Stefan Oberbörsch
Grünenthal GmbH
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Publication
Featured researches published by Stefan Oberbörsch.
ACS Medicinal Chemistry Letters | 2014
Stefan Schunk; Klaus Linz; Sven Frormann; Claudia Hinze; Stefan Oberbörsch; Bernd Sundermann; Saskia Zemolka; Werner Englberger; Tieno Germann; Thomas Christoph; Babette-Y. Kögel; Wolfgang Schröder; Stephanie Harlfinger; Derek Saunders; Achim Kless; Hans Schick; Helmut Dr. Sonnenschein
We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethylamino)-4-phenylcyclo-hexanone 1 and tryptophol in an oxa-Pictet-Spengler reaction led to the formation of spiroether 2, representing a novel NOP and opioid peptide receptor agonistic chemotype. This finding initially stems from the systematic derivatization of 1, which resulted in alcohols 3-5, ethers 6 and 7, amines 8-10, 22-24, and 26-28, amides 11 and 25, and urea 12, many with low nanomolar binding affinities at the NOP and mu opioid peptide (MOP) receptors.
Archive | 2003
Claudia Hinze; Otto Aulenbacher; Bernd Sundermann; Stefan Oberbörsch; Elmar Friderichs; Werner Englberger; Babette-Yvonne Kögel; Klaus Linz; Hans Schick; Helmut Dr. Sonnenschein; Birgitta Henkel; Valerie Sarah Rose; Michael Jonathan Lipkin
Archive | 2004
Claudia Hinze; Bernd Sundermann; Hans Schick; Birgitta Henkel; Werner Englberger; Stefan Oberbörsch; Elmar Friderichs; Sven Frormann; Babette-Yvonne Kögel; Klaus Linz; Beatrix Merla; Derek Saunders; Wolfgang Schröder; Helmut Dr. Sonnenschein
Archive | 2009
Stefan Oberbörsch; Melanie Reich; Bernd Sundermann; Werner Englberger; Sabine Hees; Ruth Jostock; Stefan Schunk; Edward Bijsterveld; Fritz Theil
ACS Medicinal Chemistry Letters | 2014
Stefan Schunk; Klaus Linz; Claudia Hinze; Sven Frormann; Stefan Oberbörsch; Bernd Sundermann; Saskia Zemolka; Werner Englberger; Tieno Germann; Thomas Christoph; Babette-Y. Kögel; Wolfgang Schröder; Stephanie Harlfinger; Derek Saunders; Achim Kless; Hans Schick; Helmut Dr. Sonnenschein
Archive | 2007
Stefan Oberbörsch; Edward Bijsterveld; Thomas Christoph; Michael Engels; Tieno Germann; Sabine Hees; Ruth Jostock; Achim Kless; Melanie Reich; Klaus Schiene; Stefan Schunk
Archive | 2007
Beatrix Merla; Thomas Christoph; Stefan Oberbörsch; Klaus Schiene; Gregor Bahrenberg; Robert Frank; Sven Kühnert; Wolfgang Schröder
Archive | 2005
Stefan Oberbörsch; Bernd Sundermann; Corinna Sundermann; Michael Haurand; Hagen-Heinrich Hennies; Edward Bijsterveld
Archive | 2007
Beatrix Merla; Stefan Oberbörsch; Bernd Sundermann; Werner Englberger; Hagen-Heinrich Hennies; Babette-Yvonne Kögel; Stephan Schunk; Heinz Graubaum
Archive | 2005
Sven Kühnert; Stefan Oberbörsch; Michael Haurand; Ruth Jostock; Klaus Schiene
