Sritanu Jana

Fine-needle aspiration cytology of retroperitoneal lesions: a 5-year experience with an emphasis on cytohistological discrepancy.

Background: The retroperitoneal space contains various organs which can be affected by various non-neoplastic and neoplastic pathological processes. A diagnosis of these retroperitoneal lesions is often difficult. Fine-needle aspiration cytology (FNAC) under image guidance is now becoming an effective tool for the initial evaluation of retroperitoneal lesions. Objective: The present study was undertaken to evaluate the role of ultrasound-guided FNAC in the diagnosis of retroperitoneal lesions in comparison to histopathology and to assess the probable causes of failure in cases of pitfalls in cytodiagnosis. Materials and Methods: During the study period of 5 years, a total of 104 cases of retroperitoneal lesions were aspirated under USG guidance. Seven cases yielded inadequate material, the remaining 97 cases were included in the study group. Results: Out of 97 cases, the kidney was the most common organ aspirated (27 cases; 27.8%). Malignant lesions (68 cases; 70.1%) were much more frequent than benign or non-neoplastic lesions (29 cases; 29.9%). Tuberculosis was the most common non-malignant lesion (14 cases) and renal cell carcinoma was the most frequent malignant lesion encountered (15 cases). In 5 cases (7.9%), the histological diagnosis showed inconsistent results in comparison to cytodiagnosis. Conclusion: USG-guided FNAC is a safe, rapid, relatively cheap and fairly accurate procedure for the assessment of retroperitoneal lesions.

Fine-needle aspiration cytology of chondroid syringoma of fore arm: Report of a rare case

Chondroid syringoma is a rare benign adnexal tumor of sweat glands with microscopic resemblance to the salivary gland pleomorphic adenoma. Cytology is rarely utilized for preoperative assessment of these slow-growing, small, nodular lesions. Definitive cytological diagnosis is also quite difficult, and majority of the aspirates are evaluated as benign adnexal tumors leading to mandatory histopathological examination for pinpoint diagnosis. Here, we report a case of chondroid syringoma of forearm, which was diagnosed by cytology and also confirmed after histopathological examination. Pinpoint cytological diagnosis can help early formulation of necessary management protocol.

Quantitative analysis and comparison of mast cells in breast carcinomas and axillary lymph nodes

Introduction: The incidence of breast cancer is increasing throughout the world and it has become the major health problem. Many risk factors and prognostic factors of breast cancer have been identified. Inflammatory cells in the tumor stroma have gained increasing interest on recent time. Aims and Objectives: The study was undertaken to identify the prognostic impact of presence of stromal mast cells in breast carcinomas. Materials and Methods: It was an institution-based descriptive study with cross-sectional design. Total 44 specimens of postoperative breast tissue and dissected axillary lymph nodes of carcinoma breast were taken as sample. After processing of tissue, the slide was stained with hematoxylin and eosin stain and subsequently with toluidine blue stain. Counting of mast cells was done in toluidine blue stain. Results and Analysis: Among 44 cases, the mean age of patients was 45.32 years and infiltrating ductal carcinoma-no special type was the most common type. According to histological grading, Grade III was most common. The mean mast cell count in breast lump was 5.76/high-power field (HPF). The mean mast cell count in axillary lymph node was 11.20/HPF among 27 cases. It was observed that when the tumor grade increases, the number of must cell decreased per HPF. Conclusion: This study indicated that the number of mast cells in breast cancer was inversely correlated with the grade of this tumor.

Clear cell carcinoma of cervix in a postmenopausal woman: A case report

Clear cell carcinoma of cervix is a very rare neoplasm accounting only 4% of all cervical adenocarcinomas. Intrauterine exposure to diethylstilbestrol (DES) is supposed to be causative factor for clear cell adenocarcinoma in childhood and young-age patients. We are reporting a case of clear cell carcinoma of cervix in a 49-years-old multiparous post-menopausal woman, who had no exposure to DES (in-utero) or synthetic non-steroidal estrogen.