Balog; Dacia A. Pickering; Soren Giese; Aberra Fura; Wenying Li; Ramesh N. Patel; Ronald L. Hanson; Toomas Mitt; Jacques Y. Roberge; James R. Corte; Steven H. Spergel; Richard Rampulla; Raj N. Misra; Hai-Yun Xiao

Archive | 2002

Kondensierte zyklische modulatoren der funktion von nuklearen hormonrezeptoren

Mark E. Salvati; James Aaron Balog; Weifang Shan; Soren Giese; Lalgudi S. Harikrishnan

Archive | 2002

Kondensierte zyklische modulatoren der funktion von nuklearen hormonrezeptoren Condensed cyclic modulators of the function of nuclear hormone receptors

Mark E. Salvati; James Aaron Balog; Weifang Shan; Soren Giese; Lalgudi S. Harikrishnan

Archive | 2001

Kondensierte heterozyklische succinimid derivate und deren analoga, modulatoren der kern hormon rezeptor funktionen

Mark E. Salvati; James Aaron Balog; Dacia A. Pickering; Soren Giese; Aberra Fura; Wenying Li; Ramesh N. Patel; Ronald L. Hanson

Archive | 2001

Kondensierte heterocyclische Succinimidverbindungen und deren Analoga, Modulatoren der nukleären Hormonrezeptorfunktion Fused heterocyclic succinimide compounds and their analogues, modulators of nuclear hormone receptor function

Aaron Balog; Aberra Fura; Soren Giese; L. Ronald Morris Plains Hanson; Wenying Middletown Li; N. Ramesh Bridgewater Patel; A. Dacia Lawrenceville Pickering; E. Mark Lawrenceville Salvati

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Collaboration

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Mark E. Salvati

Bristol-Myers Squibb

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James Aaron Balog

Bristol-Myers Squibb

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Aberra Fura

Bristol-Myers Squibb

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Weifang Shan

Bristol-Myers Squibb

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Dacia A. Pickering

Bristol-Myers Squibb

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Lalgudi S. Harikrishnan

Bristol-Myers Squibb

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Ronald L. Hanson

Bristol-Myers Squibb

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Wenying Li

Bristol-Myers Squibb

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Aaron Balog

Bristol-Myers Squibb

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Richard Rampulla

Bristol-Myers Squibb

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